2021 Fiscal Year Final Research Report
Search for biomarkers predicting dementia using urine lipidomics analysis
| Project/Area Number |
19K21581
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Studies on the Super-Aging Society
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
渡邊 裕美 新潟大学, 医歯学系, 准教授 (50325479)
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| Project Period (FY) |
2019-06-28 – 2022-03-31
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| Keywords | リピドミクス / 尿 / アルツハイマー病 / バイオマーカー / 予防 |
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| Outline of Final Research Achievements |
In this study, we performed a comprehensive analysis of urinary lipid molecular species using spot urine samples from 18 patients with Alzheimer's disease and age- and sex-matched 18 elderly people with normal cognitive function. Combining the results of a comprehensive analysis of water-soluble metabolites in the same urine samples obtained in previous studies, we examined changes in urinary metabolites specific to patients with Alzheimer's disease. The results suggested a decrease in glycerol 3-phosphate molecules and several molecular species related to lipid metabolism downstream of glycerol 3-phosphate molecules, as well as a decrease in caffeine and its metabolites. This study suggests that urinary metabolites may be a potential biomarker for Alzheimer's disease.
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| Free Research Field |
予防医学
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| Academic Significance and Societal Importance of the Research Achievements |
超高齢社会において認知症はありふれた疾患である。アルツハイマー病は認知症の過半を占め、増加している。本研究では侵襲なく採取できる尿を用いたメタボロミクスにおいてアルツハイマー病患者尿と認知機能正常高齢者尿のメタボロームが異なっていることを示した。本研究で見出されたアルツハイマー病患者尿におけるglycerol-3-phosphateの減少とその関連代謝物の減少は、新たなアルツハイマー病のバイオマーカーの可能性を示唆する。
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