2020 Fiscal Year Final Research Report
Elucidation of the neural basis of mother-pup detachment and effect of the detachment style on social development
| Project/Area Number |
19K21822
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 10:Psychology and related fields
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| Research Institution | Azabu University |
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Principal Investigator |
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| Project Period (FY) |
2019-06-28 – 2021-03-31
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| Keywords | デタッチメント / 視床室傍核 / 前頭前皮質 / オキシトシン |
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| Outline of Final Research Achievements |
The purpose of this study was to clarify the neural mechanisms of detachment, the separation between mother and child during weaning, and the effects of detachment style on development of social behavior. The balance between inhibitory regulation in the paraventricular thalamus from the oxytocin nervous system, which promotes nurturing behavior, and facilitative input from the prefrontal cortex, which regulates behavior from external environments such as stress, was found to be one of the mechanisms controlling detachment. The relationship between detachment style and social development was left as an issue for the future.
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| Free Research Field |
動物行動神経科学
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| Academic Significance and Societal Importance of the Research Achievements |
母と子の結びつきである愛着「アタッチメント」の神経メカニズムや、アタッチメントスタイルの違いが子の社会性発達に及ぼす影響に関しては、これまでも多くの研究がある。本研究から、離乳時期に母と子が離れる「デタッチメント」の神経メカニズムの一端が初めて明らかとなった。今後本研究で確立した母マウスのデタッチメント行動の人為的操作法を用い、離乳時期に母から無視されて親離れする場合や、逆に母が子に過干渉な場合での子マウスの社会性発達を解析できれば、デタッチメントスタイルに起因すると考えられる子の社会性発達に関わる諸問題解決の糸口となることが期待される。
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