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2022 Fiscal Year Final Research Report

Etiologic mechanism of malformation and morphological anomaly focused on collective cell behavior in development

Research Project

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Project/Area Number 19K22433
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 44:Biology at cellular to organismal levels, and related fields
Research InstitutionNara Institute of Science and Technology

Principal Investigator

Bessho Yasumasa  奈良先端科学技術大学院大学, 先端科学技術研究科, 教授 (70261253)

Project Period (FY) 2019-06-28 – 2023-03-31
Keywords奇形 / 形態異常 / 脊椎骨 / 体節 / 遺伝子発現
Outline of Final Research Achievements

Malformation of animals occurs stochastically when genetic and environmental factors perturb the developmental process. In this research, we focused on malformations in the axial skeleton of vertebrates and aimed to reveal the mechanisms of malformation and the robust mechanism to prevent it. Valproic acid, an antiepileptic drug, induces malformation in somites and their derivative, axial skeleton, in mice. We have identified the point of action of valproic acid in somitogenesis. Using Nrarp knockout mice, we also clarified the Nrarp contributions to a robust mechanism in the formation of somites and axial skeletons.

Free Research Field

発生生物学

Academic Significance and Societal Importance of the Research Achievements

これまで、生物の発生プロセスは、遺伝学的解析などでかなりの部分が分子のレベルで明らかにされてきた。しかし、概ね正常であるが一部分だけに形態異常が起こる “奇形”については、アプローチがむずかしいためにメカニズムの解明が遅れていた。本研究は、発生プロセスにバルプロ酸で摂動を与えると奇形が生じる系を利用し、奇形が頻発する遺伝子改変マウス組み合わせて、摂動の作用点を明らかにし、さらにロバスト性メカニズムにアプローチすることで、奇形のメカニズムに切り込むものである。

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Published: 2024-01-30  

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