2020 Fiscal Year Final Research Report

Development of quantitative multinuclear MRI for the elucidation of neurodegenerative diseases

Research Project

Project/Area Number	19K22605
Research Category	Grant-in-Aid for Challenging Research (Exploratory)
Allocation Type	Multi-year Fund
Review Section	Medium-sized Section 52:General internal medicine and related fields
Research Institution	National Institute of Advanced Industrial Science and Technology (2020) Okinawa Institute of Science and Technology Graduate University (2019)
Principal Investigator	HIKISHIMA KEIGO 国立研究開発法人産業技術総合研究所, 生命工学領域, 主任研究員 (30420219)
Project Period (FY)	2019-06-28 – 2021-03-31
Keywords	非侵襲イメージング
Outline of Final Research Achievements	If MRI, a non-invasive imaging tool, can be used to specifically visualize nerve axons and myelin sheaths, as in histopathological analysis, it will be an invaluable tool for understanding the mechanism of various neurological diseases. The aim of this study was to develop a quantitative method of MRI for the diagnosis of neurodegenerative diseases. We have developed a quantitative neural tissue MRI method for mouse spinal cord specimens.
Free Research Field	非侵襲イメージング
Academic Significance and Societal Importance of the Research Achievements	本研究で開発した定量的MRIによって、神経組織構造を病理組織解析のように特異的に捉えることが可能となり、今後、その臨床応用によって様々な神経変性疾患の病態解明に有用な検査技術としての展開が期待される。