2021 Fiscal Year Final Research Report
Development of a new cell based therapy for Hirschsprung's disease
| Project/Area Number |
19K22669
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
吉崎 尚良 金沢医科大学, 医学部, 講師 (00443490)
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| Project Period (FY) |
2019-06-28 – 2022-03-31
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| Keywords | 腸管神経系 / ヒルシュスプルング病 |
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| Outline of Final Research Achievements |
Hirschsprung’s disease is a common disorder of the enteric nervous system, which is present from birth and has an incidence of 1/5,000 live births. Surgical removal of the affected segment has some success, but the long-term outcomes are sporadically poor, especially in cases of the long or extensive type. Cell-based therapy is a potential treatment option for neurointestinal diseases by serving as a source of neural progenitor cells to replace missing or abnormal enteric neurons. In this study, using an in vivo transplantation model, we demonstrated that treatment with collagenase and fibronectin promotes infiltration of transplanted enteric neural crest cells toward the colon lumen.
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| Free Research Field |
小児外科学
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| Academic Significance and Societal Importance of the Research Achievements |
ヒルシュスプルング病の治療法は外科的処置が行われるが、25％の患者で便失禁の合併症があり、患者が多感な小児であることから術後のQOLが問題となっている(Gosemann JH. et al. Eur J Pediatr Surg 2013)。HSCRを発症したすべての児童が健康で文化的な生活を送れるようにするため、外科的処置以外の再生医療や薬剤治療法の開発が望まれている。我々の研究成果は、無神経節結腸の状態を改善する細胞治療の可能性を引き上げることにつながる。
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