Crosstalk between oral and systemic responses

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K22702
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 57:Oral science and related fields
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Azuma Miyuki 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (90255654)
• Co-Investigator(Kenkyū-buntansha): 平山 和宏 東京大学, 大学院農学生命科学研究科(農学部), 教授 (60208858) ; 竹内 康雄 東京医科歯科大学, 大学院医歯学総合研究科, 講師 (60396968)
• Project Period (FY): 2019-06-28 – 2022-03-31
• Keywords: 腸内細菌 / 歯周細菌 / 腸管免疫 / 口腔免疫

Outline of Final Research Achievements

We found the dysbiosis occured in periodontal plaques between healthy donors and patients with severe periondontitis by microbiome analyses. We successfully performed anaerobic 10 Frequently-detectable severe periodontitis bacteria (FSPB) culture. Development of dextran sulfate sodium-induced colitis, which mimic human ulcerative colitis, were differ in three mouse breeder companies. This differences were related to intestinal microbiome and immune responses. We will plan to analyze the effects of 10FSPB treatment by oral feeding or gingival application.

Free Research Field

免疫学、口腔科学（歯学）

Academic Significance and Societal Importance of the Research Achievements

残念ながら、最終結果の獲得には至らなかったが、樹立したマウス実験モデルで、歯周病細菌と全身疾患との関連を模倣することができれば、今後の口腔と全身とのクローストーク解析に新規のアプローチを生み出すことになる。