2022 Fiscal Year Final Research Report
Analysis of factors associated with global spread of enterovirus D68
| Project/Area Number |
19K22733
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 58:Society medicine, nursing, and related fields
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2019-06-28 – 2023-03-31
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| Keywords | エンテロウイルスD68 / EVD68 / フィリピン / 呼吸器感染症 |
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| Outline of Final Research Achievements |
Enterovirus D68（EV-D68）caused a significant global outbreak from 2014-2015. However, the exact mechanism for such a global outbreak was unknown. We analyzed EV-D68 detected in the Philippines, including molecular analysis, antigenic analysis, and clinical severity. We found that the outbreak in 2015 was caused by clade switch from clade D to clade B. Also, some antigenic difference between clade B and clade D was observed. However, there was no difference in clinical severity between these two clades. These results suggest that the outbreak in 2015 was mainly caused by the emergence of antigenically different clade, clade B.
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| Free Research Field |
ウイルス学、感染症疫学
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| Academic Significance and Societal Importance of the Research Achievements |
エンテロウイルスD68（EV-D68）は2014年～2015年に世界的流行を起こしたウイルスで、その際には呼吸器感染症の重症例だけではなく急性弛緩性麻痺例も世界各地で数多く報告された。なぜそのようなことが起きたかというメカニズムを解明することは、今後の新興感染症の流行の予知や予防にとって重要なものである。COVID-19の原因ウイルスであるSARS-CoV-2も変異を繰り返すことで流行が継続しているが、EV-D68も同じようなメカニズムで流行が起きている可能性を示せたことは、重要な意義があると考えられる。
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