鼻茸をはじめとする慢性副鼻腔炎の危険因子としての環境中化学物質に関する疫学研究

2021 Fiscal Year Annual Research Report

• Project/Area Number: 19K22751
• Research Institution: Kanazawa University
• Principal Investigator: 中村 裕之 金沢大学, 医学系, 教授 (30231476)
• Co-Investigator(Kenkyū-buntansha): 辻口 博聖 金沢大学, 医学系, 特任助教 (00723090) ; 神林 康弘 岡山理科大学, 獣医学部, 教授 (20345630) ; 早川 和一 金沢大学, その他部局等, 名誉教授 (40115267) ; 吉崎 智一 金沢大学, 医学系, 教授 (70262582) ; 原 章規 金沢大学, 医学系, 准教授 (70507045)
• Project Period (FY): 2019-06-28 – 2022-03-31
• Keywords: 鼻茸 / 環境中化学物質 / 多環芳香族炭化水素 / 気管支喘息 / 疫学

Outline of Annual Research Achievements

鼻茸をはじめとする慢性副鼻腔炎は難治性であり、近年、急速に増加しており、喫緊の大きな医学的な問題である。鼻茸は遺伝性ではなく、遅い思春期以降の遅い時期に発症し、環境因子、特に環境中化学物質の関与を強く疑われているが、詳細はほとんど知られていない。本研究では、鼻茸においても成人型の気管支喘息症と同様に、大気中の化学物質との因果関係を示す疫学を実施し、鼻茸をはじめとする慢性副鼻腔炎の危険因子を大気中化学物質、特に多環芳香族炭化水素（Polycyclic Aromatic Hydrocarbon, PAH）や重金属を中心に疫学的に調べ、新しい予防法を提示する。
金沢市および石川県志賀町における拠点病院・医院の鼻茸患者、鼻茸を有しない副鼻腔炎患者12人を含む咳喘息、アトピー性咳嗽あるいは気管支喘息患者55人をリクルートし、鼻症状、喉症状や咳を引き続き、モニタリングした。この間、PAH類10種類、NPAH類10種類、OHPAH類16種類、QPAH類32種類を測定した。Total suspended particleや重金属を含めた一般化推定方程式によって評価した結果、PAHの中で、ベンズ[a]アントラセン（BaA）およびピレン（Pyr）が有意なあるいはその傾向を示す正の相関を認めた。NPAH類、OHPAH類、QPAH類の動向からも、地域の交通車両由来のPAH類の関与が示唆される結果であった。このように鼻茸の症状の悪化には、ある一定のPAH類の関与が考えられ、鼻茸をはじめとする慢性副鼻腔炎の予防には、大気汚染物質の管理が重要であることが提言された。

Research Products

• [Journal Article] Relationship between Alcohol Intake and Chronic Pain with Depressive Symptoms: A Cross-Sectional Analysis of the Shika Study (2022)
  • Author(s): Takashi Amatsu,Hiromasa Tsujiguchi,Akinori Hara,Sakae Miyagi,Takayuki Kannon,Keita Suzuki,Yukari Shimizu,Thao Thi Thu Nguyen,Kim-Oanh Pham,Fumihiko Suzuki,Tomoko Kasahara,Masaharu Nakamura,Koichiro Hayashi,Aki Shibata,Noriyoshi Ogino,Tadashi Konoshita,Yasuhiro Kambayashi,Hirohito Tsuboi,Atsushi Tajima,Hiroyuki Nakamura
  • Journal Title: Int J Environ Res Public Health. Volume: 19(4) Pages: 2024
  • DOI: 10.3390/ijerph19042024.
  • Peer Reviewed / Open Access
• [Journal Article] A retrospective cohort study on the association between poor sleep quality in junior high school students and high hemoglobin A1c level in early adults with higher body mass index values. (2022)
  • Author(s): Kasahara T, Tsujiguchi H, Takeshita Y, Hara A, Suzuki K, Narukawa N, Hayashi K, Miyagi M, Asai A, Yamada Y, Nakamura H, Suzuki F, Pham KO, Hamagishi T, Nakamura M, Shibata A, Shimizu Y, Nguyen TTT, Miyagi S, Kambayashi Y, Kannon T, Tajima A, Tsuboi H, Konoshita T, Takamura T, Nakamura H.
  • Journal Title: BMC Endocr Disord. Volume: 22(1) Pages: 40
  • DOI: 10.1186/s12902-022-00951-6.
  • Peer Reviewed / Open Access
• [Journal Article] Ginger facilitates cell migration and heat tolerance in mouse fibroblast cells. (2021)
  • Author(s): Naotoshi Sugimoto, Masanori Katakura, Kentaro Matsuzaki, Mayumi Miyamoto, Eri Sumiyoshi, Taizo Wada, Akihiro Yachie, Hiroyuki Nakamura, Osamu Shido
  • Journal Title: Mol Med Rep Volume: 23(4) Pages: 250
  • DOI: 10.3892/mmr.2021.11889.
  • Peer Reviewed / Open Access
• [Journal Article] The association between overweight and prevalence of food allergy in Japanese children: a cross-sectional study. (2021)
  • Author(s): Koichiro Hayashi, Hiromasa Tsujiguchi, Daisuke Hori, Yohei Yamada, Yukari Shimizu, Thao Thi Thu Nguyen, Yuri Hibino, Yasuhiro Kambayashi, Akinori Hara, Hiroyuki Nakamura
  • Journal Title: Environ Health Prev Med. Volume: 26(1) Pages: 44
  • DOI: 10.1186/s12199-021-00960-2.
  • Peer Reviewed / Open Access
• [Journal Article] Moderate alcohol consumption is associated with impaired insulin secretion and fasting glucose in non-obese non-diabetic men. (2021)
  • Author(s): Miyagi S, Takamura T, Nguyen TTT, Tsujiguchi H, Hara A, Nakamura H, Suzuki K, Tajima A, Kannon T, Toyama T, Kambayashi Y, Nakamura H
  • Journal Title: J Diabetes Investig. Volume: 12(5) Pages: 869-876
  • DOI: 10.1111/jdi.13402.
  • Peer Reviewed / Open Access
• [Journal Article] Validation of the Japanese Version of the Center for Epidemiologic Studies Depression Scale-Revised: A Preliminary Analysis (2021)
  • Author(s): Hirohito Tsuboi, Yui Takakura, Hiromasa Tsujiguchi, Sakae Miyagi, Keita Suzuki, Thao Thi Thu Nguyen, Kim Oanh Pham, Yukari Shimizu, Yasuhiro Kambayashi, Naoko Yoshida, Akinori Hara, Hiroyuki Nakamura
  • Journal Title: Behavioral Sciences. Volume: 11(8) Pages: 107-107
  • DOI: 10.3390/bs11080107.
  • Peer Reviewed / Open Access
• [Journal Article] Relationships among the β3-adrenargic receptor gene Trp64Arg polymorphism, hypertension, and insulin resistance in a Japanese population. (2021)
  • Author(s): Youhei Yamada, Haruki Nakamura, Hiromasa Tsujiguchi, Akinori Hara, Sakae Miyagi, Takayuki Kannon, Takehiro Sato, Kazuyoshi Hosomichi, Thao Thi Thu Nguyen, Yasuhiro Kambayashi, Yukari Shimizu, Kim Oanh Pham, Keita Suzuki, Fumihiko Suzuki, Tomoko Kasahara, Hirohito Tsuboi, Atsushi Tajima, Hiroyuki Nakamura.
  • Journal Title: PLOS ONE. Volume: 16(8) Pages: e0255444
  • DOI: 10.1371/journal.pone.0255444.
  • Peer Reviewed / Open Access
• [Journal Article] Particulate PAH Transport Associated with Adult Chronic Cough Occurrence Closely Connected with Meteorological Conditions: A Modelling Study. (2021)
  • Author(s): Yayoi Inomata, Masato Takeda, Nguyen Thao, Mizuo Kajino, Takafumi Seto, Hiroyuki Nakamura, Kazuichi Hayakawa
  • Journal Title: Atmosphere. Volume: 12(9) Pages: 1163
  • DOI: 10.3390/atmos12091163,2021.
  • Peer Reviewed / Open Access
• [Journal Article] Effect of β3-adrenergic receptor gene polymorphism and lifestyle on overweight Japanese rural residents: A cross-sectional study. (2021)
  • Author(s): Hara A, Nguyen PM, Tsujiguchi H, Nakamura M, Yamada Y, Suzuki K, Suzuki F, Kasahara T, Pham OK, Nakamura H, Kambayashi Y, Shimizu Y, Nguyen TTT, Miyagi S, Kannon T, Sato T, Hosomichi K, Tajima A, Nakamura H.
  • Journal Title: Obes Sci Pract. Volume: 8(2) Pages: 199-207
  • DOI: 10.1002/osp4.560.
  • Peer Reviewed / Open Access
• [Journal Article] Increased Prevalence of Atopic Dermatitis in Children Aged 0-3 Years Highly Exposed to Parabens. (2021)
  • Author(s): Arafune J, Tsujiguchi H, Hara A, Shimizu Y, Hori, D, Thao Thi Thu Nguyen,Suzuki F, Hamagishi T, Yamada Y, Nakamura H,Yoshikawa T, Hayashi K, Shibata A, Fukutomi Y, Ohya Y, Yamamoto-Hanada K, Muto G, Hirota R, Konoshita T, Kambayashi Y, Nakamura Hiroyuki.
  • Journal Title: Int J Environ Res Public Health. Volume: 18(21) Pages: 11657
  • DOI: 10.3390/ijerph182111657.
  • Peer Reviewed / Open Access
• [Journal Article] Polygenic risk scores for low-density lipoprotein cholesterol and familial hypercholesterolemia. (2021)
  • Author(s): Akihiro Nomura, Takehiro Sato, Hayato Tada, Takayuki Kannon, Kazuyoshi Hosomichi, Hiromasa Tsujiguchi, Hiroyuki Nakamura, Masayuki Takamura, Atsushi Tajima, Masa-Aki Kawashir.
  • Journal Title: Journal of human genetics. Volume: 66(11) Pages: 1079-1087
  • DOI: 10.1038/s10038-021-00929-7.
  • Peer Reviewed / Open Access
• [Journal Article] Alcohol Intake Is Associated With Elevated Serum Levels of Selenium and Selenoprotein P in Humans. (2021)
  • Author(s): Isobe Y, Asakura H, Tsujiguchi H, Kannon T, Takayama H, Takeshita Y, Ishii KA, Kanamori T, Hara A, Yamashita T, Tajima A, Kaneko S, Nakamura H, Takamura T.
  • Journal Title: Front Nutr. Volume: 8 Pages: 696947
  • DOI: 10.3389/fnut.2021.696947.
  • Peer Reviewed / Open Access
• [Presentation] 福岡における大気汚染物質と小児呼吸器患者における症状の関連に関する研究 (2021)
  • Author(s): 小田嶋博, 松崎寛司, 村上洋子, 赤峰裕子, 吉野彩子, 高見昭憲, 早川和一, 原章規, 中村裕之
  • Organizer: 第70回日本アレルギー学会学術大会
• [Presentation] 非２型喘息の増悪予測因子－Tenascin-CとIL-6の有用性－ (2021)
  • Author(s): 長瀬洋之, 岩永賢司, 田中明彦, 増子裕典, 斎藤純平, 鈴川真穂, 町田健太朗, 原田紀宏, 相良博典, 檜澤伸之, 井上博雅, 谷口正実, 中村裕之, 東田有智, 大田健
  • Organizer: 第70回日本アレルギー学会学術大会