2021 Fiscal Year Final Research Report

Epidemiological studies on environmental chemicals as risk factors for chronic sinusitis, including nasal polyps

Research Project

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Project/Area Number	19K22751
Research Category	Grant-in-Aid for Challenging Research (Exploratory)
Allocation Type	Multi-year Fund
Review Section	Medium-sized Section 58:Society medicine, nursing, and related fields
Research Institution	Kanazawa University
Principal Investigator	NAKAMURA Hiroyuki 金沢大学, 医学系, 教授 (30231476)
Co-Investigator(Kenkyū-buntansha)	辻口博聖金沢大学, 医学系, 特任助教 (00723090) 神林康弘岡山理科大学, 獣医学部, 教授 (20345630) 早川和一金沢大学, その他部局等, 名誉教授 (40115267) 吉崎智一金沢大学, 医学系, 教授 (70262582) 原章規金沢大学, 医学系, 准教授 (70507045)
Project Period (FY)	2019-06-28 – 2022-03-31
Keywords	鼻茸 / 環境中化学物質 / 多環芳香族炭化水素 / 気管支喘息 / 疫学
Outline of Final Research Achievements	Since chronic sinusitis such as nasal polyps is intractable and has been increasing rapidly in recent years, its prevention is an urgent medical problem. In order to elucidate the cause of nasal polyps, in this study, we recruited 55 patients with cough, atopic cough or bronchial asthma, including 12 patients with nasal polyps and sinusitis. The generalized estimation equation analyzing the relationship with nasal symptoms showed total polycyclic aromatic hydrocarbon, benz [a] anthracene and pyrene were significantly (or appropriately significantly) positively correlated with nasal symptoms. This relationship was similar after adjustment for the covariates of gender, age, presence or absence of asthma, BMI, SO2, NO2, and PM2.5. In this way, certain PAHs derived from local traffic vehicles are considered to be involved in the worsening of nasal polyps. Our results suggest that the control of air pollutants is important for the prevention of chronic sinusitis such as nasal polyps.
Free Research Field	公衆衛生学
Academic Significance and Societal Importance of the Research Achievements	鼻茸をはじめとする慢性副鼻腔炎は難治性であり、近年、急速に増加しており、その予防は、喫緊の大きな医学的な問題である。本研究では、鼻茸の成因を解明するために環境中化学物質と鼻症状との関係を解析した結果、鼻茸の症状の悪化には、地域の交通車両由来のある一定の多環芳香族炭化水素の関与が考えられた。したがって鼻茸をはじめとする慢性副鼻腔炎の予防には、環境政策上、多環芳香族炭化水素を中心とする大気汚染物質の管理が重要であると提言できる。