Identification of blood biomarkers reflecting qualitative changes in skeletal muscle

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K22828
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
• Research Institution: Ritsumeikan University
• Principal Investigator: Iemitsu Motoyuki 立命館大学, スポーツ健康科学部, 教授 (90375460)
• Co-Investigator(Kenkyū-buntansha): 長谷川 夏輝 立命館大学, 総合科学技術研究機構, 研究員 (00822850) ; 真田 樹義 立命館大学, スポーツ健康科学部, 教授 (50421227) ; 橋本 健志 立命館大学, スポーツ健康科学部, 教授 (70511608)
• Project Period (FY): 2019-06-28 – 2022-03-31
• Keywords: マイオカイン / 加齢 / 運動 / 筋質

Outline of Final Research Achievements

The purpose of this study examined novel blood biomarker that reflect skeletal muscle quality (increases in adipocytes and fibroblasts and decrease in muscle fiber). We examined the association between the effects of serumC1q level and muscle quality on 12wk resistance training intervention (70% 1RM, 10 times x 3 sets, 3 days/week) in healthy older women. 12-wk resistance training in older women improved femoral muscle echo intensity, as an indicator of muscle quality, and reduced serum C1q levels. The training effect of serum C1q level significantly correlated with the change in the muscle quality. The blood level of C1q may be a biomarker for muscle quality.

Free Research Field

健康科学

Academic Significance and Societal Importance of the Research Achievements

本研究成果は，C1qがヒトの骨格筋の質的な変化が評価が可能な血液バイオマーカーとして有効である可能性を示しており，これまでヒトの筋質（筋の脂肪化・線維化の増加および筋線維の低下）の評価が容易でなかったが，血液バイオマーカーを用いて評価することが可能となる発展性の高い研究課題である。