Development of all-in-one nanomedicine for sonoimmunotherapy

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K22977
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 90:Biomedical engineering and related fields
• Research Institution: Osaka Prefecture University
• Principal Investigator: Harada Atsushi 大阪府立大学, 工学(系)研究科(研究院), 教授 (50302774)
• Project Period (FY): 2019-06-28 – 2022-03-31
• Keywords: 超音波免疫治療 / 酸化チタンナノ粒子 / サイトカイン産生 / 樹状細胞活性化

Outline of Final Research Achievements

In this study, we proposed a new concept of immunotherapy called ultrasonic immunotherapy, which activates the immune system by inducing cell death of cancer cells by ultrasonic irradiation, and created an all-in-one nanomedicine with the purpose of creating the necessary functions. By complexing TiO2 nanoparticles that generate active oxygen species by ultrasonic irradiation with synthetic polymer materials, the ability to activate immune cells, activate immune cells, and deliver cancer antigens to immune cells by ultrasonic irradiation can be achieved. It was confirmed through cultured cell experiments and animal experiments that the all-in-one nanomedicine created in one carrier could be prepared.

Free Research Field

生体機能材料学

Academic Significance and Societal Importance of the Research Achievements

三大がん治療方法（外科治療、化学治療、放射線治療）に加えて、第四のがん治療方法としてがん免疫治療が注目されている。この治療方法は副作用が少なく，侵襲性の低い治療法であることから，高齢化社会において患者のQOLを高める治療法として期待されている。低侵襲性を維持しつつ、治療効果を高めるために超音波を利用するシステムに開発に取り組み、新規な治療方法の開発につながる知見を得た。