Analysis of a factor that restricts viral propagation in plant antiviral immunity

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K23660
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0601:Agricultural chemistry and related fields
• Research Institution: National Agriculture and Food Research Organization (2020); The University of Tokyo (2019)
• Principal Investigator: Tetsuya Yoshida 国立研究開発法人農業・食品産業技術総合研究機構, 生物機能利用研究部門, 研究員 (00809874)
• Project Period (FY): 2019-08-30 – 2021-03-31
• Keywords: 植物ウイルス / 抵抗性

Outline of Final Research Achievements

Understanding the mechanism of plant antiviral immunity is important for disease-resistance breeding. I investigated whether various mutants of the noncanonical antiviral resistance factor JAX1 could inhibit viral replication, and identified some regions and amino acid residues that are crucial for the function of JAX1. I also revealed that a specific sequence enhances the spread of a plant virus in its host.

Free Research Field

植物病理学

Academic Significance and Societal Importance of the Research Achievements

JAX1による抵抗性の発現に重要な領域およびアミノ酸残基を同定できたことから、本研究は特異な因子をコードし未解明の部分の多い抵抗性遺伝子JAX1の分子機能の全容解明に向けた基盤的知見となると考えられる。また、植物ウイルスの感染域を拡大する活性を有する配列を見出したことから、本研究はウイルスの全身感染様式の詳細な理解に資すると考えられる。