Elucidation of Microbiome which is related to pancreatic carcinogenesis, metastasis using NGS and application to the treatment

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K23918
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0901:Oncology and related fields
• Research Institution: Kyushu University
• Principal Investigator: ABE Toshiya 九州大学, 医学研究院, 共同研究員 (20722028)
• Project Period (FY): 2019-08-30 – 2021-03-31
• Keywords: 膵癌 / Microbiome / オルガノイド / 化学療法耐性

Outline of Final Research Achievements

Our purpose is to identify of microbiome about pancreatic carcinogenesis and metastasis using NGS and to develop of pancreatic cancer treatment targeting specific microbiome.
At first, we verified the existence of intratumor bacteria by immunohistochemistry using the anti-LPS antibody in the pancreatic cancer samples of human and mice. Next, to identify the change of gut microbiome, we performed meta genome analysis by NGS. In the orthotopic spontaneous pancreatic carcinogenesis model, we found the decrease of Akkermansia in gut microbiome. Akkermansia is known as probiotics, and is regarded as a candidate of pancreatic cancer restraint microbiome.

Free Research Field

医歯薬学

Academic Significance and Societal Importance of the Research Achievements

膵癌が誘導する腸内細菌叢の変化が膵癌の進展に関わることや、膵癌により腸内細菌叢が変化するメカニズムを解明することができれば、ヒトの腸内細菌叢の解析により膵癌早期発見のスクリーニングや特定のMicrobiomeを標的とした新規治療法の開発に繋がると考えられる。