Prospective cohort study for intracranial aneurysm in the Hisayama elderly population based on brain MRI

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K23971
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0902:General internal medicine and related fields
• Research Institution: Kyushu University
• Principal Investigator: Furuta Yoshihiko 九州大学, 医学研究院, 助教 (60850005)
• Project Period (FY): 2019-08-30 – 2021-03-31
• Keywords: 疫学研究 / コホート研究 / 脳動脈瘤 / 脳卒中 / MRI / 地域一般住民 / 高齢者

Outline of Final Research Achievements

The prevalence of intracranial cerebral aneurysms was evaluated in 1,286 Hisayama residents aged 65 and over who underwent head MRI examination in 2012. As a result, a total of 54 cerebral aneurysms were found in 52 subjects, and the prevalence of cerebral aneurysms was 4.0%. The logistic regression analysis showed that women and smoking habits were significant risk factors for cerebral aneurysms.
Then, we examined the cumulative incidence of cerebral aneurysms in 866 people who did not have cerebral aneurysms in 2012 and underwent follow-up MRI examinations in 2017. The development of new cerebral aneurysms was observed in 8 subjects in MRI in 2017, and the cumulative incidence rate at 5 years was 0.92%. Due to the small number of cases with new cerebral aneurysms, it was difficult to investigate risk factors for the development of cerebral aneurysms.

Free Research Field

脳卒中の疫学

Academic Significance and Societal Importance of the Research Achievements

本研究の結果から、地域一般高齢者における脳動脈瘤の有病率およびその後の発症率が示された。また女性と喫煙習慣が脳動脈瘤保有の危険因子であった。これらの情報はわが国の高齢者における脳動脈瘤・くも膜下出血の病態解明やその予防対策の確立に寄与し、ひいては国民の保健・医療・福祉の向上につながることが期待される。今後、本研究の成果を海外学術誌に報告予定である。