Analysis of immune microenvironment of NF2-related tumor

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K24023
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0906:Surgery related to the biological and sensory functions and related fields
• Research Institution: The University of Tokyo
• Principal Investigator: Teranishi Yu 東京大学, 医学部附属病院, 助教 (50844635)
• Project Period (FY): 2019-08-30 – 2021-03-31
• Keywords: 神経線維腫症２型 / 髄膜腫 / 神経鞘腫 / 腫瘍免疫

Outline of Final Research Achievements

This study described 1) the correlation between variant allele frequency with NF2 mutation and NF2-related tumor behavior and 2) the evaluation of immune microenvironment of NF2-related meningioma, comparing with those of sporadic NF2 mutated meningiomas. Firstly, we found that the highly diverse phenotype of NF2 could be resulting from the extent of VAF in the NF2 variant within normal tissue DNA. Secondly, we found that NF2-related meningioma had different immune status from those of sporadic NF2 mutated meningiomas.

Free Research Field

脳神経外科

Academic Significance and Societal Importance of the Research Achievements

本研究はNF2関連腫瘍である神経鞘腫と髄膜腫の発生機序が異なる可能性があること、また同じ髄膜腫であってもNF2関連髄膜腫と孤発性NF2変異髄膜腫では異なることを発見した。これは現在有効な根治治療薬が無いNF2においては新たな治療ターゲット探索研究の基盤となる可能性がある。