• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2020 Fiscal Year Final Research Report

Modulation of gingival epithelial barrier function by TRP channel proteins

Research Project

  • PDF
Project/Area Number 19K24139
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeMulti-year Fund
Review Section 0907:Oral science and related fields
Research InstitutionNiigata University

Principal Investigator

Hara Miki  新潟大学, 医歯学総合研究科, 助教 (60848266)

Project Period (FY) 2019-08-30 – 2021-03-31
Keywords上皮バリア / TRPチャネルタンパク / TRPV1
Outline of Final Research Achievements

TRP channel protein is expressed in the gingival epithelium, but there are few reports on its physiological role in periodontal tissues. The purpose of this study was to clarify the regulation of barrier function of gingival epithelial cells via TRP channel protein.
The stimulation of gingival epithelial cells with capsaicin, a TRPV1 agonist, induced the expression of barrier-related genes. However, in the epithelial permeability assay showed capsaicin had no clear tendency to enhance the barrier function. On the other hand, capsaicin significantly reduced the production of TNF-α-induced inflammatory cytokines. These results suggest that TRPV1 is involved in immunological regulation of barrier function.

Free Research Field

歯周病学

Academic Significance and Societal Importance of the Research Achievements

近年同定されたTransient receptor potential(TRP) タンパクファミリーは、温度・機械刺激・化学刺激などによって活性化されるカルシウムイオンチャネルで、様々な疾患との関連性が報告されている。上皮細胞に発現するTRPタンパクが皮膚や血管のバリア機能制御に関与することが知られているが、歯肉上皮のバリア機能におけるそれらの関与については報告がほとんどない。TRPチャネルタンパクの関与とその分子メカニズムを明らかにすることで、宿主のバリア機能強化という視点から、新しい歯周病予防・治療法の確立を目指すことは社会的意義が大きい。

URL: 

Published: 2022-01-27  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi