Evaluation of the relationship between local circulation disorder and coagulation/fibrinolysys-system induced by hemorrhage in animal model

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K24167
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0908:Society medicine, nursing, and related fields
• Research Institution: Kumamoto University
• Principal Investigator: Furukawa Shota 熊本大学, 大学院生命科学研究部(医), 特任助教 (90849093)
• Project Period (FY): 2019-08-30 – 2021-03-31
• Keywords: 出血 / 組織低酸素 / ミトコンドリア呼吸

Outline of Final Research Achievements

This study aimed to compare different hemorrhage style (arterial hemorrhage or venous hemorrhage) for clarifying their effects on the mitochondrial respiration in organs of rat.
Male Sprague-Dawley rats (300-339 g) were randomly assigned to three groups: control, arterial bleeding, and venous bleeding. Hemorrhage was induced by withdrawing blood until 50% (28 ml/kg) of their estimated blood volume (56 ml/kg) in both bleeding groups. Blood pressure in both bleeding groups was decreased compared with the control group. Blood pressure showed no significant difference between the arterial and venous bleeding groups. Preliminary respiratory capacity of mitochondria in heart in the arterial bleeding group was lower compared with the control group.

Free Research Field

法医学

Academic Significance and Societal Importance of the Research Achievements

本研究課題は出血による各臓器のミトコンドリア機能への影響の解明に繋がる可能性がある。