Beneficial effects of artificial sweeteners on glucose metabolism and skeletal muscle function

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K24332
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0909:Sports sciences, physical education, health sciences, and related fields
• Research Institution: Fukuoka University
• Principal Investigator: Yamamoto Taiki 福岡大学, スポーツ科学部, 助教 (10845506)
• Project Period (FY): 2019-08-30 – 2022-03-31
• Keywords: 人工甘味料 / 骨格筋 / 耐糖能異常 / アセスルファムK / スクラロース

Outline of Final Research Achievements

Artificial sweeteners that are valuable for especially diabetics and obesity patients be able to feel sweetness while reducing calorie intake. So many foods use a variety of low-calorie artificial sweeteners instead of high-calorie sugar. In particular, the effects of artificial sweeteners on skeletal muscle, which is deeply involved in glucose metabolism, obesity and/or diabetes , has not been reported. In this study, we reported the effects of artificial sweetener intake on glucose metabolism markers, skeletal muscle mass, and skeletal muscle synthesis markers. It has been reported that long-term artificial sweetener intake may show opposite results depending on the concentration. Administration of high-concentration artificial sweeteners and administration has shown the potential to increase skeletal muscle mass and skeletal muscle synthesis markers.

Free Research Field

運動生理学

Academic Significance and Societal Importance of the Research Achievements

人工甘味料は広く普及しており多くの食品に使用されているものの、その効果の全容は不明な点が多い。また、人工甘味料の種類により吸収経路が異なり、摂取量や期間による影響もあり効果の一貫した回答が得られていない。人工甘味料が骨格筋へ影響を与えることはほとんど知られておらず、本研究では、近年使用頻度が高まっている2つの人工甘味料に着目し、その血糖県連指標並びに骨格筋に対する影響を明らかにした。今後はさらに運動との組み合わせを検証していく必要性がある。