Role of Inflammasomes as an initial sensor for cardiovascular stress

2010 Fiscal Year Final Research Report

• Project/Area Number: 20200077
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
• Allocation Type: Single-year Grants
• Research Field: Circulatory organs internal medicine; Experimental pathology
• Research Institution: Shinshu University
• Principal Investigator: TAKAHASHI Masafumi Shinshu University, 医学部, 教授 (40296108)
• Co-Investigator(Renkei-kenkyūsha): TANIGUCHI Shun'ichiro (60117166) ; IKEDA Uichi (30221063)
• Project Period (FY): 2008 – 2010
• Keywords: インフラマソーム / 心血管 / シグナル伝達

Research Abstract

Inflammation plays a key role in the pathophysiology of cardiovascular diseases. In particular, recent studies suggest that a sterile inflammatory response is mediated through a multiple-protein complex called the inflammasomes. The purpose of this study is to investigate the role of inflammasomes in the pathogenesis of cardiovascular diseases and explore a therapeutic potential of regulating inflammasomes for cardiovascular diseases using a murine model of myocardial ischemia-reperfusion (I/R) injury. Our results demonstrate the importance of inflammasomes for the initial inflammatory response after myocardial I/R and suggest that the inflammasome is a potential novel therapeutic target for preventing myocardial I/R injury.

Research Products

• [Journal Article] Inflammasome activation of cardiac fibroblasts is essential for myocardial ischemia reperfusion injury. (2011)
  • Author(s): Kawaguchi M, Takahashi M, Hata T, Kashima Y, Usui F, Morimoto, Izawa A, Takahashi Y, Masumoto J, Koyama J, Hongo M, Noda T, Nakayama J, Sagara J, Taniguchi S, Ikeda U.
  • Journal Title: Circulation 123 Pages: 594-604
• [Journal Article] Critical role of Th17 cells in inflammation and neovascularization after ischemia. (2011)
  • Author(s): Hata T, Takahashi M, Hida S, Kawaguchi M, Kashima Y, Usui F, Morimoto, Nishiyama A, Izawa A, Koyama J, Iwakura Y, Taki S, Ikeda U.
  • Journal Title: Cardiovasc Res 90 Pages: 364-372
• [Journal Article] Role of the SDF-1/CXCR4 system in myocardial infarction. (2010)
  • Author(s): Takahashi M.
  • Journal Title: Circ J 74 Pages: 418-423
• [Journal Article] Immature erythroid cells : a new source for therapeutic angiogenesis (2010)
  • Author(s): Takahashi M.
  • Journal Title: J Mol Cell Cardiol 49 Pages: 341-342
• [Journal Article] Therapeutic neovascularization by the implantation of autologous mononuclear cells in patients with connective tissue diseases. (2009)
  • Author(s): Takahashi M, Izawa A, Ishigatsubo Y, Fujimoto K, Miyamoto M, Horie T, Aizawa Y, Amano J, Minota S, Murohara T, Matsubara H, Ikeda U.
  • Journal Title: Curr Pharm Design 15 Pages: 2778-2783
• [Journal Article] Bone marrow CXCR4 induction by cultivation enhances therapeutic angiogenesis. (2009)
  • Author(s): Shiba Y, Takahashi M, Hata T, Murayama H, Morimoto H, Ise H, Nagasawa T, Ikeda U.
  • Journal Title: Cardiovasc Res 81 Pages: 169-177
• [Journal Article] Surface coating of bone marrow cells with N-acetylglucosamine for bone marrow implantation therapy. (2009)
  • Author(s): Kobayashi S, Ise H, Takahashi M, Goto M, Akaike T, Ikeda U.
  • Journal Title: Biomaterials 30 Pages: 574-582
• [Journal Article] Genetic susceptibility to restenosis : Role of bone marrow cells and inflammatory response. (2009)
  • Author(s): Takahashi M.
  • Journal Title: Arterioscler Thromb Vasc Biol 10 Pages: 1407-1408
• [Journal Article] Critical role of bone marrow apoptosis-associated speck-like protein, an inflammasome adaptor molecule, in neointimal formation after vascular injury in mice. (2008)
  • Author(s): Yajima N, Takahashi M, Morimoto H, Shiba Y, Takahashi Y, Masumoto J, Ise H, J Sagara, Nakayama J, Taniguchi S, Ikeda U.
  • Journal Title: Circulation 117 Pages: 3079-3087
• [Journal Article] Deficiency of tumor necrosis factor-alpha and interferon-gamma in bone marrow cells synergistically inhibits neointimal formation following vascular injury. (2008)
  • Author(s): Murayama H, Takahashi M, Takamoto M, Shiba Y, Ise H, Koyama J, Tagawa Y, Iwakura Y, Ikeda U.
  • Journal Title: Cardiovasc Res 80 Pages: 175-180
• [Journal Article] MCP-1 induces cardioprotection against ischemia/reperfusion injury : Role of reactive oxygen species. (2008)
  • Author(s): Morimoto H, Hirose M, Takahashi M, Kawaguchi M, Ise H, Kolattukudy PE, Yamada M, Ikeda U.
  • Journal Title: Cardiovasc Res 78 Pages: 554-562
• [Presentation] Role of inflammasome in cardiovascular diseases. (2010)
  • Author(s): Takahashi M, Taniguchi S.
  • Organizer: 14^<th> International Congress of Immunology
  • Place of Presentation: 神戸
  • Year and Date: 20100822-20100827
• [Presentation] Role of inflammasome in cardiovascular diseases. (2010)
  • Author(s): Takahashi M.
  • Organizer: International Academy of Cardiology, 15^<th> World Congress on Heart Disease
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 20100723-20100727
• [Presentation] Deficiency of ASC (apotosis-associated speck-like protein containing a caspase recruitment domain) in bone marrow cells improved myocardial ischemia-reperfusion injury in mice. (2009)
  • Author(s): Kawaguchi M., Takahashi M, Hata T, Kashima Y, Takahashi Y, Sagara J, Taniguchi S, Ikeda U.
  • Organizer: American Heart Association Scientific Sessions
  • Place of Presentation: Orlando, USA
  • Year and Date: 20091114-20091118
• [Presentation] Contribution of Th17 cells, a new subset of CD4^+ T cells, to angiogenic response to hindlimb ischmia. (2009)
  • Author(s): Hata T, Takahashi M, Kawaguchi M, Kashima Y, Izawa A, Hida S, Iwakuma Y, Taki S, Ikeda U.
  • Organizer: American Heart Association Scientific Sessions
  • Place of Presentation: Orlando, USA
  • Year and Date: 20091114-20091118
• [Presentation] Inflammasome activation in cardiac fibroblasts is essential for myocardial ischemia-reperfusion injury. (2009)
  • Author(s): Kawaguchi M, Takahashi M, Hata T, Kashima Y, Takahasni, Y, Sagara J, Taniguchi S, Ikeda U.
  • Organizer: American Heart Association Scientific Sessions
  • Place of Presentation: Orlando, USA
  • Year and Date: 20091114-20091118
• [Presentation] Role of inflammasome in cardiovascular diseases. (2009)
  • Author(s): Takahashi M.
  • Organizer: The Annual Scientific Conference of the Korean Society of Lipidology and Atherosclerosis (KSLA)
  • Place of Presentation: Seoul, South Korea
  • Year and Date: 20090904-20090905
• [Presentation] Th17 cells, a new subset of CD4^+ T-cells, plays an important role in angiogenic response to hindlimb ischemia. (2009)
  • Author(s): Takahashi M, Hata T, Kawaguchi M, Kashima Y, Hida S, Izawa A, Iwakura Y, Taki S, Ikeda U.
  • Organizer: 第15回日本遺伝子治療学会
  • Place of Presentation: 大阪
  • Year and Date: 20090709-20090711
• [Presentation] Role of an Inflammasome adaptor molecule ASC in myocardial ischemia-reperfusion injury. (2008)
  • Author(s): Kawaguchi M, Takahashi M, Hata T, Takahashi Y, Morimoto H, Ise H, Sagara J, Hongo M, Taniguchi S, Ikeda U.
  • Organizer: American Heart Association Scientific Sessions
  • Place of Presentation: New Orleans, USA
  • Year and Date: 20081108-20081112
• [Presentation] Critical role of Th17-CD4^+ T cells in angiogenic response to hindlimb ischemia in mice. (2008)
  • Author(s): Hata T, Takahashi M, Kawaguchi T, Kashima Y, Shiba Y, Ise H, Hida S, Iwakura Y, Taki S, Ikeda U.
  • Organizer: American Heart Association Scientific Sessions
  • Place of Presentation: New Orleans, USA
  • Year and Date: 20081108-20081112
• [Presentation] Double deficiency of tumor necrosis factor-α and Interferon-γ in bone marrow-derived cells prevents neointimal formation in a murine model of vascular injury. (2008)
  • Author(s): Murayama H, Takahashi M, Shiba Y, Ise H, Takamoto M, Tagawa Y, Iwakura Y, Ikeda U.
  • Organizer: American Heart Association Scientific Sessions
  • Place of Presentation: New Orleans, USA
  • Year and Date: 20081108-20081112
• [Remarks] 研究代表者ホームページ
  • URL: http://www.jichi.ac.jp/bioimaging/