2010 Fiscal Year Final Research Report
Role of phospholipids in the pathogenesis of respiratory failure mediated by highly pathogenic influenza virus infection
| Project/Area Number |
20200081
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
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| Allocation Type | Single-year Grants |
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| Research Field |
Emergency medicine
General pharmacology
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| Research Institution | Akita University |
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Principal Investigator |
IMAI Yumiko Akita University, 大学院・医学系研究科, 教授 (50231163)
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| Co-Investigator(Renkei-kenkyūsha) |
SASAKI Takehiko 秋田大学, 大学院・医学系研究科, 教授 (50333365)
SASAKI Junko 秋田大学, 大学院・医学系研究科, 講師 (30333371)
TAKASUGA Shunsuke 秋田大学, 大学院・医学系研究科, 助教 (90375262)
EGUCHI Satoshi 秋田大学, 大学院・医学系研究科, 助教 (70457117)
OHTEKI Toshiaki 東京医科歯科大学, 難治疾患研究所, 教授 (50233200)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 集中治療 / 呼吸不全 / ウイルス感染症 / 細胞膜イノシトールリン脂質 |
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| Research Abstract |
Since April 2009, a novel swine-origin influenza A (H1N1) virus has emerged, and is spreading rapidly among humans on a worldwide scale. Also, H5N1 avian influenza virus continues to cause outbreaks in poultry and sporadic infections in humans. The mortality rate of H5N1 avian influenza in humans has been as high as 60%. Most patients who died of the influenza developed the acute respiratory distress syndrome (ARDS), which is characterized by an extremely severe pulmonary inflammation and respiratory failure. Such patients with ARDS require critical cares including mechanical ventilation in the intensive care units (ICUs). In the present study, using mouse ICU model system, we examined the role of phosphatidylinositol pathway in the pathogenesis of ARDS mediated by influenza virus infection. We found that PI pathway, in particular PI3P related genes, were involved in the influenza virus replication and the pathogenesis of ARDS, suggest the critical role of endosomal PIs in the pathogenesis of severe influenza.
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Author(s)
Neely GG, Kuba K, Cammarato A, Isobe K, Amann S, Zhang L, Murata M, Elmen L, Gupta V, Arora S, Sarangi R, Dan D, Fujisawa S, Usami T, Xia CP, Keene AC, Alayari NN, Yamakawa H, Elling U, Berger C, Novatchkova M, Koglgruber R, Fukuda K, Nishina H, Isobe M, Pospisilik JA, Imai Y, Pfeufer A, Hicks AA, Pramstaller PP, Subramaniam S, Kimura A, Ocorr K, Bodmer R, Penninger JM.
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Journal Title
Cell. 141(1)
Pages: 142-153
Peer Reviewed
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[Journal Article] PI3Kgamma protects from myocardial ischemia and reperfusion injury through a kinase-independent pathway.2010
Author(s)
Haubner BJ, Neely GG, Voelkl JG, Damilano F, Kuba K, Imai Y, Komnenovic V, Mayr A, Pachinger O, Hirsch E, Penninger JM, Metzler B.
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Journal Title
PLoS One. 5(2)
Pages: e9350
Peer Reviewed
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[Journal Article] Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury.2008
Author(s)
Imai Y, Kuba K, Neely GG, Yaghubian-Malhami R, Perkmann T, van Loo G, Ermolaeva M, Veldhuizen R, Leung YH, Wang H, Liu H, Sun Y, Pasparakis M, Kopf M, Mech C, Bavari S, Peiris JS, Slutsky AS, Akira S, Hultqvist M, Holmdahl R, Nicholls J, Jiang C, Binder CJ, Penninger JM.
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Journal Title
Cell.18 133(2)
Pages: 235-249
Peer Reviewed
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