2012 Fiscal Year Final Research Report
Analyses of architecture and functions of cerebral networks by target neuron-selective activity suppression and tract-tracing approaches
| Project/Area Number |
20220006
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| Research Category |
Grant-in-Aid for Scientific Research (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neuroscience in general
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| Research Institution | Kyoto University (2009-2012)
Tokyo Metropolitan Organization for Medical Research (2008) |
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Principal Investigator |
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| Project Period (FY) |
2008 – 2012
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| Keywords | 神経科学 / 脳・神経 / ウイルスベクター / 大脳基底核 / 大脳皮質 / 神経回路 / 狂犬病ウイルス / 越シナプス的神経路トレーシング |
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| Research Abstract |
The present study was designed to develop two advanced methodological approaches to elucidation of structural bases for neural networks and to analyze the architecture and functions of the cortico-basal ganglia circuits in primates. First, we attempted target neuron-selective activity suppression using a novel lentiviral vector system and examined changes in behavioral pattern and neuronal activity in relation to motor tasks. Second, we established a novel system that achieved retrograde transneuronal tract-tracing with rabies virus and its recombinant vectors and investigated the organization of multisynaptic inputs to the prefrontal, premotor, and higher visual areas of the cortex.
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