2012 Fiscal Year Final Research Report
Study of IP_3 receptor/Ca^<2+> signaling in neural plasticity and brain development and differentiation
| Project/Area Number |
20220007
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| Research Category |
Grant-in-Aid for Scientific Research (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
MIKOSHIBA Katsuhiko 独立行政法人理化学研究所, 発生神経生物研究チーム, チームリーダー (30051840)
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| Project Period (FY) |
2008 – 2012
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| Keywords | 神経伝達物質 / 受容体 / IP_3 / カルシウム振動 / 小胞体ストレス / グリア細胞 / 自己免疫疾患 / 心疾患 / IRBIT |
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| Research Abstract |
IP_3 is important in cell signaling but requires the IP_3 receptor (IP_3R) to mediate all of its effects. Structural and biochemical studies indicate that the IP_3R provides a platform for molecules to interact, and combinations of associated molecules results which we discovered such as ERp44, GRP78, 80K-H et al, in functional diversity of cell signaling. IP_3Rs determine the trajectory of cell signaling by working as a signaling hub for interaction with differential molecular complexes which we discovered for various cell functions. The IP_3R signaling trajectory, in turn, plays a crucial role in cellular functions, in addition, IRBIT which is released from IP_3R as 3^<rd> messenger, also plays a variety of role. The abnormality of IP_3R signaling results in diseases such as neuronal degeneration, learning deficient, cardiogenesis abnormality, osteoporosis, auto-immune-disease, acute pancreatitis. We have developed ultra-sensitive genetically encoded Ca^<2+> indicator, Ca^<2+> pump indicator and established in vivo imaging of the cerebellum and cerebral cortex by two photon microscopy to study more in detail.
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[Journal Article] Mechanistic basis of bell-shaped dependence of inositol 1,4,5-trisphosphate receptor gating on cytosolic calcium2011
Author(s)
Shinohara T, Michikawa T, Enomoto M, Goto J, Iwai M, Matsu-ura T, Yamazaki H, Miyamoto A, Suzuki A, Mikoshiba K
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Journal Title
Proc. Natl. Acad. Sci
Volume: 108(37)
Pages: 15486-91
Peer Reviewed
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[Journal Article] Spontaneous network activity visualized by ultrasensitive Ca^<2+> indicators, yellow Cameleon-Nano2010
Author(s)
Horikawa K*, Yamada Y*, Matsuda T, Kobayashi K, Hashimoto M, Matsu-Ura T, Miyawaki A, Michikawa T, Mikoshiba K, Nagai T
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Journal Title
Nature Methods (*equal contribution)
Volume: 7(9)
Pages: 729-32
Peer Reviewed
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[Presentation]2012
Author(s)
Mikoshiba K
Organizer
カロリンスカ研究所セミナー
Place of Presentation
(ストックホルム) Lecture
Year and Date
2012-03-01
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[Presentation]2011
Author(s)
Mikoshiba K
Organizer
International Society for Neurochemistry (ISN) and the European Society for Neurochemistry (ESN) 23rd ISN-ESN Congress, Plenary Lecture (Athene, Greek) (2人のノーベル賞受賞者 Roger Tsien 教授 Linda Buck 教授と一緒に招待された.)
Year and Date
2011-09-01
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[Presentation]2011
Author(s)
Mikoshiba K
Organizer
Symposium Frontiers in Epithelial Transport 2011 (Yonsei Univeristy, Seoul Korea) Invited Speaker
Place of Presentation
Yonsei Univeristy, Seoul Korea
Year and Date
2011-04-14
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[Presentation]2008
Author(s)
Mikoshiba K
Organizer
Sherrington Lecture
Place of Presentation
Liverpool, England
Year and Date
2008-09-19
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[Remarks] (テレビ出演)NHK E テレ サイエンスZERO 『生命を動かす"魔法の金属"』30 分番組として御子柴の研究成果をとりあげてくれ、NHK へ出向き、出演した。また、研究室での取材もあった。 2011 年6 月25 日放送。英語版に直され、海外で2013 年5 月27 日に放映された。
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[Remarks] NHK E テレ サイエンスZERO 『バイオイメージングが医療を変える』研究室での取材内容が放映された。 2010 年12月4 日放送
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