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2012 Fiscal Year Final Research Report

Study of IP_3 receptor/Ca^<2+> signaling in neural plasticity and brain development and differentiation

Research Project

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Project/Area Number 20220007
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Neurochemistry/Neuropharmacology
Research InstitutionThe Institute of Physical and Chemical Research

Principal Investigator

MIKOSHIBA Katsuhiko  独立行政法人理化学研究所, 発生神経生物研究チーム, チームリーダー (30051840)

Project Period (FY) 2008 – 2012
Keywords神経伝達物質 / 受容体 / IP_3 / カルシウム振動 / 小胞体ストレス / グリア細胞 / 自己免疫疾患 / 心疾患 / IRBIT
Research Abstract

IP_3 is important in cell signaling but requires the IP_3 receptor (IP_3R) to mediate all of its effects. Structural and biochemical studies indicate that the IP_3R provides a platform for molecules to interact, and combinations of associated molecules results which we discovered such as ERp44, GRP78, 80K-H et al, in functional diversity of cell signaling. IP_3Rs determine the trajectory of cell signaling by working as a signaling hub for interaction with differential molecular complexes which we discovered for various cell functions. The IP_3R signaling trajectory, in turn, plays a crucial role in cellular functions, in addition, IRBIT which is released from IP_3R as 3^<rd> messenger, also plays a variety of role. The abnormality of IP_3R signaling results in diseases such as neuronal degeneration, learning deficient, cardiogenesis abnormality, osteoporosis, auto-immune-disease, acute pancreatitis. We have developed ultra-sensitive genetically encoded Ca^<2+> indicator, Ca^<2+> pump indicator and established in vivo imaging of the cerebellum and cerebral cortex by two photon microscopy to study more in detail.

  • Research Products

    (35 results)

All 2012 2011 2010 2009 2008 Other

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (12 results) Book (2 results) Remarks (4 results) Patent(Industrial Property Rights) (8 results) (of which Overseas: 2 results)

  • [Journal Article] Revisiting Channel Allostery: A Coherent Mechanism in IP_3 and Ryanodine Receptors2012

    • Author(s)
      Hamada K, Mikoshiba K
    • Journal Title

      Science Signaling

      Volume: 5(225) Pages: 24

    • Peer Reviewed
  • [Journal Article] Receptor-selective diffusion barrier enhances sensitivity of astrocytic processes to metabotropic glutamate receptor stimulation2012

    • Author(s)
      Arizono M, Bannai H, Nakamura K, Niwa F, Enomoto M, Matsu-Ura T, Miyamoto A, Sherwood MW, Nakamura T, Mikoshiba K
    • Journal Title

      Science Signaling

      Volume: 218 Pages: ra27

    • Peer Reviewed
  • [Journal Article] Mechanistic basis of bell-shaped dependence of inositol 1,4,5-trisphosphate receptor gating on cytosolic calcium2011

    • Author(s)
      Shinohara T, Michikawa T, Enomoto M, Goto J, Iwai M, Matsu-ura T, Yamazaki H, Miyamoto A, Suzuki A, Mikoshiba K
    • Journal Title

      Proc. Natl. Acad. Sci

      Volume: 108(37) Pages: 15486-91

    • Peer Reviewed
  • [Journal Article] Syntaxin 1B suppresses macropinocytosis and semaphorin 3A-induced growth cone collapse2011

    • Author(s)
      Kabayama H, Takeuchi M, Taniguchi M, Tokushige N, Kozaki S, Mizutani A, Nakamura T, Mikoshiba K
    • Journal Title

      J. Neuroscience

      Volume: 31(20) Pages: 7357-64

    • Peer Reviewed
  • [Journal Article] Spontaneous network activity visualized by ultrasensitive Ca^<2+> indicators, yellow Cameleon-Nano2010

    • Author(s)
      Horikawa K*, Yamada Y*, Matsuda T, Kobayashi K, Hashimoto M, Matsu-Ura T, Miyawaki A, Michikawa T, Mikoshiba K, Nagai T
    • Journal Title

      Nature Methods (*equal contribution)

      Volume: 7(9) Pages: 729-32

    • Peer Reviewed
  • [Journal Article] Mechanism of ER stress-induced brain damage by IP3 receptor2010

    • Author(s)
      Higo T, Hamada K, Nakamura T, Hattori M, Mikoshiba K
    • Journal Title

      Neuron (表紙に採用)

      Volume: 68(5) Pages: 865-878

    • Peer Reviewed
  • [Journal Article] Triller A. Activity-dependent tuning of inhibitory neurotransmission based on GABAAR diffusion dynamics2009

    • Author(s)
      Bannai H, Levi S, Schweizer C, Inoue T, Launey T, Racine V, Sibarita JB, Mikoshiba K
    • Journal Title

      Neuron

      Volume: 62(5) Pages: 670-82

    • Peer Reviewed
  • [Journal Article] Control of Neuronal Growth Cone Navigation by Asymmetric Inositol 1,4,5-Trisphosphate Signals2009

    • Author(s)
      Akiyama H, Matsu-ura T, Mikoshiba K, and Kamiguchi H
    • Journal Title

      Science Signaling

      Volume: 2(79) Pages: ra34

    • Peer Reviewed
  • [Journal Article] Osteoblasts induce Ca^<2+> oscillation-independent NFATc1 activation during osteoclastogenesis2008

    • Author(s)
      Kuroda Y., Hisatsune C., …Mikoshiba K
    • Journal Title

      Proc. Natl. Acad. Sci

      Volume: 105(25) Pages: 8643-8648

    • Peer Reviewed
  • [Presentation]2012

    • Author(s)
      Mikoshiba K
    • Organizer
      1st Asia Dry Eye Society Advisory Board Meeting
    • Place of Presentation
      (ホテルペニンスラ、東京), Special Lecture
    • Year and Date
      2012-12-01
  • [Presentation]2012

    • Author(s)
      Mikoshiba K
    • Organizer
      FASEB 会議 招待講演
    • Year and Date
      2012-06-20
  • [Presentation]2012

    • Author(s)
      Mikoshiba K
    • Organizer
      カロリンスカ研究所セミナー
    • Place of Presentation
      (ストックホルム) Lecture
    • Year and Date
      2012-03-01
  • [Presentation]2011

    • Author(s)
      Mikoshiba K
    • Organizer
      Ion Channel Signaling Mechanisms: From Basic Science to Clinical Application, Plenary Talk
    • Place of Presentation
      Marrakesh, Morocco
    • Year and Date
      2011-10-31
  • [Presentation]2011

    • Author(s)
      Mikoshiba K
    • Organizer
      International Society for Neurochemistry (ISN) and the European Society for Neurochemistry (ESN) 23rd ISN-ESN Congress, Plenary Lecture (Athene, Greek) (2人のノーベル賞受賞者 Roger Tsien 教授 Linda Buck 教授と一緒に招待された.)
    • Year and Date
      2011-09-01
  • [Presentation]2011

    • Author(s)
      Mikoshiba K
    • Organizer
      The 17th International Symposium on Ca^<2+>-Binding Proteins and Ca^<2+> Function in Health and Disease, Plenary Lecture
    • Place of Presentation
      北京、中国
    • Year and Date
      2011-07-20
  • [Presentation]2011

    • Author(s)
      Mikoshiba K
    • Organizer
      World Class Univerisity (WCU) Professor プログラムLecture
    • Place of Presentation
      ソウル国立大学、韓国
    • Year and Date
      2011-04-28
  • [Presentation]2011

    • Author(s)
      Mikoshiba K
    • Organizer
      Symposium Frontiers in Epithelial Transport 2011 (Yonsei Univeristy, Seoul Korea) Invited Speaker
    • Place of Presentation
      Yonsei Univeristy, Seoul Korea
    • Year and Date
      2011-04-14
  • [Presentation]2010

    • Author(s)
      Mikoshiba K
    • Organizer
      FASEB Summer Research Conference(Corolado, USA)Invited Speaker
    • Place of Presentation
      Corolado, USA
    • Year and Date
      2010-06-15
  • [Presentation]2009

    • Author(s)
      Mikoshiba K
    • Organizer
      Plenary Lecture, 16^<th>Symposium on Ca^<2+>- Binding Proteins and Ca^<2+> Function in Health and Disease (Puchon, Chille)
    • Place of Presentation
      Puchon, Chille
    • Year and Date
      2009-11-16
  • [Presentation]2009

    • Author(s)
      Mikoshiba K
    • Organizer
      第36回国際生理学会(IUPS09)シンポジウム(京都)Symposium Lecture
    • Place of Presentation
      京都
    • Year and Date
      2009-08-01
  • [Presentation]2008

    • Author(s)
      Mikoshiba K
    • Organizer
      Sherrington Lecture
    • Place of Presentation
      Liverpool, England
    • Year and Date
      2008-09-19
  • [Book] Isolation of Inositol 1,4,5-Trisphosphate Receptor-Associating Protein and Selective Knockdown "Using RNA Interference Inositol Phosphates and Lipids - Methods and Protocols- Chapter 92010

    • Author(s)
      Mizutani A, Kawaai K, Hisatsune C, Ando H, Michikawa T, Mikoshiba K
    • Total Pages
      133-141
    • Publisher
      The Humana Press Inc
  • [Book] Springer, Handbook of "Neurochemistry and Molecular Neurobiology 3rd Edition .Neural Signaling Mechanisms- Cyclin-Dependent Kinase 5 (御子柴がエディターであり、3 Chapter の著者である)2009

    • Author(s)
      Mikoshiba K
    • Total Pages
      631
    • Publisher
      Springer
  • [Remarks] (ポッドキャスト) Science Signaling Podcast(サイエンス誌のオフィスからの電話の会話が放送された)

    • URL

      http://www.brain.riken.jp/jp/faculty/details/29

  • [Remarks]

    • URL

      http://stke.sciencemag.org/cgi/content/full/sigtrans;5/219/pc8

  • [Remarks] (テレビ出演)NHK E テレ サイエンスZERO 『生命を動かす"魔法の金属"』30 分番組として御子柴の研究成果をとりあげてくれ、NHK へ出向き、出演した。また、研究室での取材もあった。 2011 年6 月25 日放送。英語版に直され、海外で2013 年5 月27 日に放映された。

  • [Remarks] NHK E テレ サイエンスZERO 『バイオイメージングが医療を変える』研究室での取材内容が放映された。 2010 年12月4 日放送

  • [Patent(Industrial Property Rights)] IP_3 受容体結合蛋白質による細胞内標的分子の制御2012

    • Inventor(s)
      御子柴克彦、安東英明、水谷顕洋
    • Industrial Property Rights Holder
      御子柴克彦、安東英明、水谷顕洋
    • Industrial Property Number
      特許2007-73396
    • Acquisition Date
      2012-08-28
    • Overseas
  • [Patent(Industrial Property Rights)] 小胞体カルシウムATP アーゼ2011

    • Inventor(s)
      御子柴克彦、松浦徹、佐藤嘉名与
    • Industrial Property Rights Holder
      御子柴克彦、松浦徹、佐藤嘉名与
    • Industrial Property Number
      特許2011-005797
    • Filing Date
      2011-01-14
  • [Patent(Industrial Property Rights)] マラリアの治療方法、マラリア原虫の殺虫方法、及びその利用2011

    • Inventor(s)
      御子柴克彦、榎本匡宏、河津信一郎
    • Industrial Property Rights Holder
      御子柴克彦、榎本匡宏、河津信一郎
    • Industrial Property Number
      特許JP2011/074876
    • Filing Date
      2011-11-10
  • [Patent(Industrial Property Rights)] IP_3 指示薬2011

    • Inventor(s)
      御子柴克彦、松浦徹、道川貴章、井上貴文
    • Industrial Property Rights Holder
      御子柴克彦、松浦徹、道川貴章、井上貴文
    • Industrial Property Number
      特願2004-309686
    • Acquisition Date
      2011-08-26
  • [Patent(Industrial Property Rights)] 新規ビスホウ素化合物2011

    • Inventor(s)
      御子柴克彦、尾崎庄一郎、鈴木商信、中村健
    • Industrial Property Rights Holder
      御子柴克彦、尾崎庄一郎、鈴木商信、中村健
    • Industrial Property Number
      特許US8017809B2
    • Acquisition Date
      2011-09-13
    • Overseas
  • [Patent(Industrial Property Rights)] 蛋白質阻害剤2010

    • Inventor(s)
      御子柴克彦、濱田耕造、寺内明子
    • Industrial Property Rights Holder
      御子柴克彦、濱田耕造、寺内明子
    • Industrial Property Number
      特許2010-90527
    • Filing Date
      2010-04-09
  • [Patent(Industrial Property Rights)] 蛋白質阻害剤2009

    • Inventor(s)
      御子柴克彦、貫名信行、尾崎庄一郎、濱田耕造、後藤純一、鈴木商信、戎井悦子、寺内明子
    • Industrial Property Rights Holder
      御子柴克彦、貫名信行、尾崎庄一郎、濱田耕造、後藤純一、鈴木商信、戎井悦子、寺内明子
    • Industrial Property Number
      特許JP2009/064206
    • Filing Date
      2009-08-11
  • [Patent(Industrial Property Rights)] 蛋白質架橋阻害剤およびその用途2009

    • Inventor(s)
      御子柴克彦、貫名信行、尾崎庄一郎、濱田耕造、後藤純一、鈴木商信、戎井悦子、寺内明子
    • Industrial Property Rights Holder
      御子柴克彦、貫名信行、尾崎庄一郎、濱田耕造、後藤純一、鈴木商信、戎井悦子、寺内明子
    • Industrial Property Number
      特許2009-255518
    • Filing Date
      2009-11-06

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Published: 2014-08-29   Modified: 2014-09-05  

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