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2012 Fiscal Year Final Research Report

MOLECULAR MECHANISMS UNDERLYING CELL POLARIZATION IN MIGRATING CELLS AND NEURONS

Research Project

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Project/Area Number 20227006
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Cell biology
Research InstitutionNagoya University

Principal Investigator

KAIBUCHI Kozo  名古屋大学, 医学系研究科, 教授 (00169377)

Co-Investigator(Kenkyū-buntansha) AMANO Mutsuki  名古屋大学, 大学院・医学系研究科, 准教授 (90304170)
WATANABE Takashi  名古屋大学, 大学院・医学系研究科, 特任講師 (10402562)
MORI Daisuke  名古屋大学, 大学院・医学系研究科, 特任講師 (00381997)
NISHIOKA Tomoki  名古屋大学, 大学院・医学系研究科, 助教 (70435105)
TSUBOI Daisuke  名古屋大学, 大学院・医学系研究科, 助教 (80584672)
ARIMURA Nariko  名古屋大学, 大学院・医学系研究科, 助教 (20420375)
Project Period (FY) 2008 – 2012
Keywordsシグナル伝達 / 遊走 / 細胞骨格 / 極性 / プロテオーム / 微小管 / 脳・神経 / 小胞輸送
Research Abstract

In response to extracellular and intracellular signals, cell exhibits a polarized morphology with adhering neighboring cells and extracellular matrix. Cell polarization is a fundamental process that makes cells enable to exert specific physiological roles in tissues. The understanding for the molecular mechanisms by which cell polarization isregulated had remained largely unknown. Our researches revealed signaling networks for cellular polarization and its maintenance in migrating cells and neurons.

  • Research Products

    (30 results)

All 2013 2012 2011 2010 2009 2008 Other

All Journal Article (14 results) (of which Peer Reviewed: 14 results) Presentation (14 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Tiam1 interaction with the PAR complex promotes talin-mediated Rac1 activation during polarized cell migration.2012

    • Author(s)
      Wang S., Watanabe T., Matsuzawa K., Katsumi A., Kakeno M., Matsui T., Ye F., Sato K., Murase K., Sugiyama I., Kimura K., Mizoguchi A., Ginsberg M. H., Collard J. G. & Kaibuchi K.
    • Journal Title

      J Cell Biol

      Volume: 199 Pages: 331-345

    • Peer Reviewed
  • [Journal Article] Proteomic Screening for Rho-kinase Substrates by Combining Kinase and Phosphatase Inhibitors with 14-3-3zeta Affinity Chromatography.2012

    • Author(s)
      Nishioka T., Nakayama M., Amano M. & Kaibuchi K.
    • Journal Title

      Cell Struct Funct

      Volume: 37 Pages: 39-48

    • Peer Reviewed
  • [Journal Article] The inositol 5-phosphatase SHIP2 is an effector of RhoA and is involved in cell polarity and migration.2012

    • Author(s)
      Kato K., Yazawa T., Taki K., Mori K., Wang S., Nishioka T., Hamaguchi T., Itoh T., Takenawa T., Kataoka C., Matsuura Y., Amano M., Murohara T. & Kaibuchi K.
    • Journal Title

      Mol Biol Cell

      Volume: 23 Pages: 2593-2604

    • Peer Reviewed
  • [Journal Article] Flexible search for single-axon morphology during neuronal spontaneous polarization.2011

    • Author(s)
      Naoki H., Nakamuta S., Kaibuchi K. & Ishii S.
    • Journal Title

      PLoS One

      Volume: 6 Pages: e19034

    • Peer Reviewed
  • [Journal Article] The role of selective transport in neuronal polarization.2011

    • Author(s)
      Namba T., Nakamuta S., Funahashi Y. & Kaibuchi K.
    • Journal Title

      Dev Neurobiol

      Volume: 71 Pages: 445-457

    • Peer Reviewed
  • [Journal Article] Local application of neurotrophins specifies axons through inositol 1,4,5-trisphosphate, calcium, and Ca^/calmodulin-dependent protein kinases.2011

    • Author(s)
      Nakamuta S., Funahashi Y., Namba T., Arimura N., Picciotto M. R., Tokumitsu H., Soderling T. R., Sakakibara A., Miyata T., Kamiguchi H. & Kaibuchi K.
    • Journal Title

      Sci Signal

      Volume: 4 Pages: ra76

    • Peer Reviewed
  • [Journal Article] AMPK controls the speed of microtubule polymerization and directional cell migration through CLIP-170 phosphorylation.2010

    • Author(s)
      Nakano A., Kato H., Watanabe T., Min K. D., Yamazaki S., Asano Y., Seguchi O., Higo S., Shintani Y., Asanuma H., Asakura M., Minamino T., Kaibuchi K., Mochizuki N., Kitakaze M. & Takashima S
    • Journal Title

      Nat Cell Biol

      Volume: 12 Pages: 583-590

    • Peer Reviewed
  • [Journal Article] Identification of focal adhesion kinase (FAK) and phosphatidylinositol 3-kinase (PI3-kinase) as Par3 partners by proteomic analysis.2010

    • Author(s)
      Itoh N., Nakayama M., Nishimura T., Fujisue S., Nishioka T., Watanabe T. & Kaibuchi K.
    • Journal Title

      Cytoskeleton (Hoboken)

      Volume: 67 Pages: 297-308

    • Peer Reviewed
  • [Journal Article] A proteomic approach for comprehensively screening substrates of protein kinases such as Rho-kinase.2010

    • Author(s)
      Amano M., Tsumura Y., Taki K., Harada H., Mori K., Nishioka T., Kato K., Suzuki T., Nishioka Y., Iwamatsu A. & Kaibuchi K.
    • Journal Title

      PLoS One

      Volume: 5 Pages: e8704

    • Peer Reviewed
  • [Journal Article] Rho-kinase/ROCK: A key regulator of the cytoskeleton and cell polarity.2010

    • Author(s)
      Amano M., Nakayama M. & Kaibuchi K.
    • Journal Title

      Cytoskeleton (Hoboken)

      Volume: 67 Pages: 545-554

    • Peer Reviewed
  • [Journal Article] Phosphorylation of CLASP2 by GSK-3beta regulates its interaction with IQGAP1, EB1 and microtubules.2009

    • Author(s)
      Watanabe T., Noritake J., Kakeno M., Matsui T., Harada T., Wang S., Itoh N., Sato K., Matsuzawa K., Iwamatsu A., Galjart N. & Kaibuchi K.
    • Journal Title

      J Cell Sci

      Volume: 122 Pages: 2969-2979

    • Peer Reviewed
  • [Journal Article] Rho-kinase Contributes to Sustained RhoA Activation through Phosphorylation of p190A RhoGAP2009

    • Author(s)
      Mori K., Amano M., Takefuji M., Kato K., Morita Y., Nishioka T., Matsuura Y., Murohara T. & Kaibuchi K.
    • Journal Title

      J Biol Chem

      Volume: 284 Pages: 5067-5076

    • Peer Reviewed
  • [Journal Article] Anterograde transport of TrkB in axons is mediated by direct interaction with Slp1 and Rab272009

    • Author(s)
      Arimura N., Kimura T., Nakamuta S., Taya S., Funahashi Y., Hattori A., Shimada A., Menager C., Kawabata S., Fujii K., Iwamatsu A., Segal R. A., Fukuda M. & Kaibuchi K.
    • Journal Title

      Dev Cell

      Volume: 16 Pages: 675-686

    • Peer Reviewed
  • [Journal Article] CRMP-2 directly binds to cytoplasmic dynein and interferes with its activity.2009

    • Author(s)
      Arimura N., Hattori A., Kimura T., Nakamuta S., Funahashi Y., Hirotsune S., Furuta K., Urano T., Toyoshima Y. Y. & Kaibuchi K.
    • Journal Title

      J Neurochem

      Volume: 111 Pages: 380-390

    • Peer Reviewed
  • [Presentation] Neuronal Polarity in vitro and in vivo2013

    • Author(s)
      Kaibuchi K
    • Organizer
      Keystone Symposium
    • Place of Presentation
      Tahoe City, USA
    • Year and Date
      2013-03-11
  • [Presentation] Signaling for neuronal polarization2011

    • Author(s)
      Kaibuchi K
    • Organizer
      2011 Taiwan-Japan Joint Symposium on Cell Signaling and Gene Regulation
    • Place of Presentation
      Tainan, Taiwan
    • Year and Date
      2011-11-19
  • [Presentation] Tiam1 acts with the PAR complex to control talin-mediated Rac1 activation2011

    • Author(s)
      Kaibuchi K
    • Organizer
      5th Mechanobiology Conference
    • Place of Presentation
      Singapore
    • Year and Date
      2011-11-10
  • [Presentation] Neurotrophins regulate neuronal polarity acting through Ca^ and CaMKK. EMBO Cell Biology of the Neuron: Polarity2011

    • Author(s)
      Kaibuchi K
    • Organizer
      Plasticity and Regeneration
    • Place of Presentation
      Creta, Greece
    • Year and Date
      2011-05-09
  • [Presentation] Neurotrophins specify axonal fate of hippocampal neurons acting through inositol 1, 4, 5-triphosphate and Ca^2011

    • Author(s)
      Kaibuchi K
    • Organizer
      Emerging Concepts on Neuronal Cytoskelton
    • Place of Presentation
      Santa Cruz, Chile
    • Year and Date
      2011-04-25
  • [Presentation] Neuronal polarity-From extracellular signals to intracellular mechanisms. Cold Spring Harbor Asia Conference2010

    • Author(s)
      Kaibuchi K
    • Organizer
      1st Francis Crick Neuroscience Symposium
    • Place of Presentation
      Suzhou, China
    • Year and Date
      2010-04-13
  • [Presentation] Axon formation and polarized vesicle transport2009

    • Author(s)
      Kaibuchi K
    • Organizer
      BMB 2008
    • Place of Presentation
      神戸国際会議場 神戸
    • Year and Date
      2009-12-11
  • [Presentation] Role of Par and Tiam1 complex in polarized cell migration2009

    • Author(s)
      Kaibuchi K
    • Organizer
      RAMIC, National Network on Cell Adhesion and Migration
    • Place of Presentation
      Madrid, Spain
    • Year and Date
      2009-10-22
  • [Presentation] Neuronal polarity: From extracellular signals to intracellular mechanisms2009

    • Author(s)
      Kaibuchi K
    • Organizer
      第32回日本神経科学会
    • Place of Presentation
      名古屋国際会議場 名古屋
    • Year and Date
      2009-09-18
  • [Presentation] Roles of Rho family GTPases and Par proteins in directional migration2009

    • Author(s)
      Kaibuchi K
    • Organizer
      Gordon Research Conferences
    • Place of Presentation
      Oxford, UK
    • Year and Date
      2009-08-24
  • [Presentation] Axon formation and polarized vesicle transport2009

    • Author(s)
      Kaibuchi K
    • Organizer
      ESF-EMBO Symposium
    • Place of Presentation
      Sant Feliu de Guixols, Spain
    • Year and Date
      2009-05-23
  • [Presentation] Rho Proteins and Neuronal Polarity2008

    • Author(s)
      Kaibuchi K
    • Organizer
      FASEB Summer Research Conferences
    • Place of Presentation
      Vermont, USA
    • Year and Date
      2008-07-16
  • [Presentation] 細胞遊走における Rho ファミリーと Par 複合体の役割2008

    • Author(s)
      貝淵弘三
    • Organizer
      第60回日本細胞生物学会大会
    • Place of Presentation
      パシフィコ横浜 横浜
    • Year and Date
      2008-06-30
  • [Presentation] Neuronal development and cargo transport2008

    • Author(s)
      Kaibuchi K
    • Organizer
      Gordon Research Conference on Molecular & Cellular Neurobiology
    • Place of Presentation
      Hong Kong, China
    • Year and Date
      2008-06-10
  • [Book] Cadherin-mediated Intercellular Adhesion and Signaling Cascades Involving Small GTPases2009

    • Author(s)
      Watanabe T., Sato K., and Kaibuchi K.
    • Total Pages
      1:a003020
    • Publisher
      Cold Spring Harb Perspect Biol.
  • [Remarks]

    • URL

      http://www.med.nagoya-u.ac.jp/Yakuri/index.htm

URL: 

Published: 2014-08-29  

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