2012 Fiscal Year Final Research Report
MOLECULAR MECHANISMS UNDERLYING CELL POLARIZATION IN MIGRATING CELLS AND NEURONS
| Project/Area Number |
20227006
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| Research Category |
Grant-in-Aid for Scientific Research (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cell biology
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| Research Institution | Nagoya University |
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Principal Investigator |
KAIBUCHI Kozo 名古屋大学, 医学系研究科, 教授 (00169377)
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| Co-Investigator(Kenkyū-buntansha) |
AMANO Mutsuki 名古屋大学, 大学院・医学系研究科, 准教授 (90304170)
WATANABE Takashi 名古屋大学, 大学院・医学系研究科, 特任講師 (10402562)
MORI Daisuke 名古屋大学, 大学院・医学系研究科, 特任講師 (00381997)
NISHIOKA Tomoki 名古屋大学, 大学院・医学系研究科, 助教 (70435105)
TSUBOI Daisuke 名古屋大学, 大学院・医学系研究科, 助教 (80584672)
ARIMURA Nariko 名古屋大学, 大学院・医学系研究科, 助教 (20420375)
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| Project Period (FY) |
2008 – 2012
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| Keywords | シグナル伝達 / 遊走 / 細胞骨格 / 極性 / プロテオーム / 微小管 / 脳・神経 / 小胞輸送 |
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| Research Abstract |
In response to extracellular and intracellular signals, cell exhibits a polarized morphology with adhering neighboring cells and extracellular matrix. Cell polarization is a fundamental process that makes cells enable to exert specific physiological roles in tissues. The understanding for the molecular mechanisms by which cell polarization isregulated had remained largely unknown. Our researches revealed signaling networks for cellular polarization and its maintenance in migrating cells and neurons.
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[Journal Article] Tiam1 interaction with the PAR complex promotes talin-mediated Rac1 activation during polarized cell migration.2012
Author(s)
Wang S., Watanabe T., Matsuzawa K., Katsumi A., Kakeno M., Matsui T., Ye F., Sato K., Murase K., Sugiyama I., Kimura K., Mizoguchi A., Ginsberg M. H., Collard J. G. & Kaibuchi K.
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Journal Title
J Cell Biol
Volume: 199
Pages: 331-345
Peer Reviewed
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[Journal Article] The inositol 5-phosphatase SHIP2 is an effector of RhoA and is involved in cell polarity and migration.2012
Author(s)
Kato K., Yazawa T., Taki K., Mori K., Wang S., Nishioka T., Hamaguchi T., Itoh T., Takenawa T., Kataoka C., Matsuura Y., Amano M., Murohara T. & Kaibuchi K.
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Journal Title
Mol Biol Cell
Volume: 23
Pages: 2593-2604
Peer Reviewed
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[Journal Article] Local application of neurotrophins specifies axons through inositol 1,4,5-trisphosphate, calcium, and Ca^/calmodulin-dependent protein kinases.2011
Author(s)
Nakamuta S., Funahashi Y., Namba T., Arimura N., Picciotto M. R., Tokumitsu H., Soderling T. R., Sakakibara A., Miyata T., Kamiguchi H. & Kaibuchi K.
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Journal Title
Sci Signal
Volume: 4
Pages: ra76
Peer Reviewed
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[Journal Article] AMPK controls the speed of microtubule polymerization and directional cell migration through CLIP-170 phosphorylation.2010
Author(s)
Nakano A., Kato H., Watanabe T., Min K. D., Yamazaki S., Asano Y., Seguchi O., Higo S., Shintani Y., Asanuma H., Asakura M., Minamino T., Kaibuchi K., Mochizuki N., Kitakaze M. & Takashima S
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Journal Title
Nat Cell Biol
Volume: 12
Pages: 583-590
Peer Reviewed
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[Journal Article] Phosphorylation of CLASP2 by GSK-3beta regulates its interaction with IQGAP1, EB1 and microtubules.2009
Author(s)
Watanabe T., Noritake J., Kakeno M., Matsui T., Harada T., Wang S., Itoh N., Sato K., Matsuzawa K., Iwamatsu A., Galjart N. & Kaibuchi K.
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Journal Title
J Cell Sci
Volume: 122
Pages: 2969-2979
Peer Reviewed
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[Journal Article] Anterograde transport of TrkB in axons is mediated by direct interaction with Slp1 and Rab272009
Author(s)
Arimura N., Kimura T., Nakamuta S., Taya S., Funahashi Y., Hattori A., Shimada A., Menager C., Kawabata S., Fujii K., Iwamatsu A., Segal R. A., Fukuda M. & Kaibuchi K.
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Journal Title
Dev Cell
Volume: 16
Pages: 675-686
Peer Reviewed
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