Integrated elucidation of metabolic pathway in the physiology and pathology.

2010 Fiscal Year Self-evaluation Report

• Project/Area Number: 20229008
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: Metabolomics
• Research Institution: The University of Tokyo
• Principal Investigator: KADOWAKI Takashi The University of Tokyo, 医学部・附属病院, 教授 (30185889)
• Project Period (FY): 2008 – 2012
• Keywords: アディポネクチン / インスリン / AdipoR / 糖代謝 / 脂質代謝

Research Abstract

糖・脂質・エネルギー代謝は生命発現にとって極めて重要である。インスリン(Ins)とアディポネクチン(Ad)はこれら代謝制御の2大経路である。我国で死因一位の心血管疾患の主因である糖尿病・メタボリックシンドロームの激増の原因解明と治療法開発には、代謝制御とその破綻の統合的理解が不可欠である。本研究では、各組織でのAd 作用を解明出来る組織特異的Ad 受容体(AdipoR)欠損マウスとIns作用を各組織でプライマリーに欠損させた効果を解明出来る組織特異的Ins受容体基質(IRS)欠損マウスを駆使し、中枢・末梢の各組織及び全身におけるAd とIns作用の全容解明を中心にして、代謝制御機構の統合的理解とその破綻の改善法開発に至るまでの(1)代謝制御における臓器間クロストークのメカニズム解明及び(2)代謝制御における細胞機能・恒常性のメカニズムの解明を目的とする。

Research Products

• [Journal Article] Adiponectin enhances insulin sensitivity by increasing hepatic IRS-2 expression via macrophage-derived IL-6 dependent pathway. (2011)
  • Author(s): Awazawa M, Ueki K, Inabe K, Yamauchi T, Kubota N, Kaneko K, Kobayashi M, Iwane A, Sasako T, Ohsugi M, Takamoto I, Yamashita S, Asahara H, Akira S, Kasuga M, Kadowaki T
  • Journal Title: Cell Metabolism 13 Pages: 401-412
• [Journal Article] Impaired insulin signaling in the endothelial cells reduces insulin-induced glucose uptake by the skeletal muscle. (2011)
  • Author(s): Kubota T, Kubota N, Kumagai H, Yamaguchi S, Kozono H, Takahashi T, Inoue M, Itoh S, Takamoto I, Sasako T, Kumagai K, Kawai T, Hashimoto S, Kobayashi T, Sato M, Tokuyama K, Nishimura S, Tsunoda M, Ide T, Murakami K, Yamazaki T, Ezaki O, Kawamura K, Masuda H, Moroi M, Sugi K, Oike Y, Shimokawa H, Yanagihara N, Tsutsui M, Terauchi Y, Tobe K, Nagai R, Kamata K, Inoue K, Kodama T, Ueki K, Kadowaki T
  • Journal Title: Cell Metabolism 13 Pages: 294-307
• [Journal Article] Class IA phosphatidylinositol 3-kinase in pancreatic b cells controls insulin secretion by multiple mechanisms. (2010)
  • Author(s): Kaneko K, Ueki K, Takahashi N, Hashimoto S, Okamoto M, Awazawa M, Okazaki Y, Ohsugi M, Inabe K, Umehara T, Yoshida M, Kakei M, Kitamura T, Luo J, Kulkami RN, Kahn CR, Kasai H, Cantley LC, Kadowaki T
  • Journal Title: Cell Metabolism 12 Pages: 619-632
• [Journal Article] Adiponectin and AdipoR1 regulate PGC1・and mitochondria by Ca^<2+> and AMPK/SIRT1. (2010)
  • Author(s): Iwabu M, Yamauchi T, Okada-Iwabu M, Sato K, Nakagawa T, Funata M, Yamaguchi M, Namiki S, Nakayama R, Tabata M, Ogata H, Kubota N, Takamoto I, Hayashi YK, Yamauchi N, Waki H, Fukayama M, Nishino I, Tokuyama K, Ueki K, Oike Y, Ishii S, Hirose K, Shimizu T, Touhara K, Kadowaki T
  • Journal Title: Nature 464 Pages: 1313-1319
• [Journal Article] Dynamic functional relay between insulin receptor substrate-1 and -2 in hepatic insulin signaling during fasting and feeding. (2008)
  • Author(s): Kubota N, Kubota T, Itoh S, Kumagai H, Kozono H, Takamoto I, Mineyama T, Ogata H, Tokuyama K, Ohsugi M, Sasako T, Moroi M, Sugi K, Kakuta S, Iwakura Y, Noda T, Ohnishi S, Nagai R, Tobe K, Terauchi Y, Ueki K, Kadowaki T
  • Journal Title: Cell Metabolism 8 Pages: 49-64
• [Presentation] Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca2+ signalling and AMPK/SIRT1 like exercise. (2010)
  • Author(s): Yamauchi T, Iwabu M, Okada-Iwabu M, Ueki K, Kadowaki T
  • Organizer: 46^<th> Annual Meeting of the European Association for the Study of Diabetes.
  • Place of Presentation: Stockholm
  • Year and Date: 2010-09-22
• [Presentation] Role of adiponectin/AdipoR1 in skeletal muscle in mitochondrial biogenesis, exercise endurance and insulin sensitivity. (2010)
  • Author(s): Kadowaki T
  • Organizer: The 14th International Congress of Endocrinology(ICE2010)
  • Place of Presentation: 京都
  • Year and Date: 2010-03-28
• [Presentation] Adipocyte. (2009)
  • Author(s): Kadowaki T
  • Organizer: 20^<th> World Diabetes Congress(IDF)
  • Place of Presentation: Montreal
  • Year and Date: 2009-10-20
• [Presentation] The Rule of IRS2 in Hepatic Insulin Sensitivity. (2009)
  • Author(s): Kadowaki T
  • Organizer: American Diabetes Association 69^<th> Scientific Sessions
  • Place of Presentation: Louisiana
  • Year and Date: 2009-06-06
• [Presentation] Epidemic of type 2 diabetes in Japan-Its causes and preventive strategies. (2009)
  • Author(s): Kadowaki T
  • Organizer: 3^<rd> International Congress on Prediabetes and the Metabolic Syndrome.
  • Place of Presentation: Nice
  • Year and Date: 2009-04-02
• [Remarks]
  • URL: http://dm301k.umin.jp/