Integrated elucidation of metabolic pathway in the physiology and pathology

• Project/Area Number: 20229008
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: Metabolomics
• Research Institution: The University of Tokyo
• Principal Investigator: KADOWAKI Takashi 東京大学, 医学部附属病院, 教授 (30185889)
• Co-Investigator(Kenkyū-buntansha): UEKI Kohjiro 東京大学, 医学部附属病院, 准教授 (00396714) ; YAMAUCHI Toshimasa 東京大学, 医学部附属病院, 講師 (40372370)
• Co-Investigator(Renkei-kenkyūsha): HARA Kazuo 東京大学, 医学部附属病院, 特任准教授 (50359600) ; KUBOTA Naoto 東京大学, 医学部附属病院, 特任准教授 (50396719)
• Project Period (FY): 2008 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥227,240,000 (Direct Cost: ¥174,800,000、Indirect Cost: ¥52,440,000); Fiscal Year 2012: ¥28,080,000 (Direct Cost: ¥21,600,000、Indirect Cost: ¥6,480,000); Fiscal Year 2011: ¥28,080,000 (Direct Cost: ¥21,600,000、Indirect Cost: ¥6,480,000); Fiscal Year 2010: ¥28,080,000 (Direct Cost: ¥21,600,000、Indirect Cost: ¥6,480,000); Fiscal Year 2009: ¥41,600,000 (Direct Cost: ¥32,000,000、Indirect Cost: ¥9,600,000); Fiscal Year 2008: ¥101,400,000 (Direct Cost: ¥78,000,000、Indirect Cost: ¥23,400,000)
• Keywords: アディポネクチン / インスリン / AdipoR / 糖代謝 / 脂質代謝

Research Abstract

An integrated understanding of metabolic regulation and its disruption is essential in elucidating the pathophysiology of diabetes and the metabolic syndrome as well as in developing therapeutic modalities for these conditions. In this connection, we contributed to generating scientific evidence that constitutes a basis for the development of anti妖iabetic therapies targeted at the regulation of insulin and/or adiponectin action as well as to the discovery of candidate anti-diabetic compounds, by elucidating the mechanisms involved in the inter-organ cross-walks in the regulation of insulin and/or adiponectin action.

Assessment Rating

Verification Result (Rating)

A+

Research Products

• [Journal Article] Isoform-independent and -dependent phosphorylation of microtubule-associated protein tau in mouse brain during postnatal development. (2017)
  • Author(s): K. Yamano, M. Kuroyanagi-Hasegawa, M. Esaki, M. Yokota, and T. Endo
  • Journal Title: The Journal of Biological Chemistry Volume: 283 Pages: 10084-10096
  • DOI: 10.1074/jbc
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Adiponectin receptor as a key player in healthy longevity and obesity-related diseases. (2013)
  • Author(s): Yamauchi T, Kadowaki T.
  • Journal Title: Cell Metab. Volume: 17 Pages: 185-196
  • DOI: 10.1016/j.cmet.2013.01.001
  • Peer Reviewed
• [Journal Article] Baseline predictive factors for glycemic control in Japanese type 2 diabetes patients treated with insulin glargine plus oral antidiabetic drugs: ALOHA study subanalysis (2013)
  • Author(s): Kadowaki T, Ohtani T, Odawara M.
  • Journal Title: Diabetol Int Volume: 4 Pages: 16-22
  • NAID: 10030925706
• [Journal Article] Efficacy, safety and dose-response relationship of teneligliptin, a dipeptidyl peptidase-4 inhibitor, in Japanese patients with type 2 diabetes mellitus. (2013)
  • Author(s): Kadowaki T, Kondo K.
  • Journal Title: Diabetes Obes. Metab. Volume: -
  • DOI: 10.1111/dom.12092
  • Peer Reviewed
• [Journal Article] Genome-wide association study identifies a novel locus contributing to type 2 (2013)
  • Author(s): Saxena R, Yamauchi T, Hara K Saxena R, Yamauchi T, Hara K DIAGRAM MuTHER; TGEN, Kadowaki T
  • Journal Title: Diabetes Volume: 62 Pages: 1746-1755
  • DOI: 10.2337/db12-1077
  • Peer Reviewed
• [Journal Article] Baseline predictive factors for glycemic control in Japanese type 2 diabetes patients treated with insulin glargine plus oral antidiabetic drugs: ALOHA study subanalysis. (2013)
  • Author(s): Kadowaki T, Ohtani T, Odawara M
  • Journal Title: Diabetol Int. Volume: 4 Pages: 16-22
  • NAID: 10030925706
  • Peer Reviewed
• [Journal Article] Genome-wide association study in a Chinese population identifies a susceptibility locus for type 2 diabetes at 7q32 near PAX4 (2013)
  • Author(s): Ma R. C. W., Hu C., Tam C. H.,..., Hara K.,..., Yamauchi T.,..., Kadowaki T., Tai E. S., Zeggini E., McCarthy M. I., Hon K. L., Baum L., Tomlinson B., So W. Y., Bao Y., Chan J. C. N., Jia W
  • Journal Title: Diabetologia Volume: -
  • Peer Reviewed
• [Journal Article] Diabetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium, Nakamura Y, Kadowaki T: A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations (2012)
  • Author(s): Imamura M,1,Yamauchi T, Hara K, Okada-Iwabu M, Iwabu M
  • Journal Title: Human Molecular Genatics Volume: 21 Pages: 3042-3049
• [Journal Article] Expression-based genome-wide association study links CD44 in adipose tissue with type 2 diabetes. (2012)
  • Author(s): Kodama K, Hara K, Kadowaki T, Butte AJ
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 109 Pages: 7049-7054
  • DOI: 10.1073/pnas.1114513109
  • Peer Reviewed
• [Journal Article] Cntrol of beta cell function and proliferation in mice stimulated by small-molecule glucokinase activator under various conditions (2012)
  • Author(s): Nakamura A, Kubota N, Kadowaki T
  • Journal Title: Diabatologia Volume: 55 Pages: 1745-1754
• [Journal Article] Saturated fatty acid and TLR signaling link (3 cell dysfunction and islet inflammation (2012)
  • Author(s): Eguchi K, Kadowaki T
  • Journal Title: Cell Metal Volume: 15 Pages: 518-533
• [Journal Article] Genetic risk score constructed using 14 susceptibility alleles for type 2 diabetes is associated with the early onset of diabetes and may predict the future requirement of insulin injections among japanese individuals. (2012)
  • Author(s): Iwata M, Hara K, Kadowaki T
  • Journal Title: Diabetes Care Volume: 35 Pages: 1763-1770
  • DOI: 10.2337/dc11-2006
  • Peer Reviewed
• [Journal Article] Potential Formula for the Calculation of Starting and Incremental Insulin Glargine Doses: ALOHA Subanalysis (2012)
  • Author(s): Kadowaki T, Ohtani T, Odawara M
  • Journal Title: PLoSOne Volume: 7
  • DOI: 10.1371/journal.pone.0041353
• [Journal Article] In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokineand integrin signaling (2012)
  • Author(s): S.Nishimura
  • Journal Title: Blood. Volume: 119 Pages: 128-131
  • DOI: 10.1182/blood-2011-09-381400
  • Peer Reviewed
• [Journal Article] Depletion of homeodomain-interacting protein kinase 3 impairs insulin secretion and glucose tolerance in mice. (2012)
  • Author(s): Shojima N, Hara K, Kubota N, Yamauchi T, Ueki K, Kadowaki T
  • Journal Title: Diabetologia Volume: 55 Pages: 3318-3330
  • DOI: 10.1007/s00125-012-2711-1
  • Peer Reviewed
• [Journal Article] Erectile dysfunction and cardiovascular events in diabetic men: a meta-analysis of observational studies. (2012)
  • Author(s): Yamada T, Hara K, Umematsu H, Suzuki R, Kadowaki T.
  • Journal Title: PLoS One Volume: 7
  • DOI: 10.1371/journal.pone.0043673
  • Peer Reviewed
• [Journal Article] Fujita H, Hara K, Shojima N, Horikoshi M, Iwata M, Hirota Y, Tobe K, Seino S, Kadowaki T (2012)
  • Author(s): Fujita H, Hara K, Kadowaki T
  • Journal Title: J. Hum. Genet. Volume: 57 Pages: 776-779
  • DOI: 10.1038/jhg.2012.110
  • Peer Reviewed
• [Journal Article] Snap Shot: Insulin Signaling Pathways (2012)
  • Author(s): Kadowaki T, Ueki K, Yamauchi T, Kubota N.
  • Journal Title: Cep Volume: 148 Pages: 624-624
• [Journal Article] SnapShot: Physiology of Insulin Signaling (2012)
  • Author(s): Kadowaki T, Kubota N, Ueki K, Yamauchi T
  • Journal Title: Ce11 Volume: 148 Pages: 834-834
• [Journal Article] Nio Y, Yamauchi T, Iwabu M, Okada-Iwabu M, Funata M, Yamaguchi M, Ueki K, Kadowaki T. (2012)
  • Author(s): Nio Y, Yamauchi T, Iwabu M, Okada-Iwabu M, Ueki K, Kadowaki T
  • Journal Title: Diabetologia Volume: 55 Pages: 3350-3358
  • DOI: 10.1007/s00125-012-2710-2
  • Peer Reviewed
• [Journal Article] Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. (2012)
  • Author(s): Cho YS, Yamauchi T, Hara K, Kadowaki T
  • Journal Title: Nature Genetics Volume: 44 Pages: 67-72
  • DOI: 10.1038/ng.1019
  • Peer Reviewed
• [Journal Article] Diabetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium, Nakamura Y and Kadowaki T. A single nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations (2012)
  • Author(s): Imamura M, Maeda S, Yamauchi T, Hara K, Yasuda K,..., Okada-Iwabu M, Iwabu M, Shojima N,..., Nakamura Y, Kadowaki T
  • Journal Title: Hum Mol Genet. Volume: 21 Pages: 3042-2049
  • DOI: 10.1093/hmg/dds113
  • Peer Reviewed
• [Journal Article] Control of beta cell function and proliferation in mice stimulated by small molecule glucokinase activator under various conditions (2012)
  • Author(s): Nakamura A, Togashi Y, Orime K, Sato K, Shirakawa J, Ohsugi M, Kubota N, Kadowaki T, Terauchi Y
  • Journal Title: Diabetologia Volume: (In press) Pages: 1745-1754
  • DOI: 10.1007/s00125-012-2521-5
  • Peer Reviewed
• [Journal Article] Saturated Fatty Acid and TLR Signaling Link β Cell Dysfunction and Islet Inflammation. (2012)
  • Author(s): Eguchi K, Manabe I, Oishi-Tanaka Y, Ohsugi M, Kono N, Ogata F, Yagi N, Ohto U, Kimoto M, Miyake K, Tobe K, Arai H, Kadowaki T, Nagai R
  • Journal Title: Cell Metab Volume: 15 Pages: 1-16
  • DOI: 10.1016/j.cmet.2012.01.023
  • Peer Reviewed
• [Journal Article] Potential Formula for the Calculation of Starting and Incremental Insulin Glargine Doses: ALOHA Subanalysis. (2012)
  • Author(s): Kadowaki T, Ohtani T, Odawara M
  • Journal Title: PLoS One Volume: 7
  • DOI: 10.1371/journal.pone.0041358
  • Peer Reviewed
• [Journal Article] Association of adenovirus 36 infection with obesity and metabolic markers in humans: a meta-analysis of observational studies. (2012)
  • Author(s): Yamada T, Hara K, Kadowaki T
  • Journal Title: PLoS One Volume: 7
  • DOI: 10.1371/journal.pone.0042031
  • Peer Reviewed
• [Journal Article] SnapShot : Physiology of Insulin Signaling (2012)
  • Author(s): Kadowaki T, Kubota N, Ueki K, Yamauchi T
  • Journal Title: Cell Volume: 148 Pages: 834-834
  • DOI: 10.1016/j.cell.2012.02.004
  • Peer Reviewed
• [Journal Article] SnapShot : Insulin Signaling Pathways (2012)
  • Author(s): Kadowaki T, Ueki K, Yamauchi T, Kubota N
  • Journal Title: Cell Volume: 148 Pages: 624-624
  • DOI: 10.1016/j.cell.2012.01.034
  • Peer Reviewed
• [Journal Article] Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle (2011)
  • Author(s): Kubota T, Kubota N, Ueki K, Kadowaki T
  • Journal Title: Cell Metabolism Volume: 13 Pages: 294-307
• [Journal Article] Adiponectin enhances insulin sensitivity by increasing hepatic IRS-2 expression via a macrophage-derived IL-6-dependent pathway (2011)
  • Author(s): Awazawa M, Ueki K, Yamauchi T, Kubota, Kadowaki T
  • Journal Title: Cell Metab Volume: 13 Pages: 401-412
  • DOI: 10.1016/j.cmet.2011.02.010
  • Peer Reviewed
• [Journal Article] Global mapping of cell type-specific open chromatin by FAIRE seq reveals the regulatory role of the NFI family in adipocyte differentiation (2011)
  • Author(s): Waki H, Yamauchi T, Iwabu M, Okada-Iwabu M, Ueki K, Kadowaki T
  • Journal Title: PLoS Genetics Volume: 7
• [Journal Article] Blockade of class lB phosphor inositide-3 kinase ameliorates obesity induced inflammation and insulin resistance (2011)
  • Author(s): Kobayashi N, Ueki, Kubota N, Hara K, Kadowaki T
  • Journal Title: Proc. Nat/. Acad. Sci. U.S.A. Volume: 108 Pages: 5753-5758
• [Journal Article] Crystal structure of the CA2+/calmodulin-dependent protein kinase kinase in complex with the inhibitor STO-609 (2011)
  • Author(s): Kukimoto-Nino M, Yamauchi T, Okada Iwabu M, Iwabu M, Kadowaki T
  • Journal Title: J. Biol. Chem Volume: 286 Pages: 22570-22579
  • DOI: 10.1074/jbc.m111.251710
  • Peer Reviewed
• [Journal Article] The other sweet face of XBP-1 (2011)
  • Author(s): Ueki K, Kadowaki T
  • Journal Title: Nature Medicine Volume: 17 Pages: 246-248
  • DOI: 10.1038/nm0311-246
• [Journal Article] Adiponectin receptor signaling: a new layer to the current model (2011)
  • Author(s): Kadowaki T, Yamauchi T
  • Journal Title: Cell Metabolism Volume: 13 Pages: 123-124
  • DOI: 10.1016/j.cmet.2011.01.012
• [Journal Article] Thiazolidinediones enhance sodium- coupled bicarbonate absorption from renal proximal tubules via PPAR γ -dependent nongenomic signaling (2011)
  • Author(s): Endo Y, Yamauchi T, Kubota N, Kadowaki T
  • Journal Title: Cell Metabolism Volume: 13 Pages: 550-561
  • DOI: 10.1016/j.cmet.2011.02.015
  • Peer Reviewed
• [Journal Article] Apoptosis inhibitor of macrophage (AIM) is required for obesity-associated recruitment of inflamma- tory macrophages into adipose tissue (2011)
  • Author(s): Jun Kurokawa, et al
  • Journal Title: Proc. Natl. Acad. Sci. U.S.A Volume: vol.108 Pages: 12072-12077
  • DOI: 10.1073/pnas.1101841108
  • Peer Reviewed
• [Journal Article] Loss of adiponectin promotes intestinal carcinogenesis in Min and wild-type mice (2011)
  • Author(s): Mutoh M, Kubota N, Kadowaki T
  • Journal Title: Gastroenterology Volume: 140 Pages: 2000-2008
  • DOI: 10.1053/j.gastro.2011.02.019
• [Journal Article] The diabetogenic VPS13C/C2CD4A/C2CD4B rs7172432 variant impairs glucose-stimulated insulin response in 5,722 non-diabetic Danish individuals (2011)
  • Author(s): Grarup N, Yamauchi T, Hara K, Kadowaki T
  • Journal Title: Diabetologia Volume: 54 Pages: 789-794
  • DOI: 10.1007/s00125-010-2031-2
• [Journal Article] Global mapping of cell type-specific open chromatin by FAIRE-seq reveals the regulatory role of the NFI family in adipocyte differentiation (2011)
  • Author(s): Waki H, Nakamura M, Yamauchi T,Wakabayashi K, Yu J, Hirose-Yotsuya L,Take K, Sun W, Iwabu M, Okada-Iwabu M,Fujita T, Aoyama T, Tsutsumi S, Ueki K,Kodama T, Sakai J, Aburatani H, Kadowaki T
  • Journal Title: PLoS genetics Volume: 7(10)
  • DOI: 10.1371/journal.pgen.1002311
  • Peer Reviewed
• [Journal Article] Evi1 is essential for hematopoietic stem cell self-renewal and its expression marks hematopoietic cells with long-term multilineage repopulating activity (2011)
  • Author(s): Keisuke Kataoka
  • Journal Title: J Exp Med Volume: 208 Pages: 2403-16
  • DOI: 10.1084/jem.20110447
  • Peer Reviewed
• [Journal Article] Metabolomic analysis reveals hepatic metabolite perturbations in citrin/mitochondrial glycerol-3-phosphate dehydrogenase double-knockout mice, a model of human citrin deficiency (2011)
  • Author(s): Saheki T, Inoue K, Ono H, Tushima A, Katsura N, Yokogawa M, Yoshidumi Y, Kuhara T, Ohse M, Eto K, Kadowaki T, Sinasac DS, Kobayashi K
  • Journal Title: Mol Genet Metab Volume: 104 Pages: 492-500
  • DOI: 10.1016/j.ymgme.2011.08.015
  • Peer Reviewed
• [Journal Article] Possibility of increasing cholesterol efflux by adiponectin and its receptors through the ATP binding cassette transporter A1 in HEK293T cells (2011)
  • Author(s): Kitajima, K,Miura S, Yamauchi T, Uehara Y, Kiya Y, Rye KA, Kadowaki T, Saku K
  • Journal Title: Biochem.Biophys.Res.Commun. Volume: 411 Pages: 305-311
  • DOI: 10.1016/j.bbrc.2011.06.131
  • Peer Reviewed
• [Journal Article] Blockade of class IB phosphoinositide-3 kinase ameliorates obesity-induced inflammation and insulin resistance (2011)
  • Author(s): Kobayashi N, Ueki K, Okazaki Y, Iwane A, Kubota N, Ohsugi M, Awazawa M, Kobayashi M, Sasako T, Kaneko K, Suzuki M, Nishikawa Y, Hara K, Yoshimura K, Koshima I, Goyama s, Murakami K, Sasaki J, Nagai R, Kurokawa M, Sasaki T, Kadowaki T
  • Journal Title: Proc Natl Acad Sci USA Volume: 108 Pages: 5753-5758
  • DOI: 10.1073/pnas.1016430108
  • Peer Reviewed
• [Journal Article] Thiazolidinediones Enhance Sodium-Coupled Bicarbonate Absorption from Renal Proximal Tubules via PPARγ-Dependent Nongenomic Signaling (2011)
  • Author(s): Endo Y, Suzuki M, Yamada H, Horita s, Kunimi M, Yamazaki O, Shirai A, Nakamura M, Iso-O N, Li Y, Hara M, Tsukamoto K, Moriyama N, Kudo A, Kawakami H, Yamauchi T, Kubota N, Kadowaki T, Kume H, Enomoto Y, Homma Y, Seki G, Fujita T
  • Journal Title: Cell Metabolism Volume: 13 Pages: 550-561
  • Peer Reviewed
• [Journal Article] Adiponectin enhances insulin sensitivity by increasing hepatic IRS-2 expression via macrophage-derived IL-6 dependent pathway. (2011)
  • Author(s): Awazawa M, Ueki K, Inabe K, Yamauchi T, Kubota N, Kaneko K, Kobayashi M, Iwane A, Sasako T, Ohsugi M, Takamoto I, Yamashita S, Asahara H, Akira S, Kasuga M, Kadowaki T
  • Journal Title: Cell Metabolism 13 Pages: 401-412
• [Journal Article] Impaired insulin signaling in the endothelial cells reduces insulin-induced glucose uptake by the skeletal muscle. (2011)
  • Author(s): Kubota T, Kubota N, Kumagai H, Yamaguchi S, Kozono H, Takahashi T, Inoue M, Itoh S, Takamoto I, Sasako T, Kumagai K, Kawai T, Hashimoto S, Kobayashi T, Sato M, Tokuyama K, Nishimura S, Tsunoda M, Ide T, Murakami K, Yamazaki T, Ezaki O, Kawamura K, Masuda H, Moroi M, Sugi K, Oike Y, Shimokawa H, Yanagihara N, Tsutsui M, Terauchi Y, Tobe K, Nagai R, Kamata K, Inoue K, Kodama T, Ueki K, Kadowaki T
  • Journal Title: Cell Metabolism 13 Pages: 294-307
• [Journal Article] The other sweet face of XBP-1. (2011)
  • Author(s): Ueki K, Kadowaki T.
  • Journal Title: Nature Med. Volume: 17 Pages: 246-248
  • Peer Reviewed
• [Journal Article] Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle. (2011)
  • Author(s): Kubota T, Kubota N, Kumagai H, Yamaguchi S, Kozono H, Takahashi T, Inoue M, Itch S, Takamoto I, Sasako T, Kumagai K, Kawai T, Hashimoto S, Kobayashi T, Sato M, Tokuyama K, Nishimura S, Tsunoda M, Ide T, Murakami K, Yamazaki T, Ezaki 0, Kawamura K, Masuda H, Moroi M, Sugi K, Oike Y, Shimokawa H, Yanagihara N, TsutsuiM, Terauchi Y, Tobe K, Nagai R, Kamata K, Inoue K, Kodama T, Ueki K, Kadowaki T.
  • Journal Title: Cell Metab. Volume: 13 Pages: 294-307
  • Peer Reviewed
• [Journal Article] Adiponectin receptor signaling : a new layer to the current model. (2011)
  • Author(s): Kadowaki T, Yamauchi T.
  • Journal Title: Cell Metab. Volume: 13 Pages: 123-124
  • Peer Reviewed
• [Journal Article] Adiponectin and AdipoR1 regulate PGC-1・and mitochondria by Ca^<2+> and AMPK/SIRT1 (2010)
  • Author(s): Iwabu, M., Yamauchi, T., Okada-Iwabu, M., Sato, K., Nakagawa, T., Funata, M., Yamaguchi, M., Namiki, S., Nakayama, R., Tabata, M., Ogata, H., Kubota, N.,Takamoto, I., Hayashi, YK., Yamauchi, N., Waki, H., Fukayama, M., Nishino, I., Tokuyama, K., Ueki, K., Oike, Y., Ishii, S., Hirose, K., Shimizu, T., Touhara, K., and Kadowaki, T
  • Journal Title: Nature Volume: 464 Pages: 1313-1319
  • DOI: 10.1038/nature08991
  • Peer Reviewed
• [Journal Article] genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B (2010)
  • Author(s): Yamauchi T, Ham K, Iwabu M, Okada-Iwabu M, Kadowaki T
  • Journal Title: Nature Genetics Volume: 42 Pages: 864-868
  • DOI: 10.1038/ng.660
• [Journal Article] Class IA phosphatidylinositol 3-kinase in pancreatic beta cells controls insulin secretion by multiple mechanisms (2010)
  • Author(s): Kaneko K, Ueki K, Kadowaki T
  • Journal Title: Cell Metabolism Volume: 12 Pages: 619-632
  • DOI: 10.1016/j.cmet.2010.11.005
• [Journal Article] Dietary restriction; Standing up for sirtuins (2010)
  • Author(s): Baur JA, Kadowaki T
  • Journal Title: Science Volume: 329 Pages: 1012-1015
  • DOI: 10.1126/science.329.5995.1012
• [Journal Article] Macrophage-derived AIM is endocytosed into adipocytes and decreases lipid droplets via inhibition of fattty acid synthase activity (2010)
  • Author(s): Kurokawa J, Kubota N, Kadowaki T
  • Journal Title: Cell Metabolism Volume: 11 Pages: 479-492
  • DOI: 10.1016/j.cmet.2010.04.013
• [Journal Article] A liver-derived secretory protein, selenoprotein P, causes insulin resistance (2010)
  • Author(s): Misu H, Kubota N, Kadowaki T
  • Journal Title: Cell Metabolis Volume: 12 Pages: 483-495
  • NAID: 120002661942
• [Journal Article] Long-term pancreas allograft survival in simultaneous pancreas-kidney transplantation by era: UN OS registry analysis (2010)
  • Author(s): Waki K, Terasaki PI, Kadowaki T
  • Journal Title: Diabetes Care Volume: 33 Pages: 1789-1791
  • DOI: 10.2337/dc09-2276
• [Journal Article] Identification of KCNJ15 as a susceptibility gene in Asian patients with type 2 diabetes mellitus (2010)
  • Author(s): Okamoto K,, Kadowaki T
  • Journal Title: Am.J.Hum. Genet Volume: 86 Pages: 54-64
  • DOI: 10.1016/j.ajhg.2009.12.009
• [Journal Article] Regulatory polymorphism in transcription factor KLF5 at the MEF2 element alters the response to angiotensin 11 and is associated with human hypertension (2010)
  • Author(s): Oishi Y, Hara K, Kadowaki T
  • Journal Title: FASBB J Volume: 24 Pages: 1780-1788
  • DOI: 10.1096/fj.09-146589
• [Journal Article] The critical role of neutral cholesterol ester hydrolase 1 in cholesterol removal from human macrophages. (2010)
  • Author(s): Igarashi M, Kadowaki T
  • Journal Title: Circ Res. Volume: 107 Pages: 1387-1395
  • DOI: 10.1161/circresaha.110.226613
• [Journal Article] Polyunsaturated fatty acids selectively suppress sterol regulatory element-binding protein-1 through proteolytic processing and autoloop regulatory circuit (2010)
  • Author(s): Takeuchi Y, Kadowaki T
  • Journal Title: J. Biol. Chem. Volume: 285 Pages: 11681-11691
• [Journal Article] Class IA phosphatidylinositol 3-kinase in pancreatic b cells controls insulin secretion by multiple mechanisms. (2010)
  • Author(s): Kaneko K, Ueki K, Takahashi N, Hashimoto S, Okamoto M, Awazawa M, Okazaki Y, Ohsugi M, Inabe K, Umehara T, Yoshida M, Kakei M, Kitamura T, Luo J, Kulkami RN, Kahn CR, Kasai H, Cantley LC, Kadowaki T
  • Journal Title: Cell Metabolism 12 Pages: 619-632
• [Journal Article] Adiponectin and AdipoR1 regulate PGC1・and mitochondria by Ca^<2+> and AMPK/SIRT1. (2010)
  • Author(s): Iwabu M, Yamauchi T, Okada-Iwabu M, Sato K, Nakagawa T, Funata M, Yamaguchi M, Namiki S, Nakayama R, Tabata M, Ogata H, Kubota N, Takamoto I, Hayashi YK, Yamauchi N, Waki H, Fukayama M, Nishino I, Tokuyama K, Ueki K, Oike Y, Ishii S, Hirose K, Shimizu T, Touhara K, Kadowaki T
  • Journal Title: Nature 464 Pages: 1313-1319
• [Journal Article] A liver-derived secretory protein, selenoprotein P, causes insulin resistance. (2010)
  • Author(s): Misu H, Takamura T, Takayama H, Hayashi H, Matsuzawa-Nagata N, Kurita S, Ishikura K, Ando H, Takeshita Y, Ota T, Sakurai M, Yamashita T, Mizukoshi E, Yamashita T, Honda M, Miyamoto K, Kubota T, Kubota N, Kadowaki T, Kim HJ, Lee IK, Minokoshi Y, Saito Y, Takahashi K, Yamada Y, Takakura N, Kaneko S.
  • Journal Title: Cell Metab. Volume: 12 Pages: 483-4951
  • NAID: 120002661942
  • Peer Reviewed
• [Journal Article] Class IA phosphatidylinositol 3-kinase in pancreatic b cells controls insulin secretion by multiple mechanisms. (2010)
  • Author(s): Kaneko K, Ueki K, Takahashi N, Hashimoto S, Okamoto M, Awazawa M, Okazaki Y, Ohsugi M, Inabe K, Umehara T, Yoshida M, Kakei M, Kitamura T, Luo J, Kulkami RN, Kahn CR, Kasai H, Cantley LC, Kadowaki T
  • Journal Title: Cell Metab. Volume: 12 Pages: 619-632
  • Peer Reviewed
• [Journal Article] A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBEZE2 and C2CD4A-C2CD4B. (2010)
  • Author(s): Yamauchi T, Hara K, Maeda S, Yasuda K, Takahashi A, Horikoshi M, Nakamura M, Fujito H, Grarup N, Cauchi S, Ng DPK, Ma RCW, Tsunoda T, Kubo M, Watada H, Maegawa H, Okada-lwabu M, Iwabu M, Shojima N, Shin HD, Andersen G, Witte DR, Jorgensen T, Lauritzen T, Sandbak A, Hansen T, Ohshige T, Omori S, Saito I, Kaku K, Hirose H, So WY, Beury D, Chan JCN, Park KS, Tai ES, Ito C, Tanaka Y, Kashiwag A, Kawamori R, Kasuga M, Frogue P, Pedersen O, Kamatani N, Nakamura Y, Kadowaki T
  • Journal Title: Nature Genetics Volume: 42 Pages: 864-868
  • Peer Reviewed
• [Journal Article] Dietary restriction; Standing up for sirtuins. (2010)
  • Author(s): Helfand, Imai S, Itoh H, Kadowaki T, Koya D, Leeuwenburgh C, Mcburney M, Nabeshima Y, Neri C, Oberdoerffer P, PestellRG, Rogina B, Sadoshima J, Sartorelli V, Serrano M, Sinclair DA, Steegborn C, Tatar M, Tissenbaum HA, Tong Q, Tsubota K, Vaquero A, Verdin E
  • Journal Title: Science Volume: 329 Pages: 1012-1015
  • Peer Reviewed
• [Journal Article] Macrophage-derived AIM is endocytosed into adipocytes and decreases lipid droplets via inhibition of fattty acid synthase activity. (2010)
  • Author(s): Kurokawa J, Arai S, Nakashima K, Nagano H, Nishijima A, Miyata K, Ose R, Mori M, Kubota N, Kadowaki T, Oike Y, Koga H, Febbraio M, Iwanaga T, Miyazaki T
  • Journal Title: Cell Metab. Volume: 11 Pages: 479-492
  • Peer Reviewed
• [Journal Article] Adiponectin and AdipoRl regulate PGCI and mitochondria by Ca^<2+> and AMPK/SIRTI. (2010)
  • Author(s): Iwabu M, Yamauchi T, Okada-lwabu M, Sato K, Nakagawa T, Funata M, Pamaguchi M, Namiki S, Nakayama R, Tabata M, Ogata H, .Kubota N, Takamoto I, Hayashi YK, Yamauchi N, Waki H, Fukayama M, Nishino I, Tokuyama K, Ueki K, Oike Y, Ishii S, Hirose K, Shimizu T, Touhara K, Kadowaki T
  • Journal Title: Nature Volume: 464 Pages: 1313-1319
  • Peer Reviewed
• [Journal Article] Polyunsaturated fatty acids selectively suppress sterol regulatoryelement-binding protein-1 through proteolytic processing and autoloop regulatory circuit. (2010)
  • Author(s): Takeuchi Y, Yahagi N, Izumida Y, Nishi M, Kubota M, Teraoka Y, Yamamoto T, Matsuzaka T, Nakagawa Y, Sekiya M, Iizuka Y, Ohashi K, Osuga J, Gotoda T, Ishibashi S, Itaka K, Kataoka K, Nagai R, Yamada N, Kadowaki T, Shimano H
  • Journal Title: J.Biol.Chem. Volume: 285 Pages: 11681-11691
  • Peer Reviewed
• [Journal Article] Adiponectin recceptors are downregulated in human gastric cancer. (2010)
  • Author(s): Otani K, Kitayama J, Kamei T, Soma D, Miyato H, Yamauchi T, Kadowaki T, Nagawa H
  • Journal Title: J Gastroenterol. Volume: 45 Pages: 918-927
  • Peer Reviewed
• [Journal Article] Adiponectin and AdipoR1 regulate PGC-lalpha and mitochondria by Ca(2+) and AMPK/SIRT1. (2010)
  • Author(s): Iwabu M, Yamauchi T, Okada-Iwabu M, Sato K, Nakagawa T, Funata M, Yamaguchi M, Namiki S, Nakayama R, Tabata M, Ogata H, Kubota N, Takamoto I, Hayashi YK, Yamauchi N, waki H, Fukayama M, Nishino I, Tokuyama K, Ueki K, Oike Y, Ishii S, Hirose K, Shimizu T, Touhara K, Kadowaki T.
  • Journal Title: Nature (published online Mar.31, 2010)
  • Peer Reviewed
• [Journal Article] Decreased insulin secretion and accumulation of triglyceride in beta cells overexpressing a dominant-negative form of AMP-activated protein kinase. (2010)
  • Author(s): Okazaki Y, Eto K, Yamashita T, Okamoto M, Ohsugi M, Noda M, Terauchi Y, Ueki K, Kadowaki T
  • Journal Title: Endocr J 57 Pages: 141-52
  • NAID: 130004443612
  • Peer Reviewed
• [Journal Article] Regulatory polymorphism in transcription factor KLF5 at the MEF2 element alters the response to angiotensin II and is associaed with human hypertension. (2010)
  • Author(s): Oishi Y, Manabe I, Imai Y, Hara K, Horikoshi M, Fujiu K, Tanaka T, Aizawa T, Kadowaki T, Nagai R
  • Journal Title: FASEB J (published online Jan.26, 2010)
  • Peer Reviewed
• [Journal Article] Identification of KCNJ15 as a susceptibility gene in Asian patients with type 2 diabetes mellitus. (2010)
  • Author(s): Okamoto K, Iwasaki N, Nishimura C, Doi K, Noiri E, Nakamura S, Tanizawa M, Ogata M, Fujimaki R, Grarup N, Pisinger C, Borch-Johnsen K, Lauritzen T, Sandbaek A, Hansen T, Yasuda K, Osawa H, Nanjo K, Kadowaki T, Kasuga M, Pedersen O, Fujita T, Kamatani N, Iwamoto Y, Tokunaga K
  • Journal Title: Am J Hum Genet 86 Pages: 54-64
  • Peer Reviewed
• [Journal Article] Colestilan monotherapy significantly improves glycaemic control and LDL cholesterol levels in patients with type 2 diabetes : a randomized double-blind placebo-controlled study. (2010)
  • Author(s): Kondo K, Kadowaki T
  • Journal Title: Diabetes Obes Metab 12 Pages: 246-251
  • Peer Reviewed
• [Journal Article] Peroxisome proliferator-activated receptor gamma agonist rosiglitazone increases the expression of very low density lipoprotein receptor gene in adipocytes (2009)
  • Author(s): Takazawa T, Yamauchi T, Iwabu M, Okada-Iwabu M, Ueki K, Kadowaki T
  • Journal Title: J. Biol. Chem. Volume: 284 Pages: 30049-30057
• [Journal Article] CD8+effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity (2009)
  • Author(s): Nishimura S, Hara K, Ueki K, Kadowaki T
  • Journal Title: Nat Med Volume: 15 Pages: 914-920
  • DOI: 10.1038/nm.1964
  • Peer Reviewed
• [Journal Article] Ablation of neutral cholester olester hydrolase 1 accelerates atherosclerosis (2009)
  • Author(s): Sekiya M, Kadowaki T
  • Journal Title: Cell Metab Volume: 10 Pages: 219-228
  • DOI: 10.1016/j.cmet.2009.08.004
• [Journal Article] Diabetes n Asia: epidemiology, risk factors, and pathophysiology (2009)
  • Author(s): Chan JC, Kadowaki T
  • Journal Title: JAMA Volume: 301 Pages: 2129-2140
  • DOI: 10.1001/jama.2009.726
• [Journal Article] Critical role of class IA P13K for c-Rel expression in B lymphocytes (2009)
  • Author(s): Matsuda S, Kadowaki T
  • Journal Title: Blood Volume: 113 Pages: 1037-1044
  • DOI: 10.1182/blood-2008-06-163725
• [Journal Article] Neuronal IGF-1 resistance reduces Ab-accumulation and protects against premature death in a model of Alzheimer's disease (2009)
  • Author(s): Freude S, Kubota N, Kadowaki T
  • Journal Title: FASEB J. Volume: 23 Pages: 3315-3324
  • DOI: 10.1096/fj.09-132043
• [Journal Article] Replication study for the association of new meta-analysis-derived risk loci with sus- ceptibility to type 2 diabetes in 6,244 Japanese individuals (2009)
  • Author(s): Omori S, Kadowaki T
  • Journal Title: Diabetologia Volume: 52 Pages: 1554-1560
  • DOI: 10.1007/s00125-009-1397-5
• [Journal Article] Glucose effects on beta-cell growth and survival require activation of insulin receptors and insulin receptor substrate 2 (2009)
  • Author(s): Assmann A, Kadowaki T
  • Journal Title: Mol. Cell. Bio1. Volume: 29 Pages: 3219-3228
• [Journal Article] The death effector domain-containing DEDD supports S6K1 activity via preventing Cdk1- dependent inhibitory phosphor- rylation (2009)
  • Author(s): Kurabe N, Kubota N, Kadowaki T
  • Journal Title: J. Biol. Chem. Volume: 284 Pages: 5050-5055
• [Journal Article] Impact of small molecule glucokinase activator on glucose metabolism, and beta cell function and mass (2009)
  • Author(s): Nakamura A, Kubota N, Kadowaki T
  • Journal Title: Endocrinology Volume: 150 Pages: 1147-1154
• [Journal Article] Targeting of neutral cholesterol ester hydrolase to the endoplasmic reticulum via its N-terminal sequence (2009)
  • Author(s): Igarashi M, Kadowaki T
  • Journal Title: J. Lipid Res Volume: 51 Pages: 274-285
  • DOI: 10.1194/jlr
• [Journal Article] Role of the liver in glucose homeostasis in P13-kinase p85{alpha}-deficient mice (2009)
  • Author(s): Aoki K, Kubota N, Kadowaki T
  • Journal Title: Am. J. Physiol. Endocrinol. Metab Volume: 296
  • DOI: 10.1152/ajpendo.90528.2008
• [Journal Article] Alpha2-AMPK activity is not essential for an increase in fatty acid oxi- dation during low-intensity exercise (2009)
  • Author(s): Miura S, Kubota N, Kadowaki T, Ezaki O, et al.
  • Journal Title: Am. J. Physiol. Endocrinol. Metab. Volume: 296
  • DOI: 10.1152/ajpendo.90690.2008
• [Journal Article] How controlling of hypertension might matter-Beyond blood pressure- (2009)
  • Author(s): Hara K, Kadowaki T
  • Journal Title: Circulation J 73 Pages: 2208-2209
  • Peer Reviewed
• [Journal Article] Peroxisome proliferator-activated receptor gamma agonist rosiglitazone increases the expression of very low density lipoprotein receptor gene in adipocytes. (2009)
  • Author(s): Takazawa T, Yamauchi T, Tsuchida A, Takata M, Hada Y, Iwabu M, Okada-Iwabu M, Ueki K, Kadowaki T
  • Journal Title: J Biol Chem 30 Pages: 30049-30057
  • Peer Reviewed
• [Journal Article] CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. (2009)
  • Author(s): Nishimura S, Manabe I, Nagasaki M, Eto K, Yamashita H, Ohsugi M, Otsu M, Hara K, Ueki K, Sugiura S, Yoshimura K, Kadowaki T, Nagai R
  • Journal Title: Nat Med 15 Pages: 914-920
  • Peer Reviewed
• [Journal Article] Reconsideration of insulin signals induced by improved laboratory animal diets, Japanese and American diets, in IRS-2 deficcient mice. (2009)
  • Author(s): Hashimoto H, Arai T, Mori A, Kawai K, Hikishima K, Ohnishi Y, Eto T, Ito M, Hioki K, Suzuki R, Ohsugi M, Saito M, Ueyama Y, Okano H, Yamauchi T, Kubota N, Ueki K, Tobe K, Tamaoki N, Kadowaki T, Kosaka K
  • Journal Title: Exp Clin Endocrinol Diabetes 117 Pages: 577-86
  • Peer Reviewed
• [Journal Article] Efficacy and safety of insulin glulisine in Japanese patients with type l diadbetes mellitus. (2009)
  • Author(s): Kawamori R, Kadowaki T, Ishii H, Iwasaki M, Iwamoto Y
  • Journal Title: Diabetes Obes Metab 11 Pages: 891-899
  • Peer Reviewed
• [Journal Article] Effects of insulin glulisine sa mono- or add-on therapy in patients with type 2 diabetes mellitus. (2009)
  • Author(s): Kawamori R, Iwamoto Y, Kadowaki T, Iwasaki M, Kim SW, Woo JT, Baik SH, Yoon KH
  • Journal Title: Diabetes Obes Metab 11 Pages: 900-909
  • Peer Reviewed
• [Journal Article] Successful desensitization by glargine administration in patient with insulin allergy : a case report. (2009)
  • Author(s): Hara M, Izumida Y, Sato N, Ohashi K, Osuga JI, Tobe K, Tsukamoto K, Kadowaki T
  • Journal Title: Diabetes Res Clin Pract 84 Pages: 48-49
  • Peer Reviewed
• [Journal Article] Adiponectin suppresses hepatic SREBP1c expression in an AdipoR1/LKB1/AMPK dependent pathway. (2009)
  • Author(s): Awazawa M, Ueki K, Inabe K, Yamauchi T, Kanako K, Okazaki Y, Bardeesy N, Ohnishi S, Nagai R, Kadowaki T
  • Journal Title: Biochem Biophys Res Commun 382 Pages: 51-56
  • Peer Reviewed
• [Journal Article] Rimonabant ameliorates insulin resistance via both adiponectin-dependent and asiponectin-independent pathways (2009)
  • Author(s): Watanabe T, Kubota N, Ohsugi M, Kubota T, Takammoto I, Iwabu M, Awazawa M, Katsuyama H, Hasegawa C, Tokuyama K, Moroi M, Sugi K, Ymauchi T, Noda T, Nagai R, Terauchi Y, Tobe K, Ueki K, Kadowaki T
  • Journal Title: J Biol Chem 284 Pages: 1803-1812
  • Peer Reviewed
• [Journal Article] The role of the liver in glucose homeostasis in PI 3-kinase p85{alpha}-deficient mice. (2009)
  • Author(s): Aoki K, Matsui J, Kubota N, Nakajima H, Iwamoto K, Takamoto I, Tsuji Y, Iwamoto K, Takamoto I, Tsuji Y, Ohno A, Mori S, Tokuyama K, Murakami K, asano T, Aizawa S, Tobe K, Kadowaki T, Terauchi Y
  • Journal Title: Am J Physiol Endocrinol Metab 296 Pages: 842-853
  • Peer Reviewed
• [Journal Article] The death effector domain-containing DEDD supports S6K1 activity via preventing Cdk1-dependent inhibitory phosphorylation (2009)
  • Author(s): Kurabe N, Arai S, Nishijima A, Kubota N, Suizu F, Mori M, Kurokawa J, Kondo-Miyazaki M, Ide T, Murakami K, Miyake K, Ueki K, Koga H, Yatomi Y, Tashiro F, Noguchi M, Kadowaki T, Miyazaki T.
  • Journal Title: J Biol Chem 284 Pages: 5050-5055
  • Peer Reviewed
• [Journal Article] Impact of small-molecule glucokinase activator on glucose metabolism and beta-cell mass (2009)
  • Author(s): Nakamura A, Terauchi Y, Ohyama S, Kubota J, shimazaki H, Nambu T, Takamoto I, Kubota N, Eiki J, Yoshioka N, Kadowaki T, Koike T
  • Journal Title: Endocrinology 150 Pages: 1147-1154
  • Peer Reviewed
• [Journal Article] Dynamic functional relay between insulin receptor substrate-1 and -2 in hepatic insulin signaling during fasting and feeding (2008)
  • Author(s): Kubota N, Ueki K, Kadowaki T
  • Journal Title: Cell Metabolism Volume: 8 Pages: 49-64
  • DOI: 10.1016/j.cmet.2008.05.007
• [Journal Article] Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus (2008)
  • Author(s): Yasuda K, Hara K, Kadowaki T
  • Journal Title: Nature Genetics Volume: 40 Pages: 1092-1097
  • DOI: 10.1038/ng.207
• [Journal Article] SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations (2008)
  • Author(s): Unoki H, Hara K, Kadowaki T
  • Journal Title: Nature Genetics Volume: 40 Pages: 1098-1102
  • DOI: 10.1038/ng.208
• [Journal Article] Adiponectin induces insulin secretion in vitro and in vivo at a low glucose concentration (2008)
  • Author(s): Okamoto M, Kubota N, Kadowaki T
  • Journal Title: Diabetologia Volume: 51 Pages: 827-835
  • DOI: 10.1007/s00125-008-0944-9
• [Journal Article] SUMOylation of Kruppel-like transcription factor 5 acts as a molecular switch in transcriptional programs of lipid metabolism involving PPAR-delta. (2008)
  • Author(s): Oishi Y, Kubota N, Kadowaki T
  • Journal Title: Nature Medicine Volume: 14 Pages: 656-666
  • DOI: 10.1038/nm1756
• [Journal Article] In vivo imaging in mice reveals local cell dynamics and inflammation in obese adipose tissue (2008)
  • Author(s): Nishimura S, Kadowaki T
  • Journal Title: J.Clin.Invest. Volume: 118 Pages: 710-721
• [Journal Article] KLF6 in non-alcoholic fatty liver disease: role of fibrogenesis and carcinogenesis (2008)
  • Author(s): Watanabe K, Kadowaki T
  • Journal Title: Gastroenterology Volume: 135 Pages: 309-312
  • DOI: 10.1053/j.gastro.2008.06.014
• [Journal Article] Adiponectin suppresses colorectal carcinogenesis under the high-fat diet condition (2008)
  • Author(s): Fujisawa T, Kubota N, Yamauchi T, Kadowaki T
  • Journal Title: Gut Volume: 57 Pages: 1531-1538
  • DOI: 10.1136/gut.2008.159293
• [Journal Article] Glimepiride-induced bronchial asthma: case report (2008)
  • Author(s): Tsukamoto K, Kadowaki T
  • Journal Title: Diabetes Care Volume: 31
  • DOI: 10.2337/dc08-1536
• [Journal Article] Identification of neutral cholesterol ester hydrolase, a key enzyme removing cholesterol from macrophages (2008)
  • Author(s): Okazaki H, Kadowaki T
  • Journal Title: J.Biol. Chem. Volume: 283 Pages: 33357-33364
  • DOI: 10.1074/jbc.m802686200
• [Journal Article] Dynamic functional relay between insulin receptor substrate-1 and -2 in hepatic insulin signaling during fasting and feeding. (2008)
  • Author(s): Kubota N, Kubota T, Itoh S, Kumagai H, Kozono H, Takamoto I, Mineyama T, Ogata H, Tokuyama K, Ohsugi M, Sasako T, Moroi M, Sugi K, Kakuta S, Iwakura Y, Noda T, Ohnishi S, Nagai R, Tobe K, Terauchi Y, Ueki K, Kadowaki T
  • Journal Title: Cell Metabolism 8 Pages: 49-64
• [Journal Article] Adiponectin suppresses colorectal carcinogenesis under the high-fat diet condition (2008)
  • Author(s): Fujisawa T, Endo H, Tomimoto A, Sugiyama M, Takahashi H, Saito S, Inamori M,nakajima N, Watanabe M, Kubota N, Yamauchi T, Kadowaki T, Wada K, Nakagama H, Nakajima A.
  • Journal Title: Gut 57 Pages: 1531-1538
  • Peer Reviewed
• [Journal Article] 5-Hydroxytryptamine 2A receptor signaling cascade modulates adiponectin and plasminogen activator inhibitor 1 expression in adipose tissue. (2008)
  • Author(s): Uchida-Kitajima S, Ymauchi T, Takashina Y,Okada-Iwabu M, Iwabu M, Ueki K,Kadowaki T
  • Journal Title: FEBS Lett 582 Pages: 3037-3044
  • Peer Reviewed
• [Journal Article] An effecient reproductive method for Irs2-/- mice with C57BL/6JJcl genetic background (2008)
  • Author(s): Hashimoto H, Eto T, Kamisako t, Hoya N, Hatakeyama T, Arai T, Yokosuka M, Ohnishi Y, Ito M, Hioki K, Suzuki R, Osugi M, Saito M, Ueyama Y, Ymauchi T, Kubota N, Tobe K, Kadowaki T, Tamaoki N, Nomura T, Kosaka K.
  • Journal Title: Exp Anim 57 Pages: 407-411
  • Peer Reviewed
• [Journal Article] Fulminant type 1 diabetes mellitus observed in insulin receptor substrate 2 deficient mice (2008)
  • Author(s): Arai T, Hashimoto H, Kawai K, Mori A, Ohnishi Y, Hioki K, Ito M, Sito M, Ueyama Y, Ohsugi M, Suzuki R, Kubota N, Yamauchi T, Tobe K, Kadowaki T, Kosaka K
  • Journal Title: Clin Exp Med 8 Pages: 93-99
  • Peer Reviewed
• [Journal Article] Crucial role of insulin receptor substrate-2 in compensatory beta-cell hyperplasia in response to high fat diet-induced insulin resistance (2008)
  • Author(s): Takamoto I, terauchi Y, Kubota N, Ohsugi M, ueki K, Kadowaki T
  • Journal Title: Diabetes Obes Metab 10 Pages: 147-156
  • Peer Reviewed
• [Journal Article] Dynamic functional relay between insulin receptor substrate 1 and 2 in hepatic insulin signaling during fasting and feeding (2008)
  • Author(s): Kubota N, Kubota T, Itoh S, Kumagai H, Kozono H, Takamoto I, Mineyama T, Ogata H, Tokuyama K, Ohsugi M, Sasako T, Moroi M, Sugi K, Kakuta S, Iwakura Y, Noda T, Ohnishi S, Ngai R, Tobe K, Terauchi Y, Ueki K, Kadowaki T
  • Journal Title: Cell Metab 8 Pages: 49-64
  • Peer Reviewed
• [Journal Article] Impact of increased PPARgamma activity in adipocytes in vivo on adiposity, insulin sensitivity and the effects of rosiglitazone treatment (2008)
  • Author(s): Takasawa K, Kubota N, Terauchi Y, Kadowaki T.
  • Journal Title: Endocr J 55 Pages: 767-776
  • Peer Reviewed
• [Journal Article] SUMOylation ofKruppel-like transcription factor 5 acts as a molecular switch in transcriptional programs of lipid metabolism involving PPAR-delta (2008)
  • Author(s): Oishi Y, Manabe I, Tobe K, Ohsugi M, Kubota T, Fujiu K, Maemura K, KUbota N, Kadowaki T, Nagai R
  • Journal Title: Nat Med 14 Pages: 656-666
  • Peer Reviewed
• [Journal Article] Peroxisome proliferator-activated receptor gamma (PPARgamma) suppresses colonic epithelial cell turnover and colon carcinogenesis through inhibition of the beta-catein/T cell factor (TCF) pathway. (2008)
  • Author(s): Fujisawa T, Nkajima A, Fujisawa N, Tkahashi H, Ikeda I, Tomimoto A, Yonemitsu K, Nkajima N, Kudo C, Wada K, Kubota N, Terauchi Y, Kadowaki T, Nkagama H, Blumberg RS
  • Journal Title: J Pharmacol Sci 106 Pages: 627-638
  • Peer Reviewed
• [Journal Article] Adiponectin induces insulin secretion in vitro and in vivo at a low glucose concentration (2008)
  • Author(s): Wakui M, Ngai R, Noda M, Nagamatsu S, Kadoaki T
  • Journal Title: Diabetologia 51 Pages: 827-835
  • Peer Reviewed
• [Journal Article] Association of adenovirus 36 infection with obesity and metabolic markers in humans: a meta-analysis of observational studies
  • Author(s): Yamada T, Hara K, Kadowaki T
  • Journal Title: PLoS One Volume: 7
• [Presentation] AdipoRs activation increases Ca2+ and AMPK/SIRT/PGC-1, thereby regulating metabolic stress and mitochondria, leading to anti-aging and amelioration of diseases of aging (2012)
  • Author(s): Takashi Kadowaki
  • Organizer: KEYSTONE SYMPOSIA: Aging and Diseases of Aging
  • Place of Presentation: TOKYO
  • Year and Date: 2012-10-26
• [Presentation] Adiponectin and adiponectin receptors in insulin resistance and type 2 diabetes (2011)
  • Author(s): 門脇孝
  • Organizer: The World Diabetes Congress
  • Place of Presentation: Dubai, UAE(招待講演)
  • Year and Date: 2011-12-04
• [Presentation] Role of PI3 kinase in type 2 diabetes (2011)
  • Author(s): 門脇孝
  • Organizer: New Aspect of Phospholipid Biology and Medical
  • Place of Presentation: 福岡県福岡市(招待講演)
  • Year and Date: 2011-11-15
• [Presentation] 2型糖尿病の分子機構と治療戦略 (2011)
  • Author(s): 門脇孝
  • Organizer: 第108回日本内科学会講演会
  • Place of Presentation: 神奈川県横浜市(招待講演)
  • Year and Date: 2011-11-13
• [Presentation] 2型糖尿病の分子機構解明における遺伝子操作動物の意義 (2011)
  • Author(s): 門脇孝
  • Organizer: 第25回日本糖尿病・肥満動物学会年次学術集会
  • Place of Presentation: 東京
  • Year and Date: 2011-11-05
• [Presentation] 2型糖尿病の体質に関する研究-遺伝素因の解明とアディポネクチン作用低下の意義 (2011)
  • Author(s): 門脇孝
  • Organizer: 第61回日本体質医学会総会
  • Place of Presentation: 東京
  • Year and Date: 2011-10-08
• [Presentation] 我が国におけるウエスト周囲径・メタボリックシンドロームに関するエビデンス (2011)
  • Author(s): 門脇孝
  • Organizer: 第32回日本肥満学会
  • Place of Presentation: 兵庫県淡路市(招待講演)
  • Year and Date: 2011-09-23
• [Presentation] 1st International Conference on Immuno Metabolism (2011)
  • Author(s): 門脇孝
  • Organizer: Adiponectin and adiponectin receptors in insulin resistance and type2 diabetes
  • Place of Presentation: Crete, Greese(招待講演)
  • Year and Date: 2011-09-19
• [Presentation] Insulin and adiponectin pathways in type2 diabetes (2011)
  • Author(s): 門脇孝
  • Organizer: Dundee Diabetes Research Centre Annual Lecture Seminar
  • Place of Presentation: Dundee, Scotland(招待講演)
  • Year and Date: 2011-09-16
• [Presentation] Adiponectin action through AMPK (2011)
  • Author(s): Takashi Kadowaki
  • Organizer: American Diabetes Association 71st Scientific Sessions
  • Place of Presentation: San Diego, USA
  • Year and Date: 2011-06-26
• [Presentation] Adiponectin action through AMPK (2011)
  • Author(s): 門脇孝
  • Organizer: American Diabetes Association 71st Scientific Sessions
  • Place of Presentation: San Diego, USA(招待講演)
  • Year and Date: 2011-06-26
• [Presentation] Adiponectin & Adipose Tissue (2011)
  • Author(s): 門脇孝
  • Organizer: Endo 2011
  • Place of Presentation: Boston, USA(招待講演)
  • Year and Date: 2011-06-05
• [Presentation] Multiple aspects of molecular mechanism of insulin resistance in type2 diabetes (2011)
  • Author(s): Takashi Kadowaki
  • Organizer: 76th Cold Spring Harbor Laboratory Symposium
  • Place of Presentation: Cold Spring Harbor, USA
  • Year and Date: 2011-06-02
• [Presentation] Multiple aspects of molecular mechanism of insulin resistance in type 2 diabetes (2011)
  • Author(s): 門脇孝
  • Organizer: 76th Cold Spring Harbor Laboratory Symposium
  • Place of Presentation: Cold Spring Harbor, USA(招待講演)
  • Year and Date: 2011-06-02
• [Presentation] 生活習慣病からみた抗加齢医学 (2011)
  • Author(s): 門脇孝
  • Organizer: 第11回日本抗加齢医学会総会
  • Place of Presentation: 京都府京都市(招待講演)
  • Year and Date: 2011-05-28
• [Presentation] 災害時の糖尿病医療-日本糖尿病学会の対応と今後の対応 (2011)
  • Author(s): 門脇孝
  • Organizer: 第54回日本糖尿病学会年次学術集会緊急シンポジウム「災害時の糖尿病医療」
  • Place of Presentation: 北海道札幌市
  • Year and Date: 2011-05-19
• [Presentation] 糖尿病と病理Pathological aspects of diabetes (2011)
  • Author(s): 門脇孝
  • Organizer: 第100回日本病理学会総会
  • Place of Presentation: 神奈川県横浜市(招待講演)
  • Year and Date: 2011-04-29
• [Presentation] Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca2+ signalling and AMPK/SIRT1 like exercise. (2010)
  • Author(s): Yamauchi T, Iwabu M, Okada-Iwabu M, Ueki K, Kadowaki T
  • Organizer: 46^<th> Annual Meeting of the European Association for the Study of Diabetes.
  • Place of Presentation: Stockholm
  • Year and Date: 2010-09-22
• [Presentation] Adiponectin and AdipoRl regulate PGC-lalpha and mitochondria by Ca^<2+> signalling and AMPK/SIRTl like exercise. (2010)
  • Author(s): Yamauchi T. Iwabu M. Okada-Iwabu M, Ueki K, Kadowaki T
  • Organizer: 6^<th>Annual Meeting of the European Association for the Study of Diabetes.
  • Place of Presentation: Stockholm, Sweden
  • Year and Date: 2010-09-22
• [Presentation] Role of adiponectin/AdipoR1 in skeletal muscle in mitochondrial biogenesis, exercise endurance and insulin sensitivity. (2010)
  • Author(s): Kadowaki T
  • Organizer: The 14th International Congress of Endocrinology(ICE2010)
  • Place of Presentation: 京都
  • Year and Date: 2010-03-28
• [Presentation] Role of Adiponectin and Adiponectin Receptors in Insulin Resistance (2010)
  • Author(s): 門脇孝
  • Organizer: The official Satellite Symposium of the 14^<th> ICE2010
  • Place of Presentation: 東京
  • Year and Date: 2010-03-25
• [Presentation] Adiponectin : a key Regulator of Diabetes and Cancer (2010)
  • Author(s): 門脇孝
  • Organizer: A symposium at Institute Pasteur Korea
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2010-02-19
• [Presentation] 生活習慣病の成因・治療のエビデンスと管理栄養士の使命 (2010)
  • Author(s): 門脇孝
  • Organizer: 第13回日本病態栄養学会
  • Place of Presentation: 京都
  • Year and Date: 2010-01-09
• [Presentation] Inflammation and the Metabolic Syndrome (2009)
  • Author(s): 門脇孝
  • Organizer: Asia Pacific Conference on the Metabolic Syndrome
  • Place of Presentation: Melbourne, Australia
  • Year and Date: 2009-11-21
• [Presentation] アディポサイトカインと心血管内分泌代謝学 (2009)
  • Author(s): 門脇孝
  • Organizer: 第13回日本心血管内分泌代謝学会学術総会
  • Place of Presentation: 埼玉
  • Year and Date: 2009-10-24
• [Presentation] Adipocyte. (2009)
  • Author(s): Kadowaki T
  • Organizer: 20^<th> World Diabetes Congress(IDF)
  • Place of Presentation: Montreal
  • Year and Date: 2009-10-20
• [Presentation] Adipocyte (2009)
  • Author(s): 門脇孝
  • Organizer: 20^<th> World Diabetes Congress(IDF)
  • Place of Presentation: Montreal, Canada
  • Year and Date: 2009-10-20
• [Presentation] 糖尿病ガイドライン:治療の面から (2009)
  • Author(s): 門脇孝
  • Organizer: 第57回日本心臓学会学術集会
  • Place of Presentation: 北海道
  • Year and Date: 2009-09-20
• [Presentation] 2型糖尿病の体質とそれをふまえた治療戦略 (2009)
  • Author(s): 門脇孝
  • Organizer: 日本体質医学会
  • Place of Presentation: 東京
  • Year and Date: 2009-07-25
• [Presentation] 肥満とアディポカイン-メタボリックシンドロームを理解する- (2009)
  • Author(s): 門脇孝
  • Organizer: 第2回日本肥満症治療学会
  • Place of Presentation: 東京
  • Year and Date: 2009-07-11
• [Presentation] The Rule of IRS2 in Hepatic Insulin Sensitivity. (2009)
  • Author(s): Kadowaki T
  • Organizer: American Diabetes Association 69^<th> Scientific Sessions
  • Place of Presentation: Louisiana
  • Year and Date: 2009-06-06
• [Presentation] The Rule of IRS2 in Hepatic Insulin Sensitivuty (2009)
  • Author(s): 門脇孝
  • Organizer: American Diabetes Association 69^<th> Scientific Sessions
  • Place of Presentation: Louisiana, U.S.A.
  • Year and Date: 2009-06-06
• [Presentation] 糖尿病患者の新たなる治療ステージ (2009)
  • Author(s): 門脇孝
  • Organizer: 第52回日本糖尿病学会年次学術集会総会
  • Place of Presentation: 大阪
  • Year and Date: 2009-05-23
• [Presentation] 発生工学的研究を用いた糖尿病創薬研究の戦略 (2009)
  • Author(s): 門脇孝
  • Organizer: 第56回日本実験生物学会総会
  • Place of Presentation: 埼玉
  • Year and Date: 2009-05-14
• [Presentation] 糖尿病・メタボリックシンドロームの病態と治療戦略-最近の知見- (2009)
  • Author(s): 門脇孝
  • Organizer: 第46回日本臨床分子医学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2009-04-12
• [Presentation] Epidemic of type 2 diabetes in Japan-Its causes and preventive strategies. (2009)
  • Author(s): Kadowaki T
  • Organizer: 3^<rd> International Congress on Prediabetes and the Metabolic Syndrome.
  • Place of Presentation: Nice
  • Year and Date: 2009-04-02
• [Presentation] Epidemic of type 2 diabetes in Japan-Its causes and preventive strategies (2009)
  • Author(s): 門脇孝
  • Organizer: 3^(rd) International Congress on Pre diabetes and the Metabolic Syndrome
  • Place of Presentation: Nice, France
  • Year and Date: 2009-04-02
• [Presentation] 遺伝子操作動物を用いた糖尿病研究の戦略 (2009)
  • Author(s): 門脇孝
  • Organizer: 第23回日本糖尿病・肥満動物学会年次学術集会
  • Place of Presentation: 岡山
  • Year and Date: 2009-02-13
• [Presentation] AMPK in sickness and health from molecule to man (2008)
  • Author(s): 門脇孝
  • Organizer: FASEB SUMMER RESEARCH CONFERENCES
  • Place of Presentation: Copenhagen
  • Year and Date: 2008-08-14
• [Presentation] メタボリック症候群とアディボカイン (2008)
  • Author(s): 門脇孝
  • Organizer: 第51回日本腎臓学会学術総会
  • Place of Presentation: 福岡
  • Year and Date: 2008-06-01
• [Presentation] 2型の糖尿病の成因を追い求める旅」-真理への希求- (2008)
  • Author(s): 門脇孝
  • Organizer: 第51回日本糖尿病学会年次学術集会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-22
• [Presentation] Adiponectin and its receptors in insulin resistance, diabetes and metabolic syndrome and obesity (2008)
  • Author(s): 門脇孝
  • Organizer: 10^<th> European Congress of Endocrinology
  • Place of Presentation: berlin
  • Year and Date: 2008-05-06
• [Presentation] 2型糖尿病の分子機構－インスリンとアディポネクチン作用を中心に
  • Author(s): 門脇 孝
  • Organizer: 第85回日本内分泌学会学術総会
  • Place of Presentation: 名古屋
  • Invited
• [Presentation] 糖尿病と炎症
  • Author(s): 門脇 孝
  • Organizer: 第77回日本インターフェロン・サイトカイン学会学術集会
  • Place of Presentation: 神戸
  • Invited
• [Presentation] 糖尿病と炎症
  • Author(s): 門脇 孝
  • Organizer: 第33回日本炎症・再生医学会
  • Place of Presentation: 福岡
  • Invited
• [Presentation] Molecular Mechanism of Type 2 Diabetes
  • Author(s): 門脇 孝
  • Organizer: ISPAD Science School for Physicians 2012 in Kyoto Special Lecture
  • Place of Presentation: 京都
  • Invited
• [Presentation] アディポネクチンを中心とした抗加齢戦略
  • Author(s): 門脇 孝
  • Organizer: 日本抗加齢医学会主催エデュケーショナルセミナー
  • Place of Presentation: 東京
  • Invited
• [Presentation] 糖尿病と炎症－歯周病を含めて
  • Author(s): 門脇 孝
  • Organizer: 第55回秋季日本歯周病学会学術大会
  • Place of Presentation: 茨城
  • Invited
• [Presentation] 2型糖尿病の分子基盤－真理の探究
  • Author(s): 門脇 孝
  • Organizer: 第8回臨床分子医学研究会
  • Place of Presentation: 京都
  • Invited
• [Presentation] 若手医師のための糖尿病講義
  • Author(s): 門脇 孝
  • Organizer: 第47回糖尿病学の進歩
  • Place of Presentation: 四日市
  • Invited
• [Presentation] Molecular Mechanism of Type 2 Diabetes
  • Author(s): Takashi Kadowaki
  • Organizer: 2012 Kroc Lecture
  • Place of Presentation: Chicago, USA
  • Invited
• [Presentation] Molecular Mechanism of Type 2 Diabetes
  • Author(s): Takashi Kadowaki
  • Organizer: Lecture in the Feinberg School of Medicine of Northwestern University
  • Place of Presentation: Chicago, USA
  • Invited
• [Presentation] Tofogliflozin, a Novel and Selective SGLT2 Inhibitor Improves Glycemic Control and Lowers Body Weight in Patients with Type 2 Diabetes Mellitus Inadequately Controlled on Stable Metformin or Diet and Exercise Alone
  • Author(s): Takashi Kadowaki
  • Organizer: American Diabetes Association 72st Scientific Sessions
  • Place of Presentation: Philadelphia, USA
• [Presentation] AdipoRs Activation Reduced Ectopic Fat Accumulation and Inflammation, Leading to Improved Glucose/ Lipid Metabolism
  • Author(s): Takashi Kadowaki
  • Organizer: The 64th FUJIHARA SEMINAR International Symposium on Adiponectin Biology and Medicine
  • Place of Presentation: Tomakomai, Japan
  • Invited
• [Presentation] AdipoRs activation increases Ca2＋and AMPK/SIRT/PGC-1, thereby regulating metabolic stress and mitochondria, leading to anti-aging and amelioration of diseases of aging
  • Author(s): Takashi Kadowaki
  • Organizer: KEYSTONE SYMPOSIA: Aging and Diseases of Aging
  • Place of Presentation: Tokyo, Japan
  • Invited
• [Presentation] Molecular Mechanism of Insulin Resistance in Type 2 Diabetes
  • Author(s): Takashi Kadowaki
  • Organizer: 9th IDF-WPR Congress
  • Place of Presentation: Kyoto, Japan
  • Invited
• [Presentation] A novel and Selective SGLT2 inhibitor, tofogliflozin improves glycemic control and lowers body weight in patients with type 2 diabetes mellitus
  • Author(s): Takashi Kadowaki
  • Organizer: 9th IDF-WPR Congress
  • Place of Presentation: Kyoto, Japan
• [Book] 最新臨床糖尿病学上－糖尿病学の最新動向－ I．総論 日本糖尿病学会のアクションプラン2010（DREAMS） (2012)
  • Author(s): 門脇 孝
  • Total Pages: 9
  • Publisher: 日本臨牀
• [Book] 最新臨床糖尿病学上－糖尿病学の最新動向－ IV．糖尿病の疾患概念・病型分類・成因 2型糖尿病 2型糖尿病の疾患概念 (2012)
  • Author(s): 門脇 孝
  • Total Pages: 8
  • Publisher: 日本臨牀
• [Book] HbA1c国際標準化－日常臨床での運用の実際と啓発の重要性 (2012)
  • Author(s): 門脇 孝
  • Total Pages: 13
  • Publisher: Diabetes Journal
• [Book] アディポネクチンとその受容体-抗生活習慣病ホルモンの全貌(単行本) (2008)
  • Author(s): 門脇孝
  • Publisher: フジメディカル出版
• [Book] あなたがメタボになる理由(単行本) (2008)
  • Author(s): 門脇孝
  • Publisher: PHP研究所
• [Remarks]
  • URL: http://dm301k.umin.jp/
• [Remarks]
  • URL: http://dm301k.umin.jp/
• [Patent(Industrial Property Rights)] 擬似運動療法のための医薬 (2011)
  • Inventor(s): 門脇孝、山内敏正、他2名
  • Industrial Property Rights Holder: (株)東京大学TLO
  • Filing Date: 2011-03-15
  • Application Year: 2011
  • Overseas
• [Patent(Industrial Property Rights)] アディポネクチン受容体及びそれをコードする遺伝子 (2010)
  • Inventor(s): 門脇孝、山内敏正、他2名
  • Industrial Property Rights Holder: 東京大学TLO、日産化学工業(株)
  • Acquisition Date: 2010-01-22
  • Acquisition Year: 2010