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Integrated elucidation of metabolic pathway in the physiology and pathology

Research Project

Project/Area Number 20229008
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Metabolomics
Research InstitutionThe University of Tokyo

Principal Investigator

KADOWAKI Takashi  東京大学, 医学部附属病院, 教授 (30185889)

Co-Investigator(Kenkyū-buntansha) UEKI Kohjiro  東京大学, 医学部附属病院, 准教授 (00396714)
YAMAUCHI Toshimasa  東京大学, 医学部附属病院, 講師 (40372370)
Co-Investigator(Renkei-kenkyūsha) HARA Kazuo  東京大学, 医学部附属病院, 特任准教授 (50359600)
KUBOTA Naoto  東京大学, 医学部附属病院, 特任准教授 (50396719)
Project Period (FY) 2008 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥227,240,000 (Direct Cost: ¥174,800,000、Indirect Cost: ¥52,440,000)
Fiscal Year 2012: ¥28,080,000 (Direct Cost: ¥21,600,000、Indirect Cost: ¥6,480,000)
Fiscal Year 2011: ¥28,080,000 (Direct Cost: ¥21,600,000、Indirect Cost: ¥6,480,000)
Fiscal Year 2010: ¥28,080,000 (Direct Cost: ¥21,600,000、Indirect Cost: ¥6,480,000)
Fiscal Year 2009: ¥41,600,000 (Direct Cost: ¥32,000,000、Indirect Cost: ¥9,600,000)
Fiscal Year 2008: ¥101,400,000 (Direct Cost: ¥78,000,000、Indirect Cost: ¥23,400,000)
Keywordsアディポネクチン / インスリン / AdipoR / 糖代謝 / 脂質代謝
Research Abstract

An integrated understanding of metabolic regulation and its disruption is essential in elucidating the pathophysiology of diabetes and the metabolic syndrome as well as in developing therapeutic modalities for these conditions. In this connection, we contributed to generating scientific evidence that constitutes a basis for the development of anti妖iabetic therapies targeted at the regulation of insulin and/or adiponectin action as well as to the discovery of candidate anti-diabetic compounds, by elucidating the mechanisms involved in the inter-organ cross-walks in the regulation of insulin and/or adiponectin action.

Assessment Rating
Verification Result (Rating)

A+

Report

(8 results)
  • 2013 Research Progress Assessment (Verification Result) ( PDF )
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report   Self-evaluation Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (188 results)

All 2013 2012 2011 2010 2009 2008 Other

All Journal Article (122 results) (of which Peer Reviewed: 71 results) Presentation (57 results) (of which Invited: 13 results) Book (5 results) Remarks (2 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 1 results)

  • [Journal Article] Adiponectin receptor as a key player in healthy longevity and obesity-related diseases2013

    • Author(s)
      Yamauchi T, Kadowaki T.
    • Journal Title

      Cell Metab

      Volume: 17 Issue: 2 Pages: 185-196

    • DOI

      10.1016/j.cmet.2013.01.001

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Baseline predictive factors for glycemic control in Japanese type 2 diabetes patients treated with insulin glargine plus oral antidiabetic drugs: ALOHA study subanalysis2013

    • Author(s)
      Kadowaki T, Ohtani T, Odawara M.
    • Journal Title

      Diabetol Int

      Volume: 4 Pages: 16-22

    • NAID

      10030925706

    • Related Report
      2012 Final Research Report
  • [Journal Article] Efficacy, safety and dose-desponse relationship of teneligliptin, a dipeptidyl peptidase-4 inhibitor, in Japanese patients with type 2 diabetes mellitus2013

    • Author(s)
      Kadowaki T, Kondo K.
    • Journal Title

      Diabetes Obes Metab

      Volume: - Issue: 9 Pages: 810-818

    • DOI

      10.1111/dom.12092

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide Association Study Identifies a Novel Locus Contributing to Type 2 Diabetes Susceptibility in Sikhs of Punjabi Origin From India2013

    • Author(s)
      Saxena R, Yamauchi T, Hara K Saxena R, Yamauchi T, Hara K DIAGRAM MuTHER; TGEN, Kadowaki T
    • Journal Title

      Diabetes

      Volume: 62 Issue: 5 Pages: 1746-1755

    • DOI

      10.2337/db12-1077

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Baseline predictive factors for glycemic control in Japanese type 2 diabetes patients treated with insulin glargine plus oral antidiabetic drugs: ALOHA study subanalysis.2013

    • Author(s)
      Kadowaki T, Ohtani T, Odawara M
    • Journal Title

      Diabetol Int.

      Volume: 4 Pages: 16-22

    • NAID

      10030925706

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide association study in a Chinese population identifies a susceptibility locus for type 2 diabetes at 7q32 near PAX42013

    • Author(s)
      Ma R. C. W., Hu C., Tam C. H.,..., Hara K.,..., Yamauchi T.,..., Kadowaki T., Tai E. S., Zeggini E., McCarthy M. I., Hon K. L., Baum L., Tomlinson B., So W. Y., Bao Y., Chan J. C. N., Jia W
    • Journal Title

      Diabetologia

      Volume: -

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diabetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium, Nakamura Y, Kadowaki T: A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations2012

    • Author(s)
      Imamura M,1,Yamauchi T, Hara K, Okada-Iwabu M, Iwabu M
    • Journal Title

      Human Molecular Genatics

      Volume: 21 Pages: 3042-3049

    • Related Report
      2012 Final Research Report
  • [Journal Article] Expression-based genome-gide association study links CD44 in adipose tissue with type 2 diabetes2012

    • Author(s)
      Kodama K, Hara K, Kadowaki T, Butte AJ
    • Journal Title

      Proc. Natl. Acad. Sci. USA

      Volume: 109 Issue: 18 Pages: 7049-7054

    • DOI

      10.1073/pnas.1114513109

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cntrol of beta cell function and proliferation in mice stimulated by small-molecule glucokinase activator under various conditions2012

    • Author(s)
      Nakamura A, Kubota N, Kadowaki T
    • Journal Title

      Diabatologia

      Volume: 55 Pages: 1745-1754

    • Related Report
      2012 Final Research Report
  • [Journal Article] Saturated fatty acid and TLR signaling link (3 cell dysfunction and islet inflammation2012

    • Author(s)
      Eguchi K, Kadowaki T
    • Journal Title

      Cell Metal

      Volume: 15 Pages: 518-533

    • Related Report
      2012 Final Research Report
  • [Journal Article] Genetic risk score constructed using 14 susceptibility alleles for type 2 diabetes is associated with the early onset of diabetes and may predict the future requirement of insulin injections among Japanese individuals2012

    • Author(s)
      Iwata M, Hara K, Kadowaki T
    • Journal Title

      Diabetes Care

      Volume: 35 Issue: 8 Pages: 1763-1770

    • DOI

      10.2337/dc11-2006

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Potential Formula for the Calculation of Starting and Incremental Insulin Glargine Doses: ALOHA Subanalysis2012

    • Author(s)
      Kadowaki T, Ohtani T, Odawara M
    • Journal Title

      PLoSOne

      Volume: 7 Issue: 7 Pages: e41353-e41353

    • DOI

      10.1371/journal.pone.0041353

    • Related Report
      2012 Final Research Report
  • [Journal Article] Depletion of homeodomain-interacting protein kinase 3 impairs insulin secretion and glucose tolerance in mice2012

    • Author(s)
      Shojima N, Hara K, Kubota N, Yamauchi T, Ueki K, Kadowaki T
    • Journal Title

      Diabetologia

      Volume: 55 Issue: 12 Pages: 3318-3330

    • DOI

      10.1007/s00125-012-2711-1

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Erectile dysfunction and cardiovascular events in diabetic menmeta-analysis of observational studies2012

    • Author(s)
      Yamada T, Hara K, Umematsu H, Suzuki R, Kadowaki T.
    • Journal Title

      PLoS One

      Volume: 7 Issue: 9 Pages: e43673-e43673

    • DOI

      10.1371/journal.pone.0043673

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Variations with modest effects have an important role in the genetic background of type 2 diabetes and diabetes-related traits2012

    • Author(s)
      Fujita H, Hara K, Kadowaki T
    • Journal Title

      J Hum Genet

      Volume: 57 Issue: 12 Pages: 776-779

    • DOI

      10.1038/jhg.2012.110

    • NAID

      10031145885

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Snap Shot: Insulin Signaling Pathways2012

    • Author(s)
      Kadowaki T, Ueki K, Yamauchi T, Kubota N.
    • Journal Title

      Cep

      Volume: 148 Pages: 624-624

    • Related Report
      2012 Final Research Report
  • [Journal Article] SnapShot: Physiology of Insulin Signaling2012

    • Author(s)
      Kadowaki T, Kubota N, Ueki K, Yamauchi T
    • Journal Title

      Ce11

      Volume: 148 Pages: 834-834

    • Related Report
      2012 Final Research Report
  • [Journal Article] Monocyte chemoattractant protein-1 (MCP-1) deficiency enhances alternatively activated M2 macrophages and ameliorates insulin resistance and fatty liver in lipoatrophic diabetic A-ZIP transgenic mice2012

    • Author(s)
      Nio Y, Yamauchi T, Iwabu M, Okada-Iwabu M, Ueki K, Kadowaki T
    • Journal Title

      Diabetologia

      Volume: 55 Issue: 12 Pages: 3350-3358

    • DOI

      10.1007/s00125-012-2710-2

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations.2012

    • Author(s)
      Imamura M, Maeda S, Yamauchi T, Hara K, Yasuda K,..., Okada-Iwabu M, Iwabu M, Shojima N,..., Nakamura Y, Kadowaki T
    • Journal Title

      Human Molecular Genetics

      Volume: 21 Issue: 13 Pages: 3042-3049

    • DOI

      10.1093/hmg/dds113

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Control of beta cell function and proliferation in mice stimulated by small-molecule glucokinase activator under various conditions2012

    • Author(s)
      Nakamura A, Togashi Y, Orime K, Sato K, Shirakawa J, Ohsugi M, Kubota N, Kadowaki T, Terauchi Y
    • Journal Title

      Diabetologia

      Volume: (In press) Issue: 6 Pages: 1745-1754

    • DOI

      10.1007/s00125-012-2521-5

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Saturated fatty acid and TLR signaling link β cell dysfunction and islet inflammation.2012

    • Author(s)
      Eguchi K, Manabe I, Oishi-Tanaka Y, Ohsugi M, Kono N, Ogata F, Yagi N, Ohto U, Kimoto M, Miyake K, Tobe K, Arai H, Kadowaki T, Nagai R
    • Journal Title

      Cell Metab.

      Volume: 15 Issue: 4 Pages: 518-533

    • DOI

      10.1016/j.cmet.2012.01.023

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Potential Formula for the Calculation of Starting and Incremental Insulin Glargine Doses: ALOHA Subanalysis.2012

    • Author(s)
      Kadowaki T, Ohtani T, Odawara M
    • Journal Title

      PLoS One

      Volume: 7 Issue: 8 Pages: e41358-e41358

    • DOI

      10.1371/journal.pone.0041358

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of adenovirus 36 infection with obesity and metabolic markers in humans: a meta-analysis of observational studies.2012

    • Author(s)
      Yamada T, Hara K, Kadowaki T
    • Journal Title

      PLoS One

      Volume: 7 Issue: 7 Pages: e42031-e42031

    • DOI

      10.1371/journal.pone.0042031

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] SnapShot : Physiology of Insulin Signaling2012

    • Author(s)
      Kadowaki T, Kubota N, Ueki K, Yamauchi T
    • Journal Title

      Cell

      Volume: 148 Issue: 4 Pages: 834-834

    • DOI

      10.1016/j.cell.2012.02.004

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] SnapShot : Insulin Signaling Pathways2012

    • Author(s)
      Kadowaki T, Ueki K, Yamauchi T, Kubota N
    • Journal Title

      Cell

      Volume: 148 Issue: 3 Pages: 624-624

    • DOI

      10.1016/j.cell.2012.01.034

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokine and integrin signaling2011

    • Author(s)
      S.Nishimura
    • Journal Title

      Blood

      Volume: 119 Issue: 8 Pages: 128-131

    • DOI

      10.1182/blood-2011-09-381400

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle2011

    • Author(s)
      Kubota T, Kubota N, Ueki K, Kadowaki T
    • Journal Title

      Cell Metabolism

      Volume: 13 Pages: 294-307

    • Related Report
      2012 Final Research Report
  • [Journal Article] Adiponectin enhances insulin sensitivity by increasing hepatic IRS-2 expression via a macrophage妖erived IL-6 dependent pathway2011

    • Author(s)
      Awazawa M, Ueki K, Yamauchi T, Kubota, Kadowaki T
    • Journal Title

      Cell Metabolism

      Volume: 13 Issue: 4 Pages: 401-412

    • DOI

      10.1016/j.cmet.2011.02.010

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Global mapping of cell type-specific open chromatin by FAIRE-seq reveals the regulatory role of the NFI family in adipocyte differentiation2011

    • Author(s)
      Waki H, Nakamura M, Yamauchi T, Wakabayashi K, Yu J, Hirose-Yotsuya L, Take K, Sun W, Iwabu M, Okada-Iwabu M, Fujita T, Aoyama T, Tsutsumi S, Ueki K, Kodama T, Sakai J, Aburatani H, Kadowaki
    • Journal Title

      PLos Genetics

      Volume: 7 Issue: 10 Pages: e1002311-e1002311

    • DOI

      10.1371/journal.pgen.1002311

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Blockade of class lB phosphor inositide-3 kinase ameliorates obesity induced inflammation and insulin resistance2011

    • Author(s)
      Kobayashi N, Ueki, Kubota N, Hara K, Kadowaki T
    • Journal Title

      Proc. Nat/. Acad. Sci. U.S.A.

      Volume: 108 Pages: 5753-5758

    • Related Report
      2012 Final Research Report
  • [Journal Article] Crystal structure of the Ca2+/Calmodulin-dependent protein kinase in complex with the inhibitor STO-6092011

    • Author(s)
      Kukimoto-Nino M, Yamauchi T, Okada Iwabu M, Iwabu M, Kadowaki T
    • Journal Title

      J. Biol. Chem.

      Volume: 286 Issue: 25 Pages: 22570-22579

    • DOI

      10.1074/jbc.m111.251710

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians2011

    • Author(s)
      Cho YS, Yamauchi T, Hara K, Kadowaki T
    • Journal Title

      Nature Genatics

      Volume: 44 Issue: 1 Pages: 67

    • DOI

      10.1038/ng.1019

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The other sweet face of XBP-12011

    • Author(s)
      Ueki K, Kadowaki T
    • Journal Title

      Nature Medicine

      Volume: 17 Issue: 3 Pages: 246-248

    • DOI

      10.1038/nm0311-246

    • Related Report
      2012 Final Research Report
  • [Journal Article] Adiponectin receptor signaling: a new layer to the current model2011

    • Author(s)
      Kadowaki T, Yamauchi T
    • Journal Title

      Cell Metabolism

      Volume: 13 Issue: 2 Pages: 123-124

    • DOI

      10.1016/j.cmet.2011.01.012

    • Related Report
      2012 Final Research Report
  • [Journal Article] Thiazolidinediones enhance sodium-coupled bicarbonate absorption from renal proximal tubules via PPARγ-dependent nongenomic signaling2011

    • Author(s)
      Endo Y, Yamauchi T, Kubota N, Kadowaki T
    • Journal Title

      CellMetabolism

      Volume: 13 Issue: 5 Pages: 550

    • DOI

      10.1016/j.cmet.2011.02.015

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Apoptosis inhibitor of macrophage (AIM) is required for obesity-associated recruitment of inflammatory macrophages into adipose tissue2011

    • Author(s)
      Jun Kurokawa, et al
    • Journal Title

      Proc.Natl.Acad.Sci.USA.

      Volume: vol.108 Issue: 29 Pages: 12072-12077

    • DOI

      10.1073/pnas.1101841108

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Loss of adiponectin promotes intestinal carcinogenesis in Min and wild-type mice2011

    • Author(s)
      Mutoh M, Kubota N, Kadowaki T
    • Journal Title

      Gastroenterology

      Volume: 140 Issue: 7 Pages: 2000-2008

    • DOI

      10.1053/j.gastro.2011.02.019

    • Related Report
      2012 Final Research Report
  • [Journal Article] The diabetogenic VPS13C/C2CD4A/C2CD4B rs7172432 variant impairs glucose-stimulated insulin response in 5,722 non-diabetic Danish individuals2011

    • Author(s)
      Grarup N, Yamauchi T, Hara K, Kadowaki T
    • Journal Title

      Diabetologia

      Volume: 54 Issue: 4 Pages: 789-794

    • DOI

      10.1007/s00125-010-2031-2

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evi1 is essential for hematopoietic stem cell self-renewal, and its expression marks hematopoietic cells with long-term multilineage repopulating activity2011

    • Author(s)
      Keisuke Kataoka
    • Journal Title

      The Journal of Experimental Medicine

      Volume: 208 Issue: 12 Pages: 2403-2416

    • DOI

      10.1084/jem.20110447

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Metabolomic analysis reveals hepatic metabolite perturbations in citrin/mitochondrial glycerol-3-phosphate dehydrogenase double-knockout mice, a model of human citrin deficiency2011

    • Author(s)
      Saheki T, Inoue K, Ono H, Tushima A, Katsura N, Yokogawa M, Yoshidumi Y, Kuhara T, Ohse M, Eto K, Kadowaki T, Sinasac DS, Kobayashi K
    • Journal Title

      Mol Genet Metab

      Volume: 104 Issue: 4 Pages: 492-500

    • DOI

      10.1016/j.ymgme.2011.08.015

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Possibility of increasing cholesterol efflux by adiponectin and its receptors through the ATP binding cassette transporter A1 in HEK293T cells2011

    • Author(s)
      Kitajima, K,Miura S, Yamauchi T, Uehara Y, Kiya Y, Rye KA, Kadowaki T, Saku K
    • Journal Title

      Biochem.Biophys.Res.Commun.

      Volume: 411 Issue: 2 Pages: 305-311

    • DOI

      10.1016/j.bbrc.2011.06.131

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Blockade of class IB phosphoinositide-3 kinase ameliorates obesity-induced inflammation and insulin resistance2011

    • Author(s)
      Kobayashi N, Ueki K, Okazaki Y, Iwane A, Kubota N, Ohsugi M, Awazawa M, Kobayashi M, Sasako T, Kaneko K, Suzuki M, Nishikawa Y, Hara K, Yoshimura K, Koshima I, Goyama s, Murakami K, Sasaki J, Nagai R, Kurokawa M, Sasaki T, Kadowaki T
    • Journal Title

      Proc.Natl.Acad.Sci.USA

      Volume: 108 Issue: 14 Pages: 5753-5758

    • DOI

      10.1073/pnas.1016430108

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thiazolidinediones Enhance Sodium-Coupled Bicarbonate Absorption from Renal Proximal Tubules via PPARγ-Dependent Nongenomic Signaling2011

    • Author(s)
      Endo Y, Suzuki M, Yamada H, Horita s, Kunimi M, Yamazaki O, Shirai A, Nakamura M, Iso-O N, Li Y, Hara M, Tsukamoto K, Moriyama N, Kudo A, Kawakami H, Yamauchi T, Kubota N, Kadowaki T, Kume H, Enomoto Y, Homma Y, Seki G, Fujita T
    • Journal Title

      Cell Metabolism

      Volume: 13 Pages: 550-561

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adiponectin enhances insulin sensitivity by increasing hepatic IRS-2 expression via macrophage-derived IL-6 dependent pathway.2011

    • Author(s)
      Awazawa M, Ueki K, Inabe K, Yamauchi T, Kubota N, Kaneko K, Kobayashi M, Iwane A, Sasako T, Ohsugi M, Takamoto I, Yamashita S, Asahara H, Akira S, Kasuga M, Kadowaki T
    • Journal Title

      Cell Metabolism 13

      Pages: 401-412

    • Related Report
      2010 Self-evaluation Report
  • [Journal Article] Impaired insulin signaling in the endothelial cells reduces insulin-induced glucose uptake by the skeletal muscle.2011

    • Author(s)
      Kubota T, Kubota N, Kumagai H, Yamaguchi S, Kozono H, Takahashi T, Inoue M, Itoh S, Takamoto I, Sasako T, Kumagai K, Kawai T, Hashimoto S, Kobayashi T, Sato M, Tokuyama K, Nishimura S, Tsunoda M, Ide T, Murakami K, Yamazaki T, Ezaki O, Kawamura K, Masuda H, Moroi M, Sugi K, Oike Y, Shimokawa H, Yanagihara N, Tsutsui M, Terauchi Y, Tobe K, Nagai R, Kamata K, Inoue K, Kodama T, Ueki K, Kadowaki T
    • Journal Title

      Cell Metabolism 13

      Pages: 294-307

    • Related Report
      2010 Self-evaluation Report
  • [Journal Article] The other sweet face of XBP-1.2011

    • Author(s)
      Ueki K, Kadowaki T.
    • Journal Title

      Nature Med.

      Volume: 17 Pages: 246-248

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle.2011

    • Author(s)
      Kubota T, Kubota N, Kumagai H, Yamaguchi S, Kozono H, Takahashi T, Inoue M, Itch S, Takamoto I, Sasako T, Kumagai K, Kawai T, Hashimoto S, Kobayashi T, Sato M, Tokuyama K, Nishimura S, Tsunoda M, Ide T, Murakami K, Yamazaki T, Ezaki 0, Kawamura K, Masuda H, Moroi M, Sugi K, Oike Y, Shimokawa H, Yanagihara N, TsutsuiM, Terauchi Y, Tobe K, Nagai R, Kamata K, Inoue K, Kodama T, Ueki K, Kadowaki T.
    • Journal Title

      Cell Metab.

      Volume: 13 Pages: 294-307

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adiponectin receptor signaling : a new layer to the current model.2011

    • Author(s)
      Kadowaki T, Yamauchi T.
    • Journal Title

      Cell Metab.

      Volume: 13 Pages: 123-124

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adiponectin and AdipoR1 regulate PGC-1α and mitochondria by Ca2+ and AMPK/SIRT12010

    • Author(s)
      Iwabu, M., Yamauchi, T., Okada-Iwabu, M., Sato, K., Nakagawa, T., Funata, M., Yamaguchi, M., Namiki, S., Nakayama, R., Tabata, M., Ogata, H., Kubota, N.,Takamoto, I., Hayashi, YK., Yamauchi, N., Waki, H., Fukayama, M., Nishino, I., Tokuyama, K., Ueki, K., Oike, Y., Ishii, S., Hirose, K., Shimizu, T., Touhara, K., and Kadowaki, T
    • Journal Title

      Nature

      Volume: 464 Issue: 7293 Pages: 1313-1319

    • DOI

      10.1038/nature08991

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B2010

    • Author(s)
      Yamauchi T, Ham K, Iwabu M, Okada-Iwabu M, Kadowaki T
    • Journal Title

      Nature Genetics

      Volume: 42 Issue: 10 Pages: 864-868

    • DOI

      10.1038/ng.660

    • Related Report
      2012 Final Research Report
  • [Journal Article] Class IA phosphatidylinositol 3-kinase in pancreatic beta cells controls insulin secretion by multiple mechanisms2010

    • Author(s)
      Kaneko K, Ueki K, Kadowaki T
    • Journal Title

      Cell Metabolism

      Volume: 12 Issue: 6 Pages: 619-632

    • DOI

      10.1016/j.cmet.2010.11.005

    • Related Report
      2012 Final Research Report
  • [Journal Article] Dietary restriction; Standing up for sirtuins2010

    • Author(s)
      Baur JA, Kadowaki T
    • Journal Title

      Science

      Volume: 329 Issue: 5995 Pages: 1012-1015

    • DOI

      10.1126/science.329.5995.1012

    • Related Report
      2012 Final Research Report
  • [Journal Article] Macrophage-derived AIM is endocytosed into adipocytes and decreases lipid droplets via inhibition of fattty acid synthase activity2010

    • Author(s)
      Kurokawa J, Kubota N, Kadowaki T
    • Journal Title

      Cell Metabolism

      Volume: 11 Issue: 6 Pages: 479-492

    • DOI

      10.1016/j.cmet.2010.04.013

    • Related Report
      2012 Final Research Report
  • [Journal Article] A liver-derived secretory protein, selenoprotein P, causes insulin resistance2010

    • Author(s)
      Misu H, Kubota N, Kadowaki T
    • Journal Title

      Cell Metabolis

      Volume: 12 Pages: 483-495

    • NAID

      120002661942

    • Related Report
      2012 Final Research Report
  • [Journal Article] Long-term pancreas allograft survival in simultaneous pancreas-kidney transplantation by era: UN OS registry analysis2010

    • Author(s)
      Waki K, Terasaki PI, Kadowaki T
    • Journal Title

      Diabetes Care

      Volume: 33 Issue: 8 Pages: 1789-1791

    • DOI

      10.2337/dc09-2276

    • Related Report
      2012 Final Research Report
  • [Journal Article] Identification of KCNJ15 as a susceptibility gene in Asian patients with type 2 diabetes mellitus2010

    • Author(s)
      Okamoto K,, Kadowaki T
    • Journal Title

      Am.J.Hum. Genet

      Volume: 86 Issue: 1 Pages: 54-64

    • DOI

      10.1016/j.ajhg.2009.12.009

    • Related Report
      2012 Final Research Report
  • [Journal Article] Regulatory polymorphism in transcription factor KLF5 at the MEF2 element alters the response to angiotensin 11 and is associated with human hypertension2010

    • Author(s)
      Oishi Y, Hara K, Kadowaki T
    • Journal Title

      FASBB J

      Volume: 24 Issue: 6 Pages: 1780-1788

    • DOI

      10.1096/fj.09-146589

    • Related Report
      2012 Final Research Report
  • [Journal Article] The critical role of neutral cholesterol ester hydrolase 1 in cholesterol removal from human macrophages2010

    • Author(s)
      Igarashi M, Kadowaki T
    • Journal Title

      Circ. Res

      Volume: 107 Issue: 11 Pages: 1387

    • DOI

      10.1161/circresaha.110.226613

    • Related Report
      2012 Final Research Report
  • [Journal Article] Polyunsaturated fatty acids selectively suppress sterol regulatory element-binding protein-1 through proteolytic processing and autoloop regulatory circuit2010

    • Author(s)
      Takeuchi Y, Kadowaki T
    • Journal Title

      J. Biol. Chem.

      Volume: 285 Pages: 11681-11691

    • Related Report
      2012 Final Research Report
  • [Journal Article] Class IA phosphatidylinositol 3-kinase in pancreatic b cells controls insulin secretion by multiple mechanisms.2010

    • Author(s)
      Kaneko K, Ueki K, Takahashi N, Hashimoto S, Okamoto M, Awazawa M, Okazaki Y, Ohsugi M, Inabe K, Umehara T, Yoshida M, Kakei M, Kitamura T, Luo J, Kulkami RN, Kahn CR, Kasai H, Cantley LC, Kadowaki T
    • Journal Title

      Cell Metabolism 12

      Pages: 619-632

    • Related Report
      2010 Self-evaluation Report
  • [Journal Article] Adiponectin and AdipoR1 regulate PGC1・and mitochondria by Ca^<2+> and AMPK/SIRT1.2010

    • Author(s)
      Iwabu M, Yamauchi T, Okada-Iwabu M, Sato K, Nakagawa T, Funata M, Yamaguchi M, Namiki S, Nakayama R, Tabata M, Ogata H, Kubota N, Takamoto I, Hayashi YK, Yamauchi N, Waki H, Fukayama M, Nishino I, Tokuyama K, Ueki K, Oike Y, Ishii S, Hirose K, Shimizu T, Touhara K, Kadowaki T
    • Journal Title

      Nature 464

      Pages: 1313-1319

    • Related Report
      2010 Self-evaluation Report
  • [Journal Article] A liver-derived secretory protein, selenoprotein P, causes insulin resistance.2010

    • Author(s)
      Misu H, Takamura T, Takayama H, Hayashi H, Matsuzawa-Nagata N, Kurita S, Ishikura K, Ando H, Takeshita Y, Ota T, Sakurai M, Yamashita T, Mizukoshi E, Yamashita T, Honda M, Miyamoto K, Kubota T, Kubota N, Kadowaki T, Kim HJ, Lee IK, Minokoshi Y, Saito Y, Takahashi K, Yamada Y, Takakura N, Kaneko S.
    • Journal Title

      Cell Metab.

      Volume: 12 Pages: 483-4951

    • NAID

      120002661942

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Class IA phosphatidylinositol 3-kinase in pancreatic b cells controls insulin secretion by multiple mechanisms.2010

    • Author(s)
      Kaneko K, Ueki K, Takahashi N, Hashimoto S, Okamoto M, Awazawa M, Okazaki Y, Ohsugi M, Inabe K, Umehara T, Yoshida M, Kakei M, Kitamura T, Luo J, Kulkami RN, Kahn CR, Kasai H, Cantley LC, Kadowaki T
    • Journal Title

      Cell Metab.

      Volume: 12 Pages: 619-632

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBEZE2 and C2CD4A-C2CD4B.2010

    • Author(s)
      Yamauchi T, Hara K, Maeda S, Yasuda K, Takahashi A, Horikoshi M, Nakamura M, Fujito H, Grarup N, Cauchi S, Ng DPK, Ma RCW, Tsunoda T, Kubo M, Watada H, Maegawa H, Okada-lwabu M, Iwabu M, Shojima N, Shin HD, Andersen G, Witte DR, Jorgensen T, Lauritzen T, Sandbak A, Hansen T, Ohshige T, Omori S, Saito I, Kaku K, Hirose H, So WY, Beury D, Chan JCN, Park KS, Tai ES, Ito C, Tanaka Y, Kashiwag A, Kawamori R, Kasuga M, Frogue P, Pedersen O, Kamatani N, Nakamura Y, Kadowaki T
    • Journal Title

      Nature Genetics

      Volume: 42 Pages: 864-868

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dietary restriction; Standing up for sirtuins.2010

    • Author(s)
      Helfand, Imai S, Itoh H, Kadowaki T, Koya D, Leeuwenburgh C, Mcburney M, Nabeshima Y, Neri C, Oberdoerffer P, PestellRG, Rogina B, Sadoshima J, Sartorelli V, Serrano M, Sinclair DA, Steegborn C, Tatar M, Tissenbaum HA, Tong Q, Tsubota K, Vaquero A, Verdin E
    • Journal Title

      Science

      Volume: 329 Pages: 1012-1015

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Macrophage-derived AIM is endocytosed into adipocytes and decreases lipid droplets via inhibition of fattty acid synthase activity.2010

    • Author(s)
      Kurokawa J, Arai S, Nakashima K, Nagano H, Nishijima A, Miyata K, Ose R, Mori M, Kubota N, Kadowaki T, Oike Y, Koga H, Febbraio M, Iwanaga T, Miyazaki T
    • Journal Title

      Cell Metab.

      Volume: 11 Pages: 479-492

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adiponectin and AdipoRl regulate PGCI and mitochondria by Ca^<2+> and AMPK/SIRTI.2010

    • Author(s)
      Iwabu M, Yamauchi T, Okada-lwabu M, Sato K, Nakagawa T, Funata M, Pamaguchi M, Namiki S, Nakayama R, Tabata M, Ogata H, .Kubota N, Takamoto I, Hayashi YK, Yamauchi N, Waki H, Fukayama M, Nishino I, Tokuyama K, Ueki K, Oike Y, Ishii S, Hirose K, Shimizu T, Touhara K, Kadowaki T
    • Journal Title

      Nature

      Volume: 464 Pages: 1313-1319

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polyunsaturated fatty acids selectively suppress sterol regulatoryelement-binding protein-1 through proteolytic processing and autoloop regulatory circuit.2010

    • Author(s)
      Takeuchi Y, Yahagi N, Izumida Y, Nishi M, Kubota M, Teraoka Y, Yamamoto T, Matsuzaka T, Nakagawa Y, Sekiya M, Iizuka Y, Ohashi K, Osuga J, Gotoda T, Ishibashi S, Itaka K, Kataoka K, Nagai R, Yamada N, Kadowaki T, Shimano H
    • Journal Title

      J.Biol.Chem.

      Volume: 285 Pages: 11681-11691

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adiponectin recceptors are downregulated in human gastric cancer.2010

    • Author(s)
      Otani K, Kitayama J, Kamei T, Soma D, Miyato H, Yamauchi T, Kadowaki T, Nagawa H
    • Journal Title

      J Gastroenterol.

      Volume: 45 Pages: 918-927

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adiponectin and AdipoR1 regulate PGC-lalpha and mitochondria by Ca(2+) and AMPK/SIRT1.2010

    • Author(s)
      Iwabu M, Yamauchi T, Okada-Iwabu M, Sato K, Nakagawa T, Funata M, Yamaguchi M, Namiki S, Nakayama R, Tabata M, Ogata H, Kubota N, Takamoto I, Hayashi YK, Yamauchi N, waki H, Fukayama M, Nishino I, Tokuyama K, Ueki K, Oike Y, Ishii S, Hirose K, Shimizu T, Touhara K, Kadowaki T.
    • Journal Title

      Nature (published online Mar.31, 2010)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Decreased insulin secretion and accumulation of triglyceride in beta cells overexpressing a dominant-negative form of AMP-activated protein kinase.2010

    • Author(s)
      Okazaki Y, Eto K, Yamashita T, Okamoto M, Ohsugi M, Noda M, Terauchi Y, Ueki K, Kadowaki T
    • Journal Title

      Endocr J 57

      Pages: 141-52

    • NAID

      130004443612

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulatory polymorphism in transcription factor KLF5 at the MEF2 element alters the response to angiotensin II and is associaed with human hypertension.2010

    • Author(s)
      Oishi Y, Manabe I, Imai Y, Hara K, Horikoshi M, Fujiu K, Tanaka T, Aizawa T, Kadowaki T, Nagai R
    • Journal Title

      FASEB J (published online Jan.26, 2010)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of KCNJ15 as a susceptibility gene in Asian patients with type 2 diabetes mellitus.2010

    • Author(s)
      Okamoto K, Iwasaki N, Nishimura C, Doi K, Noiri E, Nakamura S, Tanizawa M, Ogata M, Fujimaki R, Grarup N, Pisinger C, Borch-Johnsen K, Lauritzen T, Sandbaek A, Hansen T, Yasuda K, Osawa H, Nanjo K, Kadowaki T, Kasuga M, Pedersen O, Fujita T, Kamatani N, Iwamoto Y, Tokunaga K
    • Journal Title

      Am J Hum Genet 86

      Pages: 54-64

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Colestilan monotherapy significantly improves glycaemic control and LDL cholesterol levels in patients with type 2 diabetes : a randomized double-blind placebo-controlled study.2010

    • Author(s)
      Kondo K, Kadowaki T
    • Journal Title

      Diabetes Obes Metab 12

      Pages: 246-251

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Peroxisome proliferator-activated receptor gamma agonist rosiglitazone increases the expression of very low density lipoprotein receptor gene in adipocytes2009

    • Author(s)
      Takazawa T, Yamauchi T, Iwabu M, Okada-Iwabu M, Ueki K, Kadowaki T
    • Journal Title

      J. Biol. Chem.

      Volume: 284 Pages: 30049-30057

    • Related Report
      2012 Final Research Report
  • [Journal Article] Rimonabant amelio- rates insulin resistance via both adipo- nectin-dependent and adiponectin -independent pathways2009

    • Author(s)
      atanabe T, Kubota N, Iwabu M, Yamauchi T, Ueki K, Kadowaki T
    • Journal Title

      J.Biol.Chem.

      Volume: 284 Issue: 3 Pages: 1803-1812

    • DOI

      10.1074/jbc.m807120200

    • Related Report
      2012 Final Research Report
  • [Journal Article] CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity2009

    • Author(s)
      Nishimura S, Hara K, Ueki K, Kadowaki T
    • Journal Title

      Nature Medicine

      Volume: 15 Issue: 8 Pages: 914-920

    • DOI

      10.1038/nm.1964

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ablation of neutral cholesterol easter hydrolase 1 accelerates atherosclerosis2009

    • Author(s)
      Sekiya M, Kadowaki T
    • Journal Title

      Cell Metabolism

      Volume: 10 Issue: 3 Pages: 219-228

    • DOI

      10.1016/j.cmet.2009.08.004

    • Related Report
      2012 Final Research Report
  • [Journal Article] Diabetes n Asia: epidemiology, risk factors, and pathophysiology2009

    • Author(s)
      Chan JC, Kadowaki T
    • Journal Title

      JAMA

      Volume: 301 Issue: 20 Pages: 2129-2140

    • DOI

      10.1001/jama.2009.726

    • Related Report
      2012 Final Research Report
  • [Journal Article] Critical role of class IA P13K for c-Rel expression in B lymphocytes2009

    • Author(s)
      Matsuda S, Kadowaki T
    • Journal Title

      Blood

      Volume: 113 Issue: 5 Pages: 1037-1044

    • DOI

      10.1182/blood-2008-06-163725

    • Related Report
      2012 Final Research Report
  • [Journal Article] Neuronal IGF-1 resistance reduces Ab-accumulation and protects against premature death in a model of Alzheimer's disease2009

    • Author(s)
      Freude S, Kubota N, Kadowaki T
    • Journal Title

      FASEB J.

      Volume: 23 Issue: 10 Pages: 3315-3324

    • DOI

      10.1096/fj.09-132043

    • Related Report
      2012 Final Research Report
  • [Journal Article] Replication study for the association of new meta-analysis-derived risk loci with sus- ceptibility to type 2 diabetes in 6,244 Japanese individuals2009

    • Author(s)
      Omori S, Kadowaki T
    • Journal Title

      Diabetologia

      Volume: 52 Issue: 8 Pages: 1554-1560

    • DOI

      10.1007/s00125-009-1397-5

    • Related Report
      2012 Final Research Report
  • [Journal Article] Glucose effects on beta-cell growth and survival require activation of insulin receptors and insulin receptor substrate 22009

    • Author(s)
      Assmann A, Kadowaki T
    • Journal Title

      Mol. Cell. Bio1.

      Volume: 29 Pages: 3219-3228

    • Related Report
      2012 Final Research Report
  • [Journal Article] The death effector domain-containing DEDD supports S6K1 activity via preventing Cdk1- dependent inhibitory phosphor- rylation2009

    • Author(s)
      Kurabe N, Kubota N, Kadowaki T
    • Journal Title

      J. Biol. Chem.

      Volume: 284 Pages: 5050-5055

    • Related Report
      2012 Final Research Report
  • [Journal Article] Impact of small molecule glucokinase activator on glucose metabolism, and beta cell function and mass2009

    • Author(s)
      Nakamura A, Kubota N, Kadowaki T
    • Journal Title

      Endocrinology

      Volume: 150 Pages: 1147-1154

    • Related Report
      2012 Final Research Report
  • [Journal Article] Targeting of neutral cholesterol ester hydrolase to the endoplasmic reticulum via its N-terminal sequence2009

    • Author(s)
      Igarashi M, Kadowaki T
    • Journal Title

      J. Lipid Res

      Volume: 51 Issue: 2 Pages: 274-285

    • DOI

      10.1194/jlr.m900201-jlr200

    • Related Report
      2012 Final Research Report
  • [Journal Article] Role of the liver in glucose homeostasis in P13-kinase p85{alpha}-deficient mice2009

    • Author(s)
      Aoki K, Kubota N, Kadowaki T
    • Journal Title

      Am. J. Physiol. Endocrinol. Metab

      Volume: 296 Issue: 4 Pages: E842-E853

    • DOI

      10.1152/ajpendo.90528.2008

    • Related Report
      2012 Final Research Report
  • [Journal Article] Alpha2-AMPK activity is not essential for an increase in fatty acid oxi- dation during low-intensity exercise2009

    • Author(s)
      Miura S, Kubota N, Kadowaki T, Ezaki O, et al.
    • Journal Title

      Am. J. Physiol. Endocrinol. Metab.

      Volume: 296 Issue: 1 Pages: E47-E55

    • DOI

      10.1152/ajpendo.90690.2008

    • Related Report
      2012 Final Research Report
  • [Journal Article] How controlling of hypertension might matter-Beyond blood pressure-2009

    • Author(s)
      Hara K, Kadowaki T
    • Journal Title

      Circulation J 73

      Pages: 2208-2209

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Peroxisome proliferator-activated receptor gamma agonist rosiglitazone increases the expression of very low density lipoprotein receptor gene in adipocytes.2009

    • Author(s)
      Takazawa T, Yamauchi T, Tsuchida A, Takata M, Hada Y, Iwabu M, Okada-Iwabu M, Ueki K, Kadowaki T
    • Journal Title

      J Biol Chem 30

      Pages: 30049-30057

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity.2009

    • Author(s)
      Nishimura S, Manabe I, Nagasaki M, Eto K, Yamashita H, Ohsugi M, Otsu M, Hara K, Ueki K, Sugiura S, Yoshimura K, Kadowaki T, Nagai R
    • Journal Title

      Nat Med 15

      Pages: 914-920

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reconsideration of insulin signals induced by improved laboratory animal diets, Japanese and American diets, in IRS-2 deficcient mice.2009

    • Author(s)
      Hashimoto H, Arai T, Mori A, Kawai K, Hikishima K, Ohnishi Y, Eto T, Ito M, Hioki K, Suzuki R, Ohsugi M, Saito M, Ueyama Y, Okano H, Yamauchi T, Kubota N, Ueki K, Tobe K, Tamaoki N, Kadowaki T, Kosaka K
    • Journal Title

      Exp Clin Endocrinol Diabetes 117

      Pages: 577-86

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy and safety of insulin glulisine in Japanese patients with type l diadbetes mellitus.2009

    • Author(s)
      Kawamori R, Kadowaki T, Ishii H, Iwasaki M, Iwamoto Y
    • Journal Title

      Diabetes Obes Metab 11

      Pages: 891-899

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of insulin glulisine sa mono- or add-on therapy in patients with type 2 diabetes mellitus.2009

    • Author(s)
      Kawamori R, Iwamoto Y, Kadowaki T, Iwasaki M, Kim SW, Woo JT, Baik SH, Yoon KH
    • Journal Title

      Diabetes Obes Metab 11

      Pages: 900-909

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Successful desensitization by glargine administration in patient with insulin allergy : a case report.2009

    • Author(s)
      Hara M, Izumida Y, Sato N, Ohashi K, Osuga JI, Tobe K, Tsukamoto K, Kadowaki T
    • Journal Title

      Diabetes Res Clin Pract 84

      Pages: 48-49

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adiponectin suppresses hepatic SREBP1c expression in an AdipoR1/LKB1/AMPK dependent pathway.2009

    • Author(s)
      Awazawa M, Ueki K, Inabe K, Yamauchi T, Kanako K, Okazaki Y, Bardeesy N, Ohnishi S, Nagai R, Kadowaki T
    • Journal Title

      Biochem Biophys Res Commun 382

      Pages: 51-56

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rimonabant ameliorates insulin resistance via both adiponectin-dependent and asiponectin-independent pathways2009

    • Author(s)
      Watanabe T, Kubota N, Ohsugi M, Kubota T, Takammoto I, Iwabu M, Awazawa M, Katsuyama H, Hasegawa C, Tokuyama K, Moroi M, Sugi K, Ymauchi T, Noda T, Nagai R, Terauchi Y, Tobe K, Ueki K, Kadowaki T
    • Journal Title

      J Biol Chem 284

      Pages: 1803-1812

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of the liver in glucose homeostasis in PI 3-kinase p85{alpha}-deficient mice.2009

    • Author(s)
      Aoki K, Matsui J, Kubota N, Nakajima H, Iwamoto K, Takamoto I, Tsuji Y, Iwamoto K, Takamoto I, Tsuji Y, Ohno A, Mori S, Tokuyama K, Murakami K, asano T, Aizawa S, Tobe K, Kadowaki T, Terauchi Y
    • Journal Title

      Am J Physiol Endocrinol Metab 296

      Pages: 842-853

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The death effector domain-containing DEDD supports S6K1 activity via preventing Cdk1-dependent inhibitory phosphorylation2009

    • Author(s)
      Kurabe N, Arai S, Nishijima A, Kubota N, Suizu F, Mori M, Kurokawa J, Kondo-Miyazaki M, Ide T, Murakami K, Miyake K, Ueki K, Koga H, Yatomi Y, Tashiro F, Noguchi M, Kadowaki T, Miyazaki T.
    • Journal Title

      J Biol Chem 284

      Pages: 5050-5055

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of small-molecule glucokinase activator on glucose metabolism and beta-cell mass2009

    • Author(s)
      Nakamura A, Terauchi Y, Ohyama S, Kubota J, shimazaki H, Nambu T, Takamoto I, Kubota N, Eiki J, Yoshioka N, Kadowaki T, Koike T
    • Journal Title

      Endocrinology 150

      Pages: 1147-1154

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dynamic functional relay between insulin receptor substrate-1 and -2 in hepatic insulin signaling during fasting and feeding2008

    • Author(s)
      Kubota N, Ueki K, Kadowaki T
    • Journal Title

      Cell Metabolism

      Volume: 8 Issue: 1 Pages: 49-64

    • DOI

      10.1016/j.cmet.2008.05.007

    • Related Report
      2012 Final Research Report
  • [Journal Article] Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus2008

    • Author(s)
      Yasuda K, Hara K, Kadowaki T
    • Journal Title

      Nature Genetics

      Volume: 40 Issue: 9 Pages: 1092-1097

    • DOI

      10.1038/ng.207

    • Related Report
      2012 Final Research Report
  • [Journal Article] SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations2008

    • Author(s)
      Unoki H, Hara K, Kadowaki T
    • Journal Title

      Nature Genetics

      Volume: 40 Issue: 9 Pages: 1098-1102

    • DOI

      10.1038/ng.208

    • Related Report
      2012 Final Research Report
  • [Journal Article] Adiponectin induces insulin secretion in vitro and in vivo at a low glucose concentration2008

    • Author(s)
      Okamoto M, Kubota N, Kadowaki T
    • Journal Title

      Diabetologia

      Volume: 51 Issue: 5 Pages: 827-835

    • DOI

      10.1007/s00125-008-0944-9

    • Related Report
      2012 Final Research Report
  • [Journal Article] SUMOylation of Kruppel-like transcription factor 5 acts as a molecular switch in transcriptional programs of lipid metabolism involving PPAR-delta.2008

    • Author(s)
      Oishi Y, Kubota N, Kadowaki T
    • Journal Title

      Nature Medicine

      Volume: 14 Issue: 6 Pages: 656-666

    • DOI

      10.1038/nm1756

    • Related Report
      2012 Final Research Report
  • [Journal Article] In vivo imaging in mice reveals local cell dynamics and inflammation in obese adipose tissue2008

    • Author(s)
      Nishimura S, Kadowaki T
    • Journal Title

      J.Clin.Invest.

      Volume: 118 Pages: 710-721

    • Related Report
      2012 Final Research Report
  • [Journal Article] KLF6 in Nonalcoholic Fatty Liver Disease: Role of Fibrogenesis and Carcinogenesis2008

    • Author(s)
      Watanabe K, Kadowaki T
    • Journal Title

      Gastroenterology

      Volume: 135 Issue: 1 Pages: 309

    • DOI

      10.1053/j.gastro.2008.06.014

    • Related Report
      2012 Final Research Report
  • [Journal Article] Adiponectin suppresses colorectal carcinogenesis under the high-fat diet condition2008

    • Author(s)
      Fujisawa T, Kubota N, Yamauchi T, Kadowaki T
    • Journal Title

      Gut

      Volume: 57 Issue: 11 Pages: 1531-1538

    • DOI

      10.1136/gut.2008.159293

    • Related Report
      2012 Final Research Report
  • [Journal Article] Glimepiride-induced bronchial asthma2008

    • Author(s)
      Tsukamoto K, Kadowaki T
    • Journal Title

      Diabetes Care

      Volume: 31 Issue: 12 Pages: e91-e91

    • DOI

      10.2337/dc08-1536

    • Related Report
      2012 Final Research Report
  • [Journal Article] Identification of neutral cholesterol ester hydrolase, a key enzyme removing cholesterol from macrophages2008

    • Author(s)
      Okazaki H, Kadowaki T
    • Journal Title

      J.Biol. Chem.

      Volume: 283 Issue: 48 Pages: 33357-33364

    • DOI

      10.1074/jbc.m802686200

    • Related Report
      2012 Final Research Report
  • [Journal Article] Dynamic functional relay between insulin receptor substrate-1 and -2 in hepatic insulin signaling during fasting and feeding.2008

    • Author(s)
      Kubota N, Kubota T, Itoh S, Kumagai H, Kozono H, Takamoto I, Mineyama T, Ogata H, Tokuyama K, Ohsugi M, Sasako T, Moroi M, Sugi K, Kakuta S, Iwakura Y, Noda T, Ohnishi S, Nagai R, Tobe K, Terauchi Y, Ueki K, Kadowaki T
    • Journal Title

      Cell Metabolism 8

      Pages: 49-64

    • Related Report
      2010 Self-evaluation Report
  • [Journal Article] Adiponectin suppresses colorectal carcinogenesis under the high-fat diet condition2008

    • Author(s)
      Fujisawa T, Endo H, Tomimoto A, Sugiyama M, Takahashi H, Saito S, Inamori M,nakajima N, Watanabe M, Kubota N, Yamauchi T, Kadowaki T, Wada K, Nakagama H, Nakajima A.
    • Journal Title

      Gut 57

      Pages: 1531-1538

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 5-Hydroxytryptamine 2A receptor signaling cascade modulates adiponectin and plasminogen activator inhibitor 1 expression in adipose tissue.2008

    • Author(s)
      Uchida-Kitajima S, Ymauchi T, Takashina Y,Okada-Iwabu M, Iwabu M, Ueki K,Kadowaki T
    • Journal Title

      FEBS Lett 582

      Pages: 3037-3044

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An effecient reproductive method for Irs2-/- mice with C57BL/6JJcl genetic background2008

    • Author(s)
      Hashimoto H, Eto T, Kamisako t, Hoya N, Hatakeyama T, Arai T, Yokosuka M, Ohnishi Y, Ito M, Hioki K, Suzuki R, Osugi M, Saito M, Ueyama Y, Ymauchi T, Kubota N, Tobe K, Kadowaki T, Tamaoki N, Nomura T, Kosaka K.
    • Journal Title

      Exp Anim 57

      Pages: 407-411

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fulminant type 1 diabetes mellitus observed in insulin receptor substrate 2 deficient mice2008

    • Author(s)
      Arai T, Hashimoto H, Kawai K, Mori A, Ohnishi Y, Hioki K, Ito M, Sito M, Ueyama Y, Ohsugi M, Suzuki R, Kubota N, Yamauchi T, Tobe K, Kadowaki T, Kosaka K
    • Journal Title

      Clin Exp Med 8

      Pages: 93-99

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crucial role of insulin receptor substrate-2 in compensatory beta-cell hyperplasia in response to high fat diet-induced insulin resistance2008

    • Author(s)
      Takamoto I, terauchi Y, Kubota N, Ohsugi M, ueki K, Kadowaki T
    • Journal Title

      Diabetes Obes Metab 10

      Pages: 147-156

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dynamic functional relay between insulin receptor substrate 1 and 2 in hepatic insulin signaling during fasting and feeding2008

    • Author(s)
      Kubota N, Kubota T, Itoh S, Kumagai H, Kozono H, Takamoto I, Mineyama T, Ogata H, Tokuyama K, Ohsugi M, Sasako T, Moroi M, Sugi K, Kakuta S, Iwakura Y, Noda T, Ohnishi S, Ngai R, Tobe K, Terauchi Y, Ueki K, Kadowaki T
    • Journal Title

      Cell Metab 8

      Pages: 49-64

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of increased PPARgamma activity in adipocytes in vivo on adiposity, insulin sensitivity and the effects of rosiglitazone treatment2008

    • Author(s)
      Takasawa K, Kubota N, Terauchi Y, Kadowaki T.
    • Journal Title

      Endocr J 55

      Pages: 767-776

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] SUMOylation ofKruppel-like transcription factor 5 acts as a molecular switch in transcriptional programs of lipid metabolism involving PPAR-delta2008

    • Author(s)
      Oishi Y, Manabe I, Tobe K, Ohsugi M, Kubota T, Fujiu K, Maemura K, KUbota N, Kadowaki T, Nagai R
    • Journal Title

      Nat Med 14

      Pages: 656-666

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Peroxisome proliferator-activated receptor gamma (PPARgamma) suppresses colonic epithelial cell turnover and colon carcinogenesis through inhibition of the beta-catein/T cell factor (TCF) pathway.2008

    • Author(s)
      Fujisawa T, Nkajima A, Fujisawa N, Tkahashi H, Ikeda I, Tomimoto A, Yonemitsu K, Nkajima N, Kudo C, Wada K, Kubota N, Terauchi Y, Kadowaki T, Nkagama H, Blumberg RS
    • Journal Title

      J Pharmacol Sci 106

      Pages: 627-638

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adiponectin induces insulin secretion in vitro and in vivo at a low glucose concentration2008

    • Author(s)
      Wakui M, Ngai R, Noda M, Nagamatsu S, Kadoaki T
    • Journal Title

      Diabetologia 51

      Pages: 827-835

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of adenovirus 36 infection with obesity and metabolic markers in humans: a meta-analysis of observational studies

    • Author(s)
      Yamada T, Hara K, Kadowaki T
    • Journal Title

      PLoS One

      Volume: 7

    • Related Report
      2012 Final Research Report
  • [Presentation] AdipoRs activation increases Ca2+ and AMPK/SIRT/PGC-1, thereby regulating metabolic stress and mitochondria, leading to anti-aging and amelioration of diseases of aging2012

    • Author(s)
      Takashi Kadowaki
    • Organizer
      KEYSTONE SYMPOSIA: Aging and Diseases of Aging
    • Place of Presentation
      TOKYO
    • Year and Date
      2012-10-26
    • Related Report
      2012 Final Research Report
  • [Presentation] Adiponectin and adiponectin receptors in insulin resistance and type 2 diabetes2011

    • Author(s)
      門脇孝
    • Organizer
      The World Diabetes Congress
    • Place of Presentation
      Dubai, UAE(招待講演)
    • Year and Date
      2011-12-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] Role of PI3 kinase in type 2 diabetes2011

    • Author(s)
      門脇孝
    • Organizer
      New Aspect of Phospholipid Biology and Medical
    • Place of Presentation
      福岡県福岡市(招待講演)
    • Year and Date
      2011-11-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] 2型糖尿病の分子機構と治療戦略2011

    • Author(s)
      門脇孝
    • Organizer
      第108回日本内科学会講演会
    • Place of Presentation
      神奈川県横浜市(招待講演)
    • Year and Date
      2011-11-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] 2型糖尿病の分子機構解明における遺伝子操作動物の意義2011

    • Author(s)
      門脇孝
    • Organizer
      第25回日本糖尿病・肥満動物学会年次学術集会
    • Place of Presentation
      東京
    • Year and Date
      2011-11-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] 2型糖尿病の体質に関する研究-遺伝素因の解明とアディポネクチン作用低下の意義2011

    • Author(s)
      門脇孝
    • Organizer
      第61回日本体質医学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-10-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] 我が国におけるウエスト周囲径・メタボリックシンドロームに関するエビデンス2011

    • Author(s)
      門脇孝
    • Organizer
      第32回日本肥満学会
    • Place of Presentation
      兵庫県淡路市(招待講演)
    • Year and Date
      2011-09-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] 1st International Conference on Immuno Metabolism2011

    • Author(s)
      門脇孝
    • Organizer
      Adiponectin and adiponectin receptors in insulin resistance and type2 diabetes
    • Place of Presentation
      Crete, Greese(招待講演)
    • Year and Date
      2011-09-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] Insulin and adiponectin pathways in type2 diabetes2011

    • Author(s)
      門脇孝
    • Organizer
      Dundee Diabetes Research Centre Annual Lecture Seminar
    • Place of Presentation
      Dundee, Scotland(招待講演)
    • Year and Date
      2011-09-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Adiponectin action through AMPK2011

    • Author(s)
      Takashi Kadowaki
    • Organizer
      American Diabetes Association 71st Scientific Sessions
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2011-06-26
    • Related Report
      2012 Final Research Report
  • [Presentation] Adiponectin action through AMPK2011

    • Author(s)
      門脇孝
    • Organizer
      American Diabetes Association 71st Scientific Sessions
    • Place of Presentation
      San Diego, USA(招待講演)
    • Year and Date
      2011-06-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] Adiponectin & Adipose Tissue2011

    • Author(s)
      門脇孝
    • Organizer
      Endo 2011
    • Place of Presentation
      Boston, USA(招待講演)
    • Year and Date
      2011-06-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] Multiple aspects of molecular mechanism of insulin resistance in type2 diabetes2011

    • Author(s)
      Takashi Kadowaki
    • Organizer
      76th Cold Spring Harbor Laboratory Symposium
    • Place of Presentation
      Cold Spring Harbor, USA
    • Year and Date
      2011-06-02
    • Related Report
      2012 Final Research Report
  • [Presentation] Multiple aspects of molecular mechanism of insulin resistance in type 2 diabetes2011

    • Author(s)
      門脇孝
    • Organizer
      76th Cold Spring Harbor Laboratory Symposium
    • Place of Presentation
      Cold Spring Harbor, USA(招待講演)
    • Year and Date
      2011-06-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] 生活習慣病からみた抗加齢医学2011

    • Author(s)
      門脇孝
    • Organizer
      第11回日本抗加齢医学会総会
    • Place of Presentation
      京都府京都市(招待講演)
    • Year and Date
      2011-05-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] 災害時の糖尿病医療-日本糖尿病学会の対応と今後の対応2011

    • Author(s)
      門脇孝
    • Organizer
      第54回日本糖尿病学会年次学術集会緊急シンポジウム「災害時の糖尿病医療」
    • Place of Presentation
      北海道札幌市
    • Year and Date
      2011-05-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] 糖尿病と病理Pathological aspects of diabetes2011

    • Author(s)
      門脇孝
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      神奈川県横浜市(招待講演)
    • Year and Date
      2011-04-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca2+ signalling and AMPK/SIRT1 like exercise.2010

    • Author(s)
      Yamauchi T, Iwabu M, Okada-Iwabu M, Ueki K, Kadowaki T
    • Organizer
      46^<th> Annual Meeting of the European Association for the Study of Diabetes.
    • Place of Presentation
      Stockholm
    • Year and Date
      2010-09-22
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Adiponectin and AdipoRl regulate PGC-lalpha and mitochondria by Ca^<2+> signalling and AMPK/SIRTl like exercise.2010

    • Author(s)
      Yamauchi T. Iwabu M. Okada-Iwabu M, Ueki K, Kadowaki T
    • Organizer
      6^<th>Annual Meeting of the European Association for the Study of Diabetes.
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      2010-09-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] Role of adiponectin/AdipoR1 in skeletal muscle in mitochondrial biogenesis, exercise endurance and insulin sensitivity.2010

    • Author(s)
      Kadowaki T
    • Organizer
      The 14th International Congress of Endocrinology(ICE2010)
    • Place of Presentation
      京都
    • Year and Date
      2010-03-28
    • Related Report
      2010 Self-evaluation Report 2009 Annual Research Report
  • [Presentation] Role of Adiponectin and Adiponectin Receptors in Insulin Resistance2010

    • Author(s)
      門脇孝
    • Organizer
      The official Satellite Symposium of the 14^<th> ICE2010
    • Place of Presentation
      東京
    • Year and Date
      2010-03-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] Adiponectin : a key Regulator of Diabetes and Cancer2010

    • Author(s)
      門脇孝
    • Organizer
      A symposium at Institute Pasteur Korea
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2010-02-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] 生活習慣病の成因・治療のエビデンスと管理栄養士の使命2010

    • Author(s)
      門脇孝
    • Organizer
      第13回日本病態栄養学会
    • Place of Presentation
      京都
    • Year and Date
      2010-01-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] Inflammation and the Metabolic Syndrome2009

    • Author(s)
      門脇孝
    • Organizer
      Asia Pacific Conference on the Metabolic Syndrome
    • Place of Presentation
      Melbourne, Australia
    • Year and Date
      2009-11-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] アディポサイトカインと心血管内分泌代謝学2009

    • Author(s)
      門脇孝
    • Organizer
      第13回日本心血管内分泌代謝学会学術総会
    • Place of Presentation
      埼玉
    • Year and Date
      2009-10-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] Adipocyte.2009

    • Author(s)
      Kadowaki T
    • Organizer
      20^<th> World Diabetes Congress(IDF)
    • Place of Presentation
      Montreal
    • Year and Date
      2009-10-20
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Adipocyte2009

    • Author(s)
      門脇孝
    • Organizer
      20^<th> World Diabetes Congress(IDF)
    • Place of Presentation
      Montreal, Canada
    • Year and Date
      2009-10-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] 糖尿病ガイドライン:治療の面から2009

    • Author(s)
      門脇孝
    • Organizer
      第57回日本心臓学会学術集会
    • Place of Presentation
      北海道
    • Year and Date
      2009-09-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] 2型糖尿病の体質とそれをふまえた治療戦略2009

    • Author(s)
      門脇孝
    • Organizer
      日本体質医学会
    • Place of Presentation
      東京
    • Year and Date
      2009-07-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] 肥満とアディポカイン-メタボリックシンドロームを理解する-2009

    • Author(s)
      門脇孝
    • Organizer
      第2回日本肥満症治療学会
    • Place of Presentation
      東京
    • Year and Date
      2009-07-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] The Rule of IRS2 in Hepatic Insulin Sensitivity.2009

    • Author(s)
      Kadowaki T
    • Organizer
      American Diabetes Association 69^<th> Scientific Sessions
    • Place of Presentation
      Louisiana
    • Year and Date
      2009-06-06
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] The Rule of IRS2 in Hepatic Insulin Sensitivuty2009

    • Author(s)
      門脇孝
    • Organizer
      American Diabetes Association 69^<th> Scientific Sessions
    • Place of Presentation
      Louisiana, U.S.A.
    • Year and Date
      2009-06-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] 糖尿病患者の新たなる治療ステージ2009

    • Author(s)
      門脇孝
    • Organizer
      第52回日本糖尿病学会年次学術集会総会
    • Place of Presentation
      大阪
    • Year and Date
      2009-05-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] 発生工学的研究を用いた糖尿病創薬研究の戦略2009

    • Author(s)
      門脇孝
    • Organizer
      第56回日本実験生物学会総会
    • Place of Presentation
      埼玉
    • Year and Date
      2009-05-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] 糖尿病・メタボリックシンドロームの病態と治療戦略-最近の知見-2009

    • Author(s)
      門脇孝
    • Organizer
      第46回日本臨床分子医学会学術総会
    • Place of Presentation
      東京
    • Year and Date
      2009-04-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] Epidemic of type 2 diabetes in Japan-Its causes and preventive strategies.2009

    • Author(s)
      Kadowaki T
    • Organizer
      3^<rd> International Congress on Prediabetes and the Metabolic Syndrome.
    • Place of Presentation
      Nice
    • Year and Date
      2009-04-02
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Epidemic of type 2 diabetes in Japan-Its causes and preventive strategies2009

    • Author(s)
      門脇孝
    • Organizer
      3^(rd) International Congress on Pre diabetes and the Metabolic Syndrome
    • Place of Presentation
      Nice, France
    • Year and Date
      2009-04-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] 遺伝子操作動物を用いた糖尿病研究の戦略2009

    • Author(s)
      門脇孝
    • Organizer
      第23回日本糖尿病・肥満動物学会年次学術集会
    • Place of Presentation
      岡山
    • Year and Date
      2009-02-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] AMPK in sickness and health from molecule to man2008

    • Author(s)
      門脇孝
    • Organizer
      FASEB SUMMER RESEARCH CONFERENCES
    • Place of Presentation
      Copenhagen
    • Year and Date
      2008-08-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] メタボリック症候群とアディボカイン2008

    • Author(s)
      門脇孝
    • Organizer
      第51回日本腎臓学会学術総会
    • Place of Presentation
      福岡
    • Year and Date
      2008-06-01
    • Related Report
      2008 Annual Research Report
  • [Presentation] 2型の糖尿病の成因を追い求める旅」-真理への希求-2008

    • Author(s)
      門脇孝
    • Organizer
      第51回日本糖尿病学会年次学術集会
    • Place of Presentation
      東京
    • Year and Date
      2008-05-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] Adiponectin and its receptors in insulin resistance, diabetes and metabolic syndrome and obesity2008

    • Author(s)
      門脇孝
    • Organizer
      10^<th> European Congress of Endocrinology
    • Place of Presentation
      berlin
    • Year and Date
      2008-05-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] 2型糖尿病の分子機構-インスリンとアディポネクチン作用を中心に

    • Author(s)
      門脇 孝
    • Organizer
      第85回日本内分泌学会学術総会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 糖尿病と炎症

    • Author(s)
      門脇 孝
    • Organizer
      第77回日本インターフェロン・サイトカイン学会学術集会
    • Place of Presentation
      神戸
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 糖尿病と炎症

    • Author(s)
      門脇 孝
    • Organizer
      第33回日本炎症・再生医学会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Molecular Mechanism of Type 2 Diabetes

    • Author(s)
      門脇 孝
    • Organizer
      ISPAD Science School for Physicians 2012 in Kyoto Special Lecture
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] アディポネクチンを中心とした抗加齢戦略

    • Author(s)
      門脇 孝
    • Organizer
      日本抗加齢医学会主催エデュケーショナルセミナー
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 糖尿病と炎症-歯周病を含めて

    • Author(s)
      門脇 孝
    • Organizer
      第55回秋季日本歯周病学会学術大会
    • Place of Presentation
      茨城
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 2型糖尿病の分子基盤-真理の探究

    • Author(s)
      門脇 孝
    • Organizer
      第8回臨床分子医学研究会
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 若手医師のための糖尿病講義

    • Author(s)
      門脇 孝
    • Organizer
      第47回糖尿病学の進歩
    • Place of Presentation
      四日市
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Molecular Mechanism of Type 2 Diabetes

    • Author(s)
      Takashi Kadowaki
    • Organizer
      2012 Kroc Lecture
    • Place of Presentation
      Chicago, USA
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Molecular Mechanism of Type 2 Diabetes

    • Author(s)
      Takashi Kadowaki
    • Organizer
      Lecture in the Feinberg School of Medicine of Northwestern University
    • Place of Presentation
      Chicago, USA
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Tofogliflozin, a Novel and Selective SGLT2 Inhibitor Improves Glycemic Control and Lowers Body Weight in Patients with Type 2 Diabetes Mellitus Inadequately Controlled on Stable Metformin or Diet and Exercise Alone

    • Author(s)
      Takashi Kadowaki
    • Organizer
      American Diabetes Association 72st Scientific Sessions
    • Place of Presentation
      Philadelphia, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] AdipoRs Activation Reduced Ectopic Fat Accumulation and Inflammation, Leading to Improved Glucose/ Lipid Metabolism

    • Author(s)
      Takashi Kadowaki
    • Organizer
      The 64th FUJIHARA SEMINAR International Symposium on Adiponectin Biology and Medicine
    • Place of Presentation
      Tomakomai, Japan
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] AdipoRs activation increases Ca2+and AMPK/SIRT/PGC-1, thereby regulating metabolic stress and mitochondria, leading to anti-aging and amelioration of diseases of aging

    • Author(s)
      Takashi Kadowaki
    • Organizer
      KEYSTONE SYMPOSIA: Aging and Diseases of Aging
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Molecular Mechanism of Insulin Resistance in Type 2 Diabetes

    • Author(s)
      Takashi Kadowaki
    • Organizer
      9th IDF-WPR Congress
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] A novel and Selective SGLT2 inhibitor, tofogliflozin improves glycemic control and lowers body weight in patients with type 2 diabetes mellitus

    • Author(s)
      Takashi Kadowaki
    • Organizer
      9th IDF-WPR Congress
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2012 Annual Research Report
  • [Book] 最新臨床糖尿病学上-糖尿病学の最新動向- I.総論 日本糖尿病学会のアクションプラン2010(DREAMS)2012

    • Author(s)
      門脇 孝
    • Total Pages
      9
    • Publisher
      日本臨牀
    • Related Report
      2012 Annual Research Report
  • [Book] 最新臨床糖尿病学上-糖尿病学の最新動向- IV.糖尿病の疾患概念・病型分類・成因 2型糖尿病 2型糖尿病の疾患概念2012

    • Author(s)
      門脇 孝
    • Total Pages
      8
    • Publisher
      日本臨牀
    • Related Report
      2012 Annual Research Report
  • [Book] HbA1c国際標準化-日常臨床での運用の実際と啓発の重要性2012

    • Author(s)
      門脇 孝
    • Total Pages
      13
    • Publisher
      Diabetes Journal
    • Related Report
      2012 Annual Research Report
  • [Book] アディポネクチンとその受容体-抗生活習慣病ホルモンの全貌(単行本)2008

    • Author(s)
      門脇孝
    • Publisher
      フジメディカル出版
    • Related Report
      2012 Final Research Report
  • [Book] あなたがメタボになる理由(単行本)2008

    • Author(s)
      門脇孝
    • Publisher
      PHP研究所
    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://dm301k.umin.jp/

    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://dm301k.umin.jp/

    • Related Report
      2010 Self-evaluation Report
  • [Patent(Industrial Property Rights)] 擬似運動療法のための医薬2011

    • Inventor(s)
      門脇孝、山内敏正、他2名
    • Industrial Property Rights Holder
      (株)東京大学TLO
    • Filing Date
      2011-03-15
    • Related Report
      2012 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] アディポネクチン受容体及びそれをコードする遺伝子2010

    • Inventor(s)
      門脇孝、山内敏正、他2名
    • Industrial Property Rights Holder
      東京大学TLO、日産化学工業(株)
    • Acquisition Date
      2010-01-22
    • Related Report
      2012 Final Research Report

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Published: 2008-04-01   Modified: 2023-03-16  

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