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2012 Fiscal Year Final Research Report

Integrated elucidation of metabolic pathway in the physiology and pathology

Research Project

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Project/Area Number 20229008
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Metabolomics
Research InstitutionThe University of Tokyo

Principal Investigator

KADOWAKI Takashi  東京大学, 医学部附属病院, 教授 (30185889)

Co-Investigator(Kenkyū-buntansha) UEKI Kohjiro  東京大学, 医学部附属病院, 准教授 (00396714)
YAMAUCHI Toshimasa  東京大学, 医学部附属病院, 講師 (40372370)
Co-Investigator(Renkei-kenkyūsha) HARA Kazuo  東京大学, 医学部附属病院, 特任准教授 (50359600)
KUBOTA Naoto  東京大学, 医学部附属病院, 特任准教授 (50396719)
Project Period (FY) 2008 – 2012
Keywordsアディポネクチン / インスリン / AdipoR / 糖代謝 / 脂質代謝
Research Abstract

An integrated understanding of metabolic regulation and its disruption is essential in elucidating the pathophysiology of diabetes and the metabolic syndrome as well as in developing therapeutic modalities for these conditions. In this connection, we contributed to generating scientific evidence that constitutes a basis for the development of anti妖iabetic therapies targeted at the regulation of insulin and/or adiponectin action as well as to the discovery of candidate anti-diabetic compounds, by elucidating the mechanisms involved in the inter-organ cross-walks in the regulation of insulin and/or adiponectin action.

  • Research Products

    (73 results)

All 2013 2012 2011 2010 2009 2008 Other

All Journal Article (65 results) Presentation (3 results) Book (2 results) Remarks (1 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 1 results)

  • [Journal Article] Adiponectin receptor as a key player in healthy longevity and obesity-related diseases2013

    • Author(s)
      Yamauchi T, Kadowaki T.
    • Journal Title

      Cell Metab

      Volume: 17 Pages: 185-196

    • DOI

      DOI:10.1016/j.cmet. 2013. 01.001.

  • [Journal Article] Baseline predictive factors for glycemic control in Japanese type 2 diabetes patients treated with insulin glargine plus oral antidiabetic drugs: ALOHA study subanalysis2013

    • Author(s)
      Kadowaki T, Ohtani T, Odawara M.
    • Journal Title

      Diabetol Int

      Volume: 4 Pages: 16-22

    • DOI

      DOI:10.1007/s13340-012-087-6

  • [Journal Article] Efficacy, safety and dose-desponse relationship of teneligliptin, a dipeptidyl peptidase-4 inhibitor, in Japanese patients with type 2 diabetes mellitus2013

    • Author(s)
      Kadowaki T, Kondo K.
    • Journal Title

      Diabetes Obes Metab

    • DOI

      DO1:10.1111/dom.12092

  • [Journal Article] Genome-wide Association Study Identifies a Novel Locus Contributing to Type 2 Diabetes Susceptibility in Sikhs of Punjabi Origin From India2013

    • Author(s)
      Saxena R, Yamauchi T, Hara K Saxena R, Yamauchi T, Hara K DIAGRAM MuTHER; TGEN, Kadowaki T
    • Journal Title

      Diabetes

      Volume: 62 Pages: 1746-1755

    • DOI

      DOI:10.2337/db 12-1077

  • [Journal Article] Diabetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium, Nakamura Y, Kadowaki T: A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations2012

    • Author(s)
      Imamura M,1,Yamauchi T, Hara K, Okada-Iwabu M, Iwabu M
    • Journal Title

      Human Molecular Genatics

      Volume: 21 Pages: 3042-3049

    • DOI

      D0I:10.1093/hmo/r1r1c113.

  • [Journal Article] Expression-based genome-gide association study links CD44 in adipose tissue with type 2 diabetes2012

    • Author(s)
      Kodama K, Hara K, Kadowaki T, Butte AJ
    • Journal Title

      Proc. Natl. Acad. Sci. USA

      Volume: 109 Pages: 7049-7054

    • DOI

      DOI:10.1073/pnas.1114513109

  • [Journal Article] Cntrol of beta cell function and proliferation in mice stimulated by small-molecule glucokinase activator under various conditions2012

    • Author(s)
      Nakamura A, Kubota N, Kadowaki T
    • Journal Title

      Diabatologia

      Volume: 55 Pages: 1745-1754

    • DOI

      D01: 10. 1 007/s00125-012-2521-5

  • [Journal Article] Saturated fatty acid and TLR signaling link (3 cell dysfunction and islet inflammation2012

    • Author(s)
      Eguchi K, Kadowaki T
    • Journal Title

      Cell Metal

      Volume: 15 Pages: 518-533

    • DOI

      D01:10. 1016/i. cmet.2012.01.023.

  • [Journal Article] Genetic risk score constructed using 14 susceptibility alleles for type 2 diabetes is associated with the early onset of diabetes and may predict the future requirement of insulin injections among Japanese individuals2012

    • Author(s)
      Iwata M, Hara K, Kadowaki T
    • Journal Title

      Diabetes Care

      Volume: 35 Pages: 1763-1770

    • DOI

      DOI:10.2337/ dc11-2006

  • [Journal Article] Potential Formula for the Calculation of Starting and Incremental Insulin Glargine Doses: ALOHA Subanalysis2012

    • Author(s)
      Kadowaki T, Ohtani T, Odawara M
    • Journal Title

      PLoSOne

      Volume: 7 Pages: e41358

    • DOI

      DOI:10.1371/journal. pone. 0 041353.

  • [Journal Article] In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokine and integrin signaling2012

    • Author(s)
      Nishimura S, Kadowaki T
    • Journal Title

      Blood

      Volume: 119 Pages: e45-56

    • DOI

      DOI10.1182/ blood-2011-09-381400

  • [Journal Article] Depletion of homeodomain-interacting protein kinase 3 impairs insulin secretion and glucose tolerance in mice2012

    • Author(s)
      Shojima N, Hara K, Kubota N, Yamauchi T, Ueki K, Kadowaki T
    • Journal Title

      Diabetologia

      Volume: 55 Pages: 3318-3330

    • DOI

      D01:10.1007/s00125-0 12-2711-1

  • [Journal Article] Erectile dysfunction and cardiovascular events in diabetic menmeta-analysis of observational studies2012

    • Author(s)
      Yamada T, Hara K, Umematsu H, Suzuki R, Kadowaki T.
    • Journal Title

      PLoS One

      Volume: 7 Pages: e43673

    • DOI

      DOI:10.1371/ journal.pone.0043673.

  • [Journal Article] Variations with modest effects have an important role in the genetic background of type 2 diabetes and diabetes-related traits2012

    • Author(s)
      Fujita H, Hara K, Kadowaki T
    • Journal Title

      J Hum Genet

      Volume: 57 Pages: 776-779

    • DOI

      DOI:10.1038/jhg.2012.110

  • [Journal Article] Snap Shot: Insulin Signaling Pathways2012

    • Author(s)
      Kadowaki T, Ueki K, Yamauchi T, Kubota N.
    • Journal Title

      Cep

      Volume: 148 Pages: 624-624

    • DOI

      D OI:10.1016/j. ce11.2012. 01.034.

  • [Journal Article] SnapShot: Physiology of Insulin Signaling2012

    • Author(s)
      Kadowaki T, Kubota N, Ueki K, Yamauchi T
    • Journal Title

      Ce11

      Volume: 148 Pages: 834-834

    • DOI

      D OI:10.1016/i.ce11.2 012.02.004.

  • [Journal Article] Monocyte chemoattractant protein-1 (MCP-1) deficiency enhances alternatively activated M2 macrophages and ameliorates insulin resistance and fatty liver in lipoatrophic diabetic A-ZIP transgenic mice2012

    • Author(s)
      Nio Y, Yamauchi T, Iwabu M, Okada-Iwabu M, Ueki K, Kadowaki T
    • Journal Title

      Diabetologia

      Volume: 55 Pages: 3350-3358

    • DOI

      DOI:10.1007/s00125-0 12-2710-2

  • [Journal Article] Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle2011

    • Author(s)
      Kubota T, Kubota N, Ueki K, Kadowaki T
    • Journal Title

      Cell Metabolism

      Volume: 13 Pages: 294-307

    • DOI

      DOI:10.1016/i.cmet.2011.01.018.

  • [Journal Article] Adiponectin enhances insulin sensitivity by increasing hepatic IRS-2 expression via a macrophage妖erived IL-6 dependent pathway2011

    • Author(s)
      Awazawa M, Ueki K, Yamauchi T, Kubota, Kadowaki T
    • Journal Title

      Cell Metabolism

      Volume: 13 Pages: 401-412

    • DOI

      DO1:10.1016/j.cmet.2011. 02.010

  • [Journal Article] Global mapping of cell type-specific open chromatin by FAIRE seq reveals the regulatory role of the NFI family in adipocyte differentiation2011

    • Author(s)
      Waki H, Yamauchi T, Iwabu M, Okada-Iwabu M, Ueki K, Kadowaki T
    • Journal Title

      PLoS Genetics

      Volume: 7 Pages: e1002311

    • DOI

      10.1371/journal.pgen.1002311

  • [Journal Article] Blockade of class lB phosphor inositide-3 kinase ameliorates obesity induced inflammation and insulin resistance2011

    • Author(s)
      Kobayashi N, Ueki, Kubota N, Hara K, Kadowaki T
    • Journal Title

      Proc. Nat/. Acad. Sci. U.S.A.

      Volume: 108 Pages: 5753-5758

    • DOI

      DOI:10.1073/anas.1016430108.

  • [Journal Article] Crystal structure of the Ca2+/Calmodulin-dependent protein kinase in complex with the inhibitor STO-6092011

    • Author(s)
      Kukimoto-Nino M, Yamauchi T, Okada Iwabu M, Iwabu M, Kadowaki T
    • Journal Title

      J. Biol. Chem.

      Volume: 286 Pages: 22570-22579

    • DOI

      DOI:10.1074/jbc.M111.251710.

  • [Journal Article] Meta-analysis of genome-wide asso- ciation studies identifies eight new loci for type 2 diabetes in east Asians2011

    • Author(s)
      Cho YS, Yamauchi T, Hara K, Kadowaki T
    • Journal Title

      Nature Genatics

      Volume: 44 Pages: 67-72

    • DOI

      D OI:10.1038/ng.1019.

  • [Journal Article] The other sweet face of XBP-12011

    • Author(s)
      Ueki K, Kadowaki T
    • Journal Title

      Nature Medicine

      Volume: 17 Pages: 246-248

    • DOI

      DOI:10.1038/nm0311-246

  • [Journal Article] Adiponectin receptor signaling: a new layer to the current model2011

    • Author(s)
      Kadowaki T, Yamauchi T
    • Journal Title

      Cell Metabolism

      Volume: 13 Pages: 123-124

    • DOI

      DOI:10.1016/j.cmet.2011.01.012.

  • [Journal Article] 5 f: Thiazolidinediones enhance sodium-coupled bicarbonate absorption from renal proximal ubules via PPARgamma-dependent non-genomic signaling2011

    • Author(s)
      Endo Y, Yamauchi T, Kubota N, Kadowaki T
    • Journal Title

      CellMetabolism

      Volume: 13 Pages: 550-561

    • DOI

      DOI:10.1016/j.cmet.2011.02.015.

  • [Journal Article] Apoptosis inhibitor of macrophage (AIM) is required for obesity-associated recruitment of inflamma- tory macrophages into adipose tissue2011

    • Author(s)
      Kurokawa J, Kubota N, Kadowaki T
    • Journal Title

      Proc. Natl. Acad. Sci. U.S.A

      Volume: 108 Pages: 12072-12077

    • DOI

      DOI:10.1073/pnas.1101841108.

  • [Journal Article] Loss of adiponectin promotes intestinal carcinogenesis in Min and wild-type mice2011

    • Author(s)
      Mutoh M, Kubota N, Kadowaki T
    • Journal Title

      Gastroenterology

      Volume: 140 Pages: 2000-2008

    • DOI

      DOI:10.1053/j.gastro.2011.02.019.

  • [Journal Article] The diabetogenic VPS13C/C2CD4A/C2CD4B rs7172432 variant impairs glucose-stimulated insulin response in 5,722 non-diabetic Danish individuals2011

    • Author(s)
      Grarup N, Yamauchi T, Hara K, Kadowaki T
    • Journal Title

      Diabetologia

      Volume: 54 Pages: 789-794

    • DOI

      DOI:10.1007/s00125-010-2031-2

  • [Journal Article] Adiponectin and AdipoRl regulate PGClalpha and mitochondria by Ca2+ and AMPK/SIRT12010

    • Author(s)
      Iwabu M, Yamauchi T, Okada-Iwabu M,, Kubota N, Ueki K, Kadowaki T
    • Journal Title

      Nature

      Volume: 464 Pages: 1313-1319,

    • DOI

      DOI:10.1038/nature08991

  • [Journal Article] genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B2010

    • Author(s)
      Yamauchi T, Ham K, Iwabu M, Okada-Iwabu M, Kadowaki T
    • Journal Title

      Nature Genetics

      Volume: 42 Pages: 864-868

    • DOI

      DOI:10.1038/ng.660.

  • [Journal Article] Class IA phosphatidylinositol 3-kinase in pancreatic beta cells controls insulin secretion by multiple mechanisms2010

    • Author(s)
      Kaneko K, Ueki K, Kadowaki T
    • Journal Title

      Cell Metabolism

      Volume: 12 Pages: 619-632

    • DOI

      DOI:10.1016/j.cmet.2010.11.005.

  • [Journal Article] Dietary restriction; Standing up for sirtuins2010

    • Author(s)
      Baur JA, Kadowaki T
    • Journal Title

      Science

      Volume: 329 Pages: 1012-1015

    • DOI

      DOI:10.1126/science.329.5995.1012.

  • [Journal Article] Macrophage-derived AIM is endocytosed into adipocytes and decreases lipid droplets via inhibition of fattty acid synthase activity2010

    • Author(s)
      Kurokawa J, Kubota N, Kadowaki T
    • Journal Title

      Cell Metabolism

      Volume: 11 Pages: 479-492

    • DOI

      DOI:10.1016/j.cmet.2010.04.013.

  • [Journal Article] A liver-derived secretory protein, selenoprotein P, causes insulin resistance2010

    • Author(s)
      Misu H, Kubota N, Kadowaki T
    • Journal Title

      Cell Metabolis

      Volume: 12 Pages: 483-495

    • DOI

      DOI:10.1016/4 cmet. 2010.09.015

  • [Journal Article] Long-term pancreas allograft survival in simultaneous pancreas-kidney transplantation by era: UN OS registry analysis2010

    • Author(s)
      Waki K, Terasaki PI, Kadowaki T
    • Journal Title

      Diabetes Care

      Volume: 33 Pages: 1789-1791

    • DOI

      DOI:10.2337/dc09-2276

  • [Journal Article] Identification of KCNJ15 as a susceptibility gene in Asian patients with type 2 diabetes mellitus2010

    • Author(s)
      Okamoto K,, Kadowaki T
    • Journal Title

      Am.J.Hum. Genet

      Volume: 86 Pages: 54-64

    • DOI

      DOI:10.1016/j.ajhg.2009.12.009.

  • [Journal Article] Regulatory polymorphism in transcription factor KLF5 at the MEF2 element alters the response to angiotensin 11 and is associated with human hypertension2010

    • Author(s)
      Oishi Y, Hara K, Kadowaki T
    • Journal Title

      FASBB J

      Volume: 24 Pages: 1780-1788

    • DOI

      DOI:10.1096/fj.09-146589

  • [Journal Article] The critical role of neutral cholesterol ester hydrolase 1 in cholesterol removal from human macrophages2010

    • Author(s)
      Igarashi M, Kadowaki T
    • Journal Title

      Circ. Res

      Volume: 107 Pages: 1387- 1395

    • DOI

      DOI:10.1161/ CIRCRESAHA.110. 226613.

  • [Journal Article] Polyunsaturated fatty acids selectively suppress sterol regulatory element-binding protein-1 through proteolytic processing and autoloop regulatory circuit2010

    • Author(s)
      Takeuchi Y, Kadowaki T
    • Journal Title

      J. Biol. Chem.

      Volume: 285 Pages: 11681-11691

    • DOI

      DOI:1 0.1074/jbc.M109.096107.

  • [Journal Article] Peroxisome proliferator-activated receptor gamma agonist rosiglitazone increases the expression of very low density lipoprotein receptor gene in adipocytes2009

    • Author(s)
      Takazawa T, Yamauchi T, Iwabu M, Okada-Iwabu M, Ueki K, Kadowaki T
    • Journal Title

      J. Biol. Chem.

      Volume: 284 Pages: 30049-30057

    • DOI

      DOI:1 0.1074/jbc.M109.047993.

  • [Journal Article] Rimonabant amelio- rates insulin resistance via both adipo- nectin-dependent and adiponectin -independent pathways2009

    • Author(s)
      atanabe T, Kubota N, Iwabu M, Yamauchi T, Ueki K, Kadowaki T
    • Journal Title

      J.Biol.Chem.

      Volume: 284 Pages: 1803-1812

    • DOI

      DOI:10.1074/jbc. M807120200.

  • [Journal Article] CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity2009

    • Author(s)
      Nishimura S, Hara K, Ueki K, Kadowaki T
    • Journal Title

      Nature Medicine

      Volume: 15 Pages: 914-920

    • DOI

      DOI10.1038/nm.1964.

  • [Journal Article] Ablation of neutral cholesterol easter hydrolase 1 accelerates atherosclerosis2009

    • Author(s)
      Sekiya M, Kadowaki T
    • Journal Title

      Cell Metabolism

      Volume: 10 Pages: 219-228

    • DOI

      DOI:10.1016/j.cmet.2009.08.004.

  • [Journal Article] Diabetes n Asia: epidemiology, risk factors, and pathophysiology2009

    • Author(s)
      Chan JC, Kadowaki T
    • Journal Title

      JAMA

      Volume: 301 Pages: 2129-2140

    • DOI

      DOI:10.1001/jama.2009.726.

  • [Journal Article] Critical role of class IA P13K for c-Rel expression in B lymphocytes2009

    • Author(s)
      Matsuda S, Kadowaki T
    • Journal Title

      Blood

      Volume: 113 Pages: 1037-1044

    • DOI

      DOI:10.1182/ blood- 2008-06-163725

  • [Journal Article] Neuronal IGF-1 resistance reduces Ab-accumulation and protects against premature death in a model of Alzheimer's disease2009

    • Author(s)
      Freude S, Kubota N, Kadowaki T
    • Journal Title

      FASEB J.

      Volume: 23 Pages: 3315-3324

    • DOI

      DOI:10.1096/fj.09-132043

  • [Journal Article] Replication study for the association of new meta-analysis-derived risk loci with sus- ceptibility to type 2 diabetes in 6,244 Japanese individuals2009

    • Author(s)
      Omori S, Kadowaki T
    • Journal Title

      Diabetologia

      Volume: 52 Pages: 1554-1560

    • DOI

      DOI:10.1007/s00125-00 9-1397-5.

  • [Journal Article] Glucose effects on beta-cell growth and survival require activation of insulin receptors and insulin receptor substrate 22009

    • Author(s)
      Assmann A, Kadowaki T
    • Journal Title

      Mol. Cell. Bio1.

      Volume: 29 Pages: 3219-3228

    • DOI

      DOI:10. 1128/MCB.01489-08.

  • [Journal Article] The death effector domain-containing DEDD supports S6K1 activity via preventing Cdk1- dependent inhibitory phosphor- rylation2009

    • Author(s)
      Kurabe N, Kubota N, Kadowaki T
    • Journal Title

      J. Biol. Chem.

      Volume: 284 Pages: 5050-5055

    • DOI

      DOI:10. 1074/jbc. M 808598200.

  • [Journal Article] Impact of small molecule glucokinase activator on glucose metabolism, and beta cell function and mass2009

    • Author(s)
      Nakamura A, Kubota N, Kadowaki T
    • Journal Title

      Endocrinology

      Volume: 150 Pages: 1147-1154

    • DOI

      DOI:1 0.1210/en.2008-1183.

  • [Journal Article] Targeting of neutral cholesterol ester hydrolase to the endoplasmic reticulum via its N-terminal sequence2009

    • Author(s)
      Igarashi M, Kadowaki T
    • Journal Title

      J. Lipid Res

      Volume: 51 Pages: 274-285

    • DOI

      DOI:10.1194/jlr. M90 0201-JLR200.

  • [Journal Article] Role of the liver in glucose homeostasis in P13-kinase p85{alpha}-deficient mice2009

    • Author(s)
      Aoki K, Kubota N, Kadowaki T
    • Journal Title

      Am. J. Physiol. Endocrinol. Metab

      Volume: 296 Pages: E842-853

    • DOI

      DOI:10.1152/aj pendo.90528.2008

  • [Journal Article] Alpha2-AMPK activity is not essential for an increase in fatty acid oxi- dation during low-intensity exercise2009

    • Author(s)
      Miura S, Kubota N, Kadowaki T, Ezaki O, et al.
    • Journal Title

      Am. J. Physiol. Endocrinol. Metab.

      Volume: 296 Pages: E47-E55

    • DOI

      DOI:10.1152/ajpendo.90690.2008.

  • [Journal Article] Dynamic functional relay between insulin receptor substrate-1 and -2 in hepatic insulin signaling during fasting and feeding2008

    • Author(s)
      Kubota N, Ueki K, Kadowaki T
    • Journal Title

      Cell Metabolism

      Volume: 8 Pages: 49-64

    • DOI

      DOI:10.1016/j. cmet.2008.05.007.

  • [Journal Article] Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus2008

    • Author(s)
      Yasuda K, Hara K, Kadowaki T
    • Journal Title

      Nature Genetics

      Volume: 40 Pages: 1092-1097

    • DOI

      DOI:10.1038/ng.207.

  • [Journal Article] SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations2008

    • Author(s)
      Unoki H, Hara K, Kadowaki T
    • Journal Title

      Nature Genetics

      Volume: 40 Pages: 1098-1102

    • DOI

      DOI:10.1038/ng.208.

  • [Journal Article] Adiponectin induces insulin secretion in vitro and in vivo at a low glucose concentration2008

    • Author(s)
      Okamoto M, Kubota N, Kadowaki T
    • Journal Title

      Diabetologia

      Volume: 51 Pages: 827-835

    • DOI

      DOI:10.1007/s00125-008- 0944-9.

  • [Journal Article] SUMOylation of Kruppel-like transcription factor 5 acts as a molecular switch in transcriptional programs of lipid metabolism involving PPAR-delta.2008

    • Author(s)
      Oishi Y, Kubota N, Kadowaki T
    • Journal Title

      Nature Medicine

      Volume: 14 Pages: 656-666

    • DOI

      DOI: 10.1038/nm1756.

  • [Journal Article] In vivo imaging in mice reveals local cell dynamics and inflammation in obese adipose tissue2008

    • Author(s)
      Nishimura S, Kadowaki T
    • Journal Title

      J.Clin.Invest.

      Volume: 118 Pages: 710-721

    • DOI

      DOI:10.1172/JC133328.

  • [Journal Article] KLF6 in non-alcoholic fatty liver disease: role of fibrogenesis and carcinogenesis2008

    • Author(s)
      Watanabe K, Kadowaki T
    • Journal Title

      Gastroenterology

      Volume: 135 Pages: 309-312

    • DOI

      DOI:10.1053/j.gastro.2008.06.014.

  • [Journal Article] Adiponectin suppresses colorectal carcinogenesis under the high-fat diet condition2008

    • Author(s)
      Fujisawa T, Kubota N, Yamauchi T, Kadowaki T
    • Journal Title

      Gut

      Volume: 57 Pages: 1531-1538

    • DOI

      DOI:10.1136/gut.2008.159293.

  • [Journal Article] Glimepiride-induced bronchial asthma: case report2008

    • Author(s)
      Tsukamoto K, Kadowaki T
    • Journal Title

      Diabetes Care

      Volume: 31 Pages: e91

    • DOI

      DOI:10.2337/dc08-1536.

  • [Journal Article] Identification of neutral cholesterol ester hydrolase, a key enzyme removing cholesterol from macrophages2008

    • Author(s)
      Okazaki H, Kadowaki T
    • Journal Title

      J.Biol. Chem.

      Volume: 283 Pages: 33357-33364

    • DOI

      DOI: 10.1074/jbc.M802686200.

  • [Journal Article] Association of adenovirus 36 infection with obesity and metabolic markers in humans: a meta-analysis of observational studies

    • Author(s)
      Yamada T, Hara K, Kadowaki T
    • Journal Title

      PLoS One

      Volume: 7 Pages: e42031,

    • DOI

      DO1:10.1371/iourna1.none.0042031

  • [Presentation] AdipoRs activation increases Ca2+ and AMPK/SIRT/PGC-1, thereby regulating metabolic stress and mitochondria, leading to anti-aging and amelioration of diseases of aging2012

    • Author(s)
      Takashi Kadowaki
    • Organizer
      KEYSTONE SYMPOSIA: Aging and Diseases of Aging
    • Place of Presentation
      TOKYO
    • Year and Date
      2012-10-26
  • [Presentation] Adiponectin action through AMPK2011

    • Author(s)
      Takashi Kadowaki
    • Organizer
      American Diabetes Association 71st Scientific Sessions
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2011-06-26
  • [Presentation] Multiple aspects of molecular mechanism of insulin resistance in type2 diabetes2011

    • Author(s)
      Takashi Kadowaki
    • Organizer
      76th Cold Spring Harbor Laboratory Symposium
    • Place of Presentation
      Cold Spring Harbor, USA
    • Year and Date
      2011-06-02
  • [Book] アディポネクチンとその受容体-抗生活習慣病ホルモンの全貌(単行本)2008

    • Author(s)
      門脇孝
    • Publisher
      フジメディカル出版
  • [Book] あなたがメタボになる理由(単行本)2008

    • Author(s)
      門脇孝
    • Publisher
      PHP研究所
  • [Remarks]

    • URL

      http://dm301k.umin.jp/

  • [Patent(Industrial Property Rights)] 擬似運動療法のための医薬2011

    • Inventor(s)
      門脇孝、山内敏正、他2名
    • Industrial Property Rights Holder
      (株)東京大学TLO
    • Industrial Property Number
      PCT/JP2011/056043
    • Filing Date
      2011-03-15
    • Overseas
  • [Patent(Industrial Property Rights)] アディポネクチン受容体及びそれをコードする遺伝子2010

    • Inventor(s)
      門脇孝、山内敏正、他2名
    • Industrial Property Rights Holder
      東京大学TLO、日産化学工業(株)
    • Industrial Property Number
      特許権:4442908
    • Acquisition Date
      2010-01-22

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Published: 2014-08-29   Modified: 2023-03-16  

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