2012 Fiscal Year Final Research Report
Integrated elucidation of metabolic pathway in the physiology and pathology
| Project/Area Number |
20229008
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| Research Category |
Grant-in-Aid for Scientific Research (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
Metabolomics
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
UEKI Kohjiro 東京大学, 医学部附属病院, 准教授 (00396714)
YAMAUCHI Toshimasa 東京大学, 医学部附属病院, 講師 (40372370)
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| Co-Investigator(Renkei-kenkyūsha) |
HARA Kazuo 東京大学, 医学部附属病院, 特任准教授 (50359600)
KUBOTA Naoto 東京大学, 医学部附属病院, 特任准教授 (50396719)
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| Project Period (FY) |
2008 – 2012
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| Keywords | アディポネクチン / インスリン / AdipoR / 糖代謝 / 脂質代謝 |
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| Research Abstract |
An integrated understanding of metabolic regulation and its disruption is essential in elucidating the pathophysiology of diabetes and the metabolic syndrome as well as in developing therapeutic modalities for these conditions. In this connection, we contributed to generating scientific evidence that constitutes a basis for the development of anti妖iabetic therapies targeted at the regulation of insulin and/or adiponectin action as well as to the discovery of candidate anti-diabetic compounds, by elucidating the mechanisms involved in the inter-organ cross-walks in the regulation of insulin and/or adiponectin action.
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