2011 Fiscal Year Final Research Report
Sensor proteins and cellular protection factors for environmental electrophiles
| Project/Area Number |
20241015
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKANO Hirohisa 京都大学, 工学研究科, 教授 (60281698)
INOUE Kenichiro 北里大学, 薬学部, 教授 (20373219)
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| Project Period (FY) |
2008 – 2011
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| Keywords | 親電子化合物 / 共有結合 / 多環芳香族炭化水素キノン体 / ヒ素 / メチル水銀 |
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| Research Abstract |
Exposure of environmental electrophiles to cultured cells and experimental animals caused a covalent or oxidative modification of the reactive thiols of sensor proteins such as PTP1B and Keap1, thereby activating EGFR and Nrf2, respectively. Our findings suggest that environmental electrophiles invade into cells, and then can modulate cellular signal transduction pathways (e.g., initial response, cell proliferation and apoptotic cell death) in a concentration-dependent manner
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[Journal Article] Initial response and cellular protection through the Keap1/Nrf2 system during exposure of primary mouse hepatocytes to 1, 2-naphthoquinone2011
Author(s)
Miura T, Shinkai Y, Jiang HY, Iwamoto N, Sumi D, Taguchi K, Yamamoto M, Jinno H, Tanaka-Kagawa T, Cho AK, Kumagai Y
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Journal Title
Chemical Research in Toxicology
Volume: 24
Pages: 559-567
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[Journal Article] Involvement of sensory nerves and TRPV1 receptors in the rat airway inflammatory response to two environment pollutants : diesel exhaust particles (DEP) and 1, 2-naphthoquinone (1, 2-NQ)2010
Author(s)
Teles AM, Kumagai Y, Brain SD, Teixeira SA, Varriano AA, Barreto MA, de Lima WT, Antunes E, Muscara MN, Costa SK
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Journal Title
Archives of Toxicology
Volume: 84
Pages: 109-117
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[Journal Article] Redox cycling of 9, 10-phenanthraquinone to cause oxidative stress is terminated through its monoglucuronide conjugation in human pulmonary epithelial A549 cells2008
Author(s)
Taguchi K, Shimada M, Fujii S, Sumi D, 24. Taguchi K, Shimada M, Fujii S, Sumi D, Pan XQ, Yamano S, Nishiyama T, Hiratsuka A, Yamamoto M, Cho AK, Froines JR, Kumagai Y
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Journal Title
Free Radical Biology & Medicine
Volume: 44
Pages: 1645-1655
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