2012 Fiscal Year Final Research Report
A large-scale cohort study for preventing lifestyle-related diseases and clarifying gene-environment interactions on the development of such diseases
| Project/Area Number |
20249038
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Saga University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SHINCHI Koichi 佐賀大学, 医学部, 教授 (30404164)
HIGAKI Yasuki 福岡大学, スポーツ科学部, 教授 (10228702)
HARA Megumi 佐賀大学, 医学部, 教授 (90336115)
NISHIDA Yuichiro 佐賀大学, 医学部, 助教 (50530185)
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| Project Period (FY) |
2008 – 2012
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| Keywords | 生活習慣病 / がん / 危険因子 / 遺伝子環境交互作用 / コーホート研究 |
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| Research Abstract |
This study aimed to clarify environmental and genetic factors and their interactions on the development of lifestyle-related diseases such as cancer, based on a 20-year follow-up of about 12000 residents in Saga city. We conducted a follow-up survey (183 deaths and 267 cancer cases identified), a reproducibility study of a lifestyle questionnaire (434 subjects included), cross-sectional studies (e.g., diet, physical activity, stress, and genetic polymorphisms in association with inflammation and blood sugar), and a secondary survey 5 years after the baseline survey (8454 subjects included). We will continue a follow-up and perform longitudinal studies in the future.
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[Journal Article] Profile of participants and genotype distributions of 108 polymorphisms in a cross-sectional study of associations of genotypes with lifestyle and clinical factors: a project in the Japan Multi-institutional Collaborative Cohort (J-MICC) Study.2011
Author(s)
K. Wakai, N. Hamajima, R. Okada, M. Naito, E. Morita, A. Hishida, S. Kawai, K. Nishio, G. Yin, Y. Asai, K. Matsuo, S. Hosono, H. Ito, M. Watanabe, T. Kawase, T. Suzuki, K. Tajima, K. Tanaka, Y. Higaki, M. Hara, T. Imaizumi, N. Taguchi, K. Nakamura, H. Nanri, T. Sakamoto, M. Horita, K. Shinchi, et al(49 others)
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Journal Title
J. Epidemiol.
Volume: 21
Pages: 223-235
DOI
Peer Reviewed
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[Journal Article] Optimal cutoff values of waist circumference and the discriminatory performance of other anthropometric indices to detect the clustering of cardiovascular risk factors for metabolic syndrome in Japanese men and women2011
Author(s)
Nakamura, K., Nanri, H., Hara, M., Higaki, Y., Imaizumi, T., Taguchi, N., Sakamoto, T., Horita, M., Shinchi, K., Tanaka, K.
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Journal Title
Environ. Health Prev. Med.
Volume: 16
Pages: 52-60
DOI
Peer Reviewed
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