2012 Fiscal Year Final Research Report
Establishment of molecular forensic diagnosis related with cytokines and chemokines
| Project/Area Number |
20249040
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Legal medicine
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KIMURA Akihiko 和歌山県立医科大学, 医学部, 准教授 (60136611)
ISHIDA Yuko 和歌山県立医科大学, 医学部, 講師 (10364077)
MIYAISHI Satoru 岡山大学, 医歯(薬)学総合研究科, 教授 (90239343)
IKEMATSU Kazuya 長崎大学, 医歯(薬)学総合研究科, 教授 (80332857)
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| Project Period (FY) |
2008 – 2012
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| Keywords | 法医病理学 / 分子法医学診断 / サイトカイン / ケモカイン / 遺伝子欠損マウス / 敗血症 / 薬物中毒 |
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| Research Abstract |
In order to establish novel molecular forensic diagnosis, we focus on cytokines/chemokines as the marker of systemic vital reactions, and examined the systemic dynamics of cytokines/chemokines in the various models of diseases, drug intoxication, and injuries, which are often encountered in forensic practices. We could find the several candidates cytokines/chemokines as key players in the models of sepsis, drowning, drug intoxication (acetaminophen, arsenite, cisplatin, chlorpromazine), deep vein thrombosis, acute pancreatitis, traumatic shock, and ischemia-reperfusion skeletal muscle injury, and identify specifics markers for molecular forensic diagnosis.
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