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2010 Fiscal Year Final Research Report

Investigation for the establishment of gender-sensitive geriatric medicine

Research Project

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Project/Area Number 20249041
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field General internal medicine (including Psychosomatic medicine)
Research InstitutionThe University of Tokyo

Principal Investigator

OUCHI Yasuyoshi  The University of Tokyo, 医学部附属病院, 教授 (80168864)

Co-Investigator(Kenkyū-buntansha) AKISHITA Masahiro  東京大学, 医学部附属病院, 准教授 (00261975)
ETO Masato  東京大学, 医学部附属病院, 特任准教授 (80282630)
IIJIMA Katsuya  東京大学, 医学部附属病院, 講師 (00334384)
OGAWA Sumito  東京大学, 医学部附属病院, 講師 (20323579)
OTA Hidetaka  東京大学, 医学部附属病院, 助教 (20431869)
Project Period (FY) 2008 – 2010
Keywords健康寿命延長 / 女性外来 / 性ホルモン / 性差 / 老年症候群 / 長寿遺伝子
Research Abstract

This project was conducted to investigate the gender difference in age-related diseases and their pathogenesis. The study group examined and reported on the role of androgen receptor and Sirt1 in the process of aging, the gender difference and the role of sex hormones in frailty as well as in metabolic syndrome and atherosclerosis. Also, the questionnaire survey to hospitals revealed agendas and needs for the practical and educational system of gender-sensitive medicine.

  • Research Products

    (25 results)

All 2010 2009 2008 Other

All Journal Article (12 results) (of which Peer Reviewed: 12 results) Presentation (10 results) Book (2 results) Remarks (1 results)

  • [Journal Article] Aortic arch calcification detectable on chest X-ray is a strong independent predictor of cardiovascular events beyond traditional risk factors2010

    • Author(s)
      Iijima K, Hashimoto H, Hashimoto M, Son BK, Ota H, Ogawa S, Eto M, Akishita M, Ouchi Y
    • Journal Title

      Atherosclerosis 210

      Pages: 137-44

    • Peer Reviewed
  • [Journal Article] Association of low testosterone with metabolic syndrome and its components in middle-aged Japanese men2010

    • Author(s)
      Akishita M, Fukai S, Hashimoto M, Kameyama Y, Nomura K, Nakamura T, Ogawa S, Iijima K, Eto M, Ouchi Y
    • Journal Title

      Hypertens Res 33

      Pages: 587-91

    • Peer Reviewed
  • [Journal Article] Low testosterone level as a predictor of cardiovascular events in Japanese men with coronary risk factors2010

    • Author(s)
      Akishita M, Hashimoto M, Ohike Y, Ogawa S, Iijima K, Eto M, Ouchi Y
    • Journal Title

      Atherosclerosis 210

      Pages: 232-236

    • Peer Reviewed
  • [Journal Article] Visceral fat accumulation and metabolic risk factor clustering in older adults2010

    • Author(s)
      Nomura K, Eto M, Kojima T, Ogawa S, Iijima K, Nakamura T, Araki A, Akishita M, Ouchi Y
    • Journal Title

      J Am Geriatr Soc. 58

      Pages: 1658-63

    • Peer Reviewed
  • [Journal Article] Induction of endothelial nitric oxide synthase, SIRT1, and catalase by statins inhibits endothelial senescence through the Akt pathway2010

    • Author(s)
      Ota H, Eto M, Kano MR, Kahyo T, Setou M, Ogawa S, Iijima K, Akishita M, Ouchi Y
    • Journal Title

      Arterioscler Thromb Vasc Biol. 30

      Pages: 2205-11

    • Peer Reviewed
  • [Journal Article] Androgen receptor-dependent transactivation of growth arrest-specific gene 6 mediates inhibitory effects of testosterone on vascular calcification2010

    • Author(s)
      Son BK, Akishita M, Iijima K, Ogawa S, Maemura K, Yu J, Takeyama K, Kato S, Eto M, Ouchi Y
    • Journal Title

      J Biol Chem 285

      Pages: 7537-44

    • Peer Reviewed
  • [Journal Article] Androgen receptor-dependent activation of endothelial nitric oxide synthase in vascular endothelial cells: Role of PI3-kinase/Akt pathway2010

    • Author(s)
      Yu J, Akishita M, Eto M, Ogawa S, Son BK, Kato S, Ouchi Y, Okabe T
    • Journal Title

      Endocrinology 151

      Pages: 1822-8

    • Peer Reviewed
  • [Journal Article] Plasma sex hormone levels and mortality in disabled older men and women2010

    • Author(s)
      Fukai S, Akishita M, Yamada S, Ogawa S, Yamaguchi K, Kozaki K, Toba K, Ouchi Y
    • Journal Title

      Geriatr Gerontol Int. (Epub ahead of print)

    • Peer Reviewed
  • [Journal Article] Sirolimus and everolimus induce endothelial cellular senescence via sirtuin 1 down-regulation : therapeutic implication of cilostazol after drug-eluting stent implantation2009

    • Author(s)
      Ota H, Eto M, Ako J, Ogawa S, Iijima K, Akishita M, Ouchi Y
    • Journal Title

      J Am Coll Cardiol. 53

      Pages: 2298-305

    • Peer Reviewed
  • [Journal Article] Association of plasma sex hormone levels with functional decline in elderly men and women2009

    • Author(s)
      Fukai S, Akishita M, Yamada S, Hama T, Ogawa S, Iijima K, Eto M, Kozaki K, Toba K, Ouchi Y
    • Journal Title

      Geriatr Gerontol Int. 9

      Pages: 282-9

    • Peer Reviewed
  • [Journal Article] Validity and usefulness of aortic arch calcification in chest X-ray2009

    • Author(s)
      Hashimoto H, Iijima K, Hashimoto M, Son BK, Ota H, Ogawa S, Eto M, Akishita M, Ouchi Y
    • Journal Title

      J Atheroscler Thromb. 16

      Pages: 256-64

    • Peer Reviewed
  • [Journal Article] Cilostazol inhibits oxidative stress-induced premature senescence via upregulation of Sirt1 in human endothelial cells2008

    • Author(s)
      Ota H, Eto M, Kano MR, Ogawa S, Iijima K, Akishita M, Ouchi Y
    • Journal Title

      Arterioscler Thromb Vasc Biol. 28

      Pages: 1634-9

    • Peer Reviewed
  • [Presentation] Plasma Sex Hormone Levels and Mortality in Disabled Older Men2010

    • Author(s)
      Fukai S, Ouchi Y, et al
    • Organizer
      Men's Health World Congress
    • Place of Presentation
      Nice, France
    • Year and Date
      20101028-20101030
  • [Presentation] Association of low testosterone level with the metabolic syndrome and its components in middle-aged Japanese men2010

    • Author(s)
      Umeda-Kameyama Y, Ouchi Y, et al
    • Organizer
      Men's Health World Congress
    • Place of Presentation
      Nice, France
    • Year and Date
      20101028-20101030
  • [Presentation] Vascular endothelial cell senescence and Sir2/Sirt12010

    • Author(s)
      大内尉義
    • Organizer
      The World Economic Forum Annual Meeting 2010
    • Place of Presentation
      Tianjin, China
    • Year and Date
      20100912-20100915
  • [Presentation] Src kinase mediates non-genomic pathway of endothelial nitric oxide synthase activation by testosterone in vascular endothelial cell2010

    • Author(s)
      Yu J, Ouchi Y, et al
    • Organizer
      日本動脈硬化学会学術集会
    • Place of Presentation
      岐阜
    • Year and Date
      20100715-20100716
  • [Presentation] 老年病科入院患者における老年症候群重積数からみた性差2010

    • Author(s)
      亀山祐美、大内尉義, ほか
    • Organizer
      日本性差医学・医療学会
    • Place of Presentation
      東京
    • Year and Date
      20100220-20100221
  • [Presentation] 医学部生への性差医学・医療教育への取り組み-老年病科BSL中に実施している性差医学医療セミナーに関して-2010

    • Author(s)
      宮尾益理子、大内尉義, ほか
    • Organizer
      日本性差医学・医療学会
    • Place of Presentation
      東京
    • Year and Date
      20100220-20100221
  • [Presentation] 地域在住高齢者における食品摂取状況の性差およびるい痩との関連性2010

    • Author(s)
      柴崎孝二、大内尉義, ほか
    • Organizer
      日本成人病(生活習慣病)学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      20100109-20100110
  • [Presentation] 中高年男性の健康とアンドロゲン2010

    • Author(s)
      大内尉義
    • Organizer
      日本内科学会中国支部生涯教育講演会
    • Place of Presentation
      岡山
    • Year and Date
      2010-11-14
  • [Presentation] 長寿遺伝子Sirt1と血管の老化2010

    • Author(s)
      大内尉義
    • Organizer
      日本抗加齢医学会総会
    • Place of Presentation
      京都
    • Year and Date
      2010-06-13
  • [Presentation] 高齢生活習慣病患者における易転倒性の加齢変化と性差2009

    • Author(s)
      小島太郎、大内尉義, ほか
    • Organizer
      日本老年医学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      20090618-20090620
  • [Book] 新老年学 第3版2010

    • Author(s)
      大内尉義,秋山弘子,折茂肇編
    • Publisher
      東京大学出版会・東京
  • [Book] 性差医療の考え方と課題 性差とは何か-ジェンダー研究と生物学との対話2008

    • Author(s)
      大内尉義、日本学術協力財団編
    • Publisher
      日本学術協力財団・東京
  • [Remarks] ホームページ等

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Published: 2012-01-26   Modified: 2016-04-21  

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