Medical innovation of a treatment for diabetes by introducing non-invasive diagnostic system for minimal tissues

2010 Fiscal Year Self-evaluation Report

• Project/Area Number: 20249057
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General surgery
• Research Institution: Tohoku University
• Principal Investigator: SATOMI Susumu Tohoku University, 病院, 教授 (00154120)
• Project Period (FY): 2008 – 2011
• Keywords: 糖尿病 / 細胞・組織 / 移植 / 膵島

Research Abstract

膵島移植を一般医療として確立するには、膵島の活性・機能を迅速かつ的確に診断できるデバイスの開発、及びそのデバイス活用による革新的膵島分離システムの構築が不可欠である。本研究においては、東北大学の特色である医工連携という異分野融合の強みを最大限に活かし、電気化学計測技術を基盤とする非侵襲性微小組織診断システムを導入する事により膵島移植の成績を飛躍的に向上させ、膵島移植を糖尿病に対する理想的治療法として確立する事を目的としている。

Research Products

• [Journal Article] Quantification of the islet product : Presentation of a standardized current Good Manufacturing Practices compliant system with minimal variability (2011)
  • Author(s): Friberg A, Brandhorst H, Buchwald P, Goto M, Ricordi C, Brandhorst D, Korsgren O
  • Journal Title: Transplantation 91 Pages: 677-683
  • Peer Reviewed
• [Journal Article] Attenuation of cross-talk between the complement and coagulation cascades by C5a blockade improves early outcomes after intraportal islet transplantation (2010)
  • Author(s): Tokodai K, Goto M, Inagaki A, Nakanishi W, Ogawa N, Satoh K, Kawagishi N, Sekiguchi S, Nilsson B, Okada N, Okada H, Satomi S
  • Journal Title: Transplantation 90(12) Pages: 1358-1365
  • Peer Reviewed
• [Journal Article] The impact of ischemic stress on the quality of isolated pancreatic islets (2010)
  • Author(s): Goto M, Imura T, Inagaki A, Ogawa N, Yamaya H, Fujimori K, Kurokawa Y, Satomi S
  • Journal Title: Transplantation Proc 42(6) Pages: 2040-2042
  • Peer Reviewed
• [Journal Article] Brain death in combination with warm ischemic stress during isolation procedures induces the expression of crucial inflammatory mediators in the isolated islets (2010)
  • Author(s): Saito Y, Goto M, Maya K, Ogawa N, Fujimori K, Kurokawa Y, Satomi S
  • Journal Title: Cell Transplantation 19(6) Pages: 775-782
  • Peer Reviewed
• [Journal Article] Simultaneous non-contact topography and electrochemical imaging by SECM/SICM featuring ion current feedback regulation. (2010)
  • Author(s): Y.Takahashi, A.I.Shevchuk, P.Novak, Y.Murakami, H.Shiku, Y.E.Korchev, T.Matsue
  • Journal Title: J.Am.Chem.Soc. 132 Pages: 10118-10126
  • Peer Reviewed
• [Presentation] No Need of Tryptic-like Activity for Successful Porcine Islet Isolation (2010)
  • Author(s): Masafumi Goto, Youhei Yamagata, Kimiko Watanabe, Kazutaka Murayama, Takehiro Imura, Akiko Inagaki, Hideyuki Yamaya, Keisei Fujimori, Yoshimochi Kurokawa, Susumu Satomi
  • Organizer: 2010 XXIII International Congress Of The Transplantation Society
  • Place of Presentation: Canada, Vancouver
  • Year and Date: 20100815-20100819
• [Presentation] Interruption of a cross-talk between the complement and coagulation cascades improves early outcomes after intraportal islet transplantation (2010)
  • Author(s): Kazuaki Tokodai, Masafumi Goto, Akiko Inagaki, Wataru Nakanishi, Noriko Okada, Hidechika Okada, Susumu Satomi
  • Organizer: 2010 XXIII International Congress Of The Transplantation Society
  • Place of Presentation: Canada, Vancouver
  • Year and Date: 20100815-20100819
• [Presentation] 膵島移植の現状と今後の展望 (2010)
  • Author(s): 後藤昌史
  • Organizer: 第13回近畿膵移植検討会
  • Place of Presentation: 大阪(招待講演)
  • Year and Date: 2010-11-04
• [Presentation] マイクロバイオデバイスの化学 (2010)
  • Author(s): 末永智一
  • Organizer: 分析化学会第59年会シンポジウム
  • Place of Presentation: 仙台(招待講演)
  • Year and Date: 2010-09-17
• [Presentation] 長期冷保存を伴う膵島移植を対象とした臓器保存溶液に関する検討 (2010)
  • Author(s): 猪村武弘、後藤昌史、藤盛啓成、黒川良望、里見進
  • Organizer: 第37回膵膵島移植研究会
  • Place of Presentation: 宇都宮
  • Year and Date: 2010-03-13