2011 Fiscal Year Final Research Report
Comprehensive analysis of neuronal regeneration, inflammation and gene therapy for post-ischemic insult by using experimental stroke models
| Project/Area Number |
20249063
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SAITO Nobuhito 東京大学, 医学部附属病院, 教授 (60262002)
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| Co-Investigator(Kenkyū-buntansha) |
IMAI Hideaki 東京大学, 医学部附属病院, 特任講師 (70359587)
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| Research Collaborator |
MIYAWAKI Satoru 東京大学, 大学院生
ONO Hideaki 東京大学, 大学院生
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| Project Period (FY) |
2008 – 2011
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| Keywords | 脳虚血 / 神経再生 / 炎症 / プロテオミクス / 幹細胞 |
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| Research Abstract |
By applying variety of experimental stroke models for the basic research, we have exerted the comprehensive analysis of neuronal regeneration, inflammation and ischemic tolerance after ischemic insult. For the possibility of axonal regeneration treated by the cell transplantion, the small number of the transplanted cells remain in the lesion, appearing just homing, neither proliferation nor rewiring. In terms of the immunoreactions to ischemic insult of the brain, Cyclophilin C-associated protein(CyCAP), via stimulating calcineurin phosphatase activity, plays a pivotal role for activation of macrophage. The phenomenon of ischemic tolerance may link hypoxic preconditioning with vascular remodeling.
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[Journal Article] Experimental investigation of encephalo-myo-synangiosis using gyrencepharic brain of the miniature pig : histopathological evaluation of dynamic reconstruction of vessels for functional anastomosis2009
Author(s)
Nakamura M, Imai H, konno K, Kubota C, Seki K, Puentes S, Faired A, Yokoo H, Hata H, Yohimoto Y, Saito N.
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Journal Title
J Neurosurg Pediatr
Volume: 3(6)
Pages: 488-495
DOI
Peer Reviewed
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[Journal Article] Experimental Model of Lacunar Infarction in the Gyrencephalic Brain of the Miniature Pig : Neurological Assessment and Histological, Immunohistochemical, and Physiological Evaluation of Dynamic Corticospinal Tract Deformation2008
Author(s)
Tanaka Y, Imai H, Konno K, Miyagishima T, Kubota C, Puentes S, Aoki T, Hata H, Takata K, Yoshimoto Y, Saito N.
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Journal Title
Stroke
Volume: 39
Pages: 205-212
DOI
Peer Reviewed
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