2010 Fiscal Year Final Research Report
Novel PET ligands for brain-function imaging with the brain-targeting peptide molecules
| Project/Area Number |
20300127
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Nagoya University |
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Principal Investigator |
SAWADA Makoto Nagoya University, 環境医学研究所, 教授 (10187297)
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| Co-Investigator(Kenkyū-buntansha) |
TOYAMA Hiroshi 藤田保健衛生大学, 医学部, 准教授 (90247643)
HATANO Kentaro 国立長寿医療センター, 室長 (50228475)
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| Co-Investigator(Renkei-kenkyūsha) |
ONO Kenji 名古屋大学, 環境医学研究所, 助教 (80329698)
SUZUKI Hiromi 名古屋大学, 環境医学研究所, 助教 (30340269)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 脳・神経 / 放射線 / PET / 脳移行性 / イメージング |
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| Research Abstract |
We investigated the feasibility of our originally established brain-targeting (BT) peptide for novel ligand development of brain PET imaging. We successfully demonstrated the potential of [11C]MQNB-BT peptide conjugate in brain-penetrating activity, whereas [11C]MQNB itself has no such activity. Quantitative analysis indicated that [11C]MQNB-BT peptide conjugate had about 10% brain-penetrating activity of [11C]NMPB, which is permeable to blood-brain barrier. These results suggested that BT peptide has a potential of a DDS carrier for brain function imaging tools.
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[Journal Article] Time-dependent changes in proinfl-ammatory and neurotrophic responses of microglia and astrocytes in a rat model of osmotic demyelination syndrome.2011
Author(s)
IWAMA S, SUGIMURA Y, SUZUKI H, SUZUKI H, MURASE T, OZAKI N, NAGASAKI H, ARIMA H, MURATA Y, SAWADA M, OISO Y
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Journal Title
Glia 59(3)
Pages: 452-462
Peer Reviewed
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[Journal Article] Quantum dots labeling using octa-arginine peptides for imaging of adipose tissue-derived stem cells.2010
Author(s)
YUKAWA H, KAGAMI Y, WATANABE M, OISHI K, MIYAMOTO Y, OKAMOTO Y, TOKESHI M, KAJI N, NOGUCHI H, ONO K, SAWADA M, et al.
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Journal Title
Biomaterials 31(14)
Pages: 4094-4103
Peer Reviewed
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[Journal Article] In vivo imaging of microglial activation using a peripheral benzodiazepine receptor ligand : [11C] PK-11195 and animal PET following ethanol injury in rat striatum.2008
Author(s)
TOYAMA H, HATANO K, SUZUKI H, ICHISIE M, MOMOSAKI S, KUDO G, ITO F, KATO T, YAMAGCCHI H, KATADA K, SAWADA M, ITO K
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Journal Title
Ann Nucl Med 22(5)
Pages: 417-424
Peer Reviewed
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[Remarks] ホームページ等
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