2010 Fiscal Year Final Research Report
Development of rat resources for human models of type 2 diabetes accompanied with obesity.
| Project/Area Number |
20300145
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory animal science
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| Research Institution | The University of Tokushima |
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Principal Investigator |
MATSUMOTO Kozo The University of Tokushima, 総合生命科学部, 教授 (00002246)
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| Co-Investigator(Kenkyū-buntansha) |
HIROYUKI Kose 国際基督教大学, 教養学部, 准教授 (90314856)
KAZUHIKO Ochiai 徳島大学, ヘルスバイオサイエンス研究部, 助教 (30550488)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 肥満 / 糖尿病 / ラット / モデル動物開発 |
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| Research Abstract |
We developed a single congenic rat introgressed Nidd4 or Nidd6 locus responsible for the onset of diabetes in obese type 2 diabetes rat, OLETF. We chose F344 rat as the background strain. We found that both single congenic strains showed significantly higher body weight, abdominal fat volume and fasting glucose, respectively. From these results, we conclude that a diabetes gene(s) accompanied with obesity exists in the region for Nidd4 and Nidd6 loci.
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