Role of mechanical load in human myocardial excitation contraction coupling

2010 Fiscal Year Final Research Report

• Project/Area Number: 20300159
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Okayama University
• Principal Investigator: IRIBE Gentarou Okayama University, 大学院・医歯薬学総合研究科, 助教 (90284885)
• Co-Investigator(Renkei-kenkyūsha): NARUSE Keiji 岡山大学, 医歯(薬)学総合研究科, 教授 (40252233) ; MOURI Satoshi 川崎医科大学, 医学部, 教授 (00294413) ; KATANOSAKA Yuki 岡山大学, 医歯(薬)学総合研究科, 助教 (60432639) ; SANO Shunji 岡山大学, 医歯(薬)学総合研究科, 教授 (50235438) ; OOSHIMA Yuu 岡山大学, 医歯(薬)学総合研究科, 助教 (80364347)
• Project Period (FY): 2008 – 2010
• Keywords: 生体システム・フィジオーム / 数理モデル

Research Abstract

The normal heartbeat is the results of complex interactions of individual cardiomyocytes in the heart. Any mechanical disturbance in their interaction could be the risk of heart rhythm disturbances. In the present study, we revealed the underlying mechanisms that cause mechanically-induced arrhythmic beat by investigating mechanically-induced influx and efflux of ions via mechano-sensitive channels.

Research Products

• [Journal Article] Effects of axial stretch on sarcolemmal BKCa channels in post-hatch chick ventricular myocytes. (2010)
  • Author(s): Iribe G, Jin H, Kaihara K, Naruse K.
  • Journal Title: Exp Physiol. 95(6) Pages: 699-711
  • Peer Reviewed
• [Journal Article] Axial stretch of rat single ventricular cardiomyocytes causes an acute and transient increase in Ca2+ spark rate. (2009)
  • Author(s): Iribe G, Ward CW, Camelliti P, Bollensdorff C, Mason F, Burton RA, Garny A, Morphew MK, Hoenger A, Lederer WJ, Kohl P.
  • Journal Title: Circ Res. 104(6) Pages: 787-795
  • Peer Reviewed
• [Presentation] Effects of bepridil on stretch-induced arrhythmia in isolated chick ventricles. (2009)
  • Author(s): Iribe G, Jin H, Naruse K.
  • Organizer: European Society of Cardiology Congress 2009
  • Place of Presentation: Barcelona, Spain.
  • Year and Date: 20090829-20090902
• [Presentation] Mechanical modulation of cardiac calcium handling. (2009)
  • Author(s): Iribe G.
  • Organizer: 36th International Congrss of Physiological Sciences
  • Place of Presentation: Kyoto, Japan.
  • Year and Date: 20090727-20090801
• [Presentation] Mechano-electric interaction via calcium handling. (2009)
  • Author(s): Iribe G.
  • Organizer: 36th International Congrss of Physiological Sciences Satellite symposium #8
  • Place of Presentation: Kyoto, Japan.
  • Year and Date: 20090727-20090801
• [Presentation] New Insight into Acute Stretch Effects on Cardiac Calcium Handling. (2008)
  • Author(s): Iribe G.
  • Organizer: European Society of Cardiology Congress 2008
  • Place of Presentation: Munich, Germany.
  • Year and Date: 20080830-20080903
• [Book] 第5章 心血管系細胞への機械刺激負荷技術、バイオテクノロジーシリーズ 細胞分離・操作技術の最前線 (2008)
  • Author(s): 片野坂友紀、入部玄太郎、山田章、成瀬恵治
  • Total Pages: 265-275
  • Publisher: (株)シーエムシー出版
• [Book] Chapter 5 "Non-Sarcolemmal Stretch-Activated Channels" in "Cardiac Mechano-Electric Coupling & Arrhythmias 2^<nd> edition"
  • Author(s): Iribe G, Kohl P.
  • Publisher: in press