2010 Fiscal Year Final Research Report
Coronary Circulation-Cardiac Mechanics Coupling
| Project/Area Number |
20300160
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Biomedical engineering/Biological material science
|
|---|
| Research Institution | Kawasaki Medical School |
|---|
Principal Investigator |
MOHRI Satoshi Kawasaki Medical School, 医学部, 教授 (00294413)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
NARUSE Keiji 岡山大学, 医歯(薬)学総合研究科, 教授 (40252233)
KATANOSAKA Yuki 岡山大学, 医歯(薬)学総合研究科, 助教 (60432639)
NAKAMURA Kazufumi 岡山大学, 医歯(薬)学総合研究科, 講師 (10335630)
MIYASAKA Takehiro 姫路獨協大学, 保健医療学部, 教授 (60308195)
IRIBE Genntarou 岡山大学, 医歯(薬)学総合研究科, 助教 (90284885)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
HASHIMOTO Ken 川崎医科大学, 医学部, 講師 (80341080)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Keywords | 収縮能 / 拡張能 / 冠循環 / 心肥大 / Caトランスポータ |
|---|
| Research Abstract |
In vertebrates, there are two kinds of myocardium, compacta and spongiosa, which are associated with blood supply systems i.e. coronary and sinusoidal circulation. We analyzed the ventricular end-diastolic pressure-volume relationships in rat and frog heart that include integrated expression of chamber geometry and passive material properties of myocardial wall. Frog spongy ventricles showed higher expandability than rat left ventricles composed of compact myocardium. To assess how left ventricular geometry is regulated in heart failure, we generated an animal model of inducible and cardiac specific over-expression of Na^+/Ca^<2+> exchanger (NCX1) which is up-regulated in failing cardiac myocyte. We found that NCX1 over-expressing mice developed concentric hypertrophy with relaxation abnormality.
|
Research Products
(24 results)
-
-
-
-
-
-
-
-
-
-
[Presentation] 単球の内皮下浸潤によって誘発される次の単球浸潤の促進2010
Author(s)
橋本謙,片岡則之,毛利聡,辻岡克彦,梶谷文彦
Organizer
第25回生体・生理工学シンポジウム,The 25th Symposium on Biological and Physiological Engineering(オーガナイズドセッション「生体機能計測の新展開」,論文集,pp.469-470)
Place of Presentation
岡山
Year and Date
20100923-20100925
-
-
-
-
-
-
[Presentation] Monocyte trans-endothelial migration induces PECAM-1 accumulation and VE-cadherin reduction at the surface of vascular endothelial cells.2010
Author(s)
Ken Hashimoto, Noriyuki Kataoka, Emi Nakamura, Kimiko Hagihara, Takeaki Okamoto, Hiroaki Kanouchi, Yohsuke Minatogawa, Satoshi Mohri, Katsuhiko Tsujioka, Fumihiko Kajiya
Organizer
6th World Congress on Biomechanics, Singapore Suntec Convention Centre(abstract p148)
Year and Date
2010-08-01
-
-
-
[Presentation] Monocyte invasion induces redistribution and subsequent accumulation of endothelial PECAM-1 during para-, but not trans-cellular migration.2009
Author(s)
Hashimoto K, Kataoka N, Nakamura E, Hagihara K, Okamoto T, Kanouchi H, Minatogawa Y, Mohri S, Tsujioka K, Kajiya F
Organizer
36th Congress of the International Union of Physiological Sciences (IUPS2009),第86回日本生理学会大会(J.Physiol.Sci.59 (Suppl.1), p324, 2009)
Place of Presentation
京都
Year and Date
20090727-20090801
-
[Presentation] 細胞間隙を通る単球の浸潤により誘発される内皮細胞PECAM-1の再配置及び浸潤後の持続的集積2009
Author(s)
橋本謙,片岡則之,中村恵美,萩原喜美子,毛利聡,辻岡克彦,梶谷文彦
Organizer
第48回日本生体医工学会大会(生体医工学 Vol.47,Suppl.1,p331,2009.)
Place of Presentation
東京,CD-ROM
Year and Date
20090423-20090425
-
-
-
-
