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2010 Fiscal Year Final Research Report

Neural Interface Therapy for Severe Heart Failure

Research Project

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Project/Area Number 20300177
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical systems
Research InstitutionKochi University

Principal Investigator

SATO Takayuki  Kochi University, 教育研究部・医療学系, 教授 (90205930)

Co-Investigator(Renkei-kenkyūsha) YAMASAKI Fumiyasu  高知大学, 教育研究部・医療学系, 講師 (10243841)
KAKINUMA Yoshihiko  高知大学, 教育研究部・医療学系, 准教授 (40233944)
ARIKAWA Mikihiko  高知大学, 教育研究部・医療学系, 助教 (20432817)
ZHENG Can  高知大学, 教育研究部・医療学系, 助教 (50443495)
HANDA Takemi  高知大学, 医学部附属病院, 医員 (00437716)
NOGUCHI Tatsuya  高知大学, 医学部附属病院, 医員 (50566495)
Project Period (FY) 2008 – 2010
Keywords循環器・高血圧 / トランスレーショナルリサーチ / 神経インターフェース
Research Abstract

We previously reported that electric vagal nerve stimulation markedly improved long-term survival after chronic heart failure (CHF) in rats through cardioprotective effects of acetylcholine, independent of the hear rate-slowing mechanism. However, such an approach is invasive and its safety is unknown in clinical settings. To develop a noninvasive neural interface therapy with a clinically available drug, we examined the chronic effect of oral donepezil, an acetylcholinesterase inhibitor against Alzheimer's disease, on cardiac remodeling and survival with a murine model of volume-overloaded CHF. Oral donepezil treatment improve Oral donepezil improves survival of CHF mice through prevention of pumping failure and cardiac remodeling.

  • Research Products

    (48 results)

All 2011 2010 2009 2008

All Journal Article (14 results) (of which Peer Reviewed: 14 results) Presentation (32 results) Book (2 results)

  • [Journal Article] Feasibility of ICG fluorescence-guided sentinel node biopsy in animal models using the HyperEye Medical System.2011

    • Author(s)
      Yamauchi K, Nagafuji H, Nakamura T, Sato T, Kohno N
    • Journal Title

      Ann Sur Oncol. in press

    • Peer Reviewed
  • [Journal Article] Effects of various doses of aspirin on platelet activity and endothelial function.2011

    • Author(s)
      Furuno T, Yamasaki F, Yokoyama T, Sato K, Sato T, Doi Y, Sugiura T.
    • Journal Title

      Heart Vessels. in press

    • Peer Reviewed
  • [Journal Article] The effect of donepezil treatment on cardiovascular mortality.2010

    • Author(s)
      Sato K, Urbano R, Yu C, Yamasaki F, Sato T, Jordan J, Robertson D, Diedrich A.
    • Journal Title

      Clin Pharmacol Ther. 88

      Pages: 335-338

    • Peer Reviewed
  • [Journal Article] Differential regulation of TNF receptors by vagal nerve stimulation protect heart against acute ischemic injury.2010

    • Author(s)
      Katare RG, Ando M, Kakinuma Y, Arikawa M, Yamasaki F, Sato T.
    • Journal Title

      J Mol Cell Cardiol. 49

      Pages: 234-244

    • Peer Reviewed
  • [Journal Article] Donepezil, an acetylcholinesterase inhibitor against Alzheimer's dementia, promotes angiogenesis in an ischemic hindlimb model.2010

    • Author(s)
      Kakinuma Y, Furihata M, Akiyama T, Arikawa M, Handa T, Katare RG, Sato T.
    • Journal Title

      J Mol Cell Cardiol. 48

      Pages: 680-693

    • Peer Reviewed
  • [Journal Article] Engineered heart tissue : A novel tool to study the ischemic changes of the heart In vitro.2010

    • Author(s)
      Katare RG, Ando M, Kakinuma Y, Sato T.
    • Journal Title

      PLoS ONE 5

      Pages: e9275

    • Peer Reviewed
  • [Journal Article] A new device for the intraoperative graft assessment : The HyperEye charge-coupled device camera system.2010

    • Author(s)
      Handa T, Katare RG, Nishimori H, Wariishi S, Fukutomi T, Yamamoto M, Sasaguri S, Sato T.
    • Journal Title

      Gen Thorac Cardiovasc Surg. 58

      Pages: 68-77

    • Peer Reviewed
  • [Journal Article] Cholinoceptive and cholinergic properties of cardiomyocytes involving an amplification mechanism for vagal efferent effects in sparsely innervated ventricular myocardium.2009

    • Author(s)
      Kakinuma Y, Akiyama T, Sato T.
    • Journal Title

      FEBS J. 276

      Pages: 5111-5125

    • Peer Reviewed
  • [Journal Article] Anti-Alzheimer's drug, donepezil, markedly improves long-term survival after chronic heart failure in mice.2009

    • Author(s)
      Handa T, Katare RG, Kakinuma Y, Arikawa M, Ando M, Sasaguri S, Yamasaki F, Sato T.
    • Journal Title

      J Card Fail. 15

      Pages: 805-811

    • Peer Reviewed
  • [Journal Article] Preliminary experience for the evaluation of the intraoperative graft patency with real color charge-coupled device camera system : an advanced device for simultaneous capturing of color and near-infrared images during coronary artery bypass graft.2009

    • Author(s)
      Handa T, Sasaguri S, Sato T.
    • Journal Title

      Interact Cardiovasc Thorac Surg. 9

      Pages: 150-154

    • Peer Reviewed
  • [Journal Article] Faster and stronger vascular "Biotube" graft fabrication in vivo using a novel nicotine-containing mold.2009

    • Author(s)
      Sakai O, Kanda K, Takamizawa K, Sato T, Yaku H, Nakayama Y.
    • Journal Title

      J Biomed Mater Res B Appl Biomater. 90

      Pages: 412-420

    • Peer Reviewed
  • [Journal Article] Chronic intermittent fasting improves the survival following large myocardial ischemia by activation of BDNF/VEGF/PI3K signaling pathway.2009

    • Author(s)
      Katare RG, Kakinuma Y, Arikawa M, Yamasaki F, Sato T.
    • Journal Title

      J Mol Cell Cardiol. 46

      Pages: 405-412

    • Peer Reviewed
  • [Journal Article] Vagal nerve stimulation prevents reperfusion injury through inhibition of opening of mitochondrial permeability transition pore independent of the bradycardiac effect.2009

    • Author(s)
      Katare RG, Ando M, Kakinuma Y, Arikawa M, Handa T, Yamasaki F, Sato T.
    • Journal Title

      J Thorac Cardiovasc Surg. 137

      Pages: 223-231

    • Peer Reviewed
  • [Journal Article] Biphasic elevation of bilirubin oxidation during myocardial ischemia reperfusion.2008

    • Author(s)
      Yamamoto M, Maeda H, Hirose N, Yamamoto M, Nakagawa A, Radhakrishnan G, Katare RG, Sato T, Yamaguchi T, Sasaguri S.
    • Journal Title

      Circ J. 72

      Pages: 1520-1527

    • Peer Reviewed
  • [Presentation] 冠動脈バイパス術におけるHEMS-ICG造影法を用いた新血流評価法2011

    • Author(s)
      山本正樹
    • Organizer
      第41回日本心臓血管外科学会学術総会
    • Place of Presentation
      千葉県東京ベイ舞浜ホテルクラブリゾート
    • Year and Date
      2011-02-23
  • [Presentation] 日本医工ものつくりコモンズへの期待2010

    • Author(s)
      佐藤隆幸
    • Organizer
      第19回日本コンピュータ外科学会シンポジウム「日本のもの作りを医療へ生かす取り組み」
    • Place of Presentation
      福岡県九州大学医学部
    • Year and Date
      2010-11-03
  • [Presentation] Effects of a non-neuronal cholinergic system equipped for cardiomyocytes, as a molecular brake, on overshooting cardiac energy metabolism.2010

    • Author(s)
      柿沼由彦
    • Organizer
      19th International Conference of the Cardiovascular System Dynamics Society
    • Place of Presentation
      Fukuoka, Kyusyu University.
    • Year and Date
      2010-09-26
  • [Presentation] Donepezil, an acetylcholinesterase inhibitor, reduces the risk of left ventricular free wall rupture during an acute phase of myocardial infarction by attenuating macrophage matrix metalloproteinase-9.2010

    • Author(s)
      Arikawa M.
    • Organizer
      19th International Conference of the Cardiovascular System Dynamics Society
    • Place of Presentation
      Fukuoka, Kyusyu University.
    • Year and Date
      2010-09-26
  • [Presentation] Bionic baroreflex system for stabilizing arterial pressure by spinal cord stimulation and abdominal cuff.2010

    • Author(s)
      山本正樹
    • Organizer
      19th International Conference of the Cardiovascular System Dynamics Society
    • Place of Presentation
      Fukuoka, Kyusyu University
    • Year and Date
      2010-09-26
  • [Presentation] The new era of therapeutic modalities against heart failure, focusing on pharmacological intervention of the cardiovascular cholinergic system.2010

    • Author(s)
      柿沼由彦
    • Organizer
      19th International Conference of the Cardiovascular System Dynamics Society
    • Place of Presentation
      Fukuoka, Kyusyu University.
    • Year and Date
      2010-09-26
  • [Presentation] 塩酸ドネペジル内服による心血管系への影響に関する前向き登録調査研究2010

    • Author(s)
      久保亨
    • Organizer
      第11回Neurocardiology Workshop
    • Place of Presentation
      東京都東京ステーションコンファレンス
    • Year and Date
      2010-07-31
  • [Presentation] Effects of a non-central and non-neuronal acetylcholine synthesis system equipped for cardiomyocytes, as a molecular brake, on overshooting cardiac energy metabolism.2010

    • Author(s)
      柿沼由彦
    • Organizer
      第31回日本循環制御医学会総会
    • Place of Presentation
      大阪府千里ライフサイエンスセンター
    • Year and Date
      2010-05-29
  • [Presentation] A new intelligent technique of fluid restriction in small animals.2010

    • Author(s)
      鄭燦
    • Organizer
      第31回日本循環制御医学会総会
    • Place of Presentation
      大阪府千里ライフサイエンスセンター
    • Year and Date
      2010-05-28
  • [Presentation] Preliminary experiences of sentinel lymph node biopsy for early breast cancer by a new camera system simultaneously capturing color and near-infrared fluorescence.2010

    • Author(s)
      杉本健樹
    • Organizer
      7th European Breast Cancer Conference
    • Place of Presentation
      Barcelona, Spain.
    • Year and Date
      2010-03-25
  • [Presentation] Hyper Eye medical systemを用いた術中血流評価2010

    • Author(s)
      竹島智隆
    • Organizer
      第1回高知県臨床工学技士会学術セミナー
    • Place of Presentation
      高知市サンピアセリーズ
    • Year and Date
      2010-03-21
  • [Presentation] Effects of a non-neuronal acetylcholine synthesis system equipped for cardiomyocytes, as a molecular brake, on overshooting cardiac energy metabolism.2010

    • Author(s)
      柿沼由彦
    • Organizer
      第74回日本循環器学会総会・学術集会
    • Place of Presentation
      京都市国立京都国際会館
    • Year and Date
      2010-03-06
  • [Presentation] Donepezil : An acetylcholinesterase inhibitor against Alzheimer's dementia, prevents remodeling and improves survival in volume overload heart failure mice.2009

    • Author(s)
      半田武巳
    • Organizer
      American College of Cardiology 58th Annual Scientific Session
    • Place of Presentation
      Orlando USA.
    • Year and Date
      20090328-20090331
  • [Presentation] カラー視野とICG蛍光を同時に描出できる高感度CCDカメラの腹部外科へカメラの腹部外科への応用の可能性2009

    • Author(s)
      吉田昌
    • Organizer
      第11回Sentinel Node Navigation Surgery研究会学術集会
    • Place of Presentation
      東京都京王プラザホテル
    • Year and Date
      2009-11-28
  • [Presentation] ICG蛍光とカラー画像によるセンチネルリンパ節同定2009

    • Author(s)
      杉本健樹
    • Organizer
      第11回Sentinel Node Navigation Surgery研究会学術集会
    • Place of Presentation
      東京都京王プラザホテル
    • Year and Date
      2009-11-28
  • [Presentation] HyperEye Medical Systemの開発~非分光日時分割で近赤外蛍光と可視光カラーの同時取得~2009

    • Author(s)
      佐藤隆幸
    • Organizer
      第18回日本コンピュータ外科学会
    • Place of Presentation
      東京都東京大学
    • Year and Date
      2009-11-23
  • [Presentation] フルカラーにICG蛍光を描出できる新カメラシステムによる乳癌センチネルリンパ節生検2009

    • Author(s)
      杉本健樹
    • Organizer
      第71回日本臨床外科学会総会
    • Place of Presentation
      京都府国立京都国際会館
    • Year and Date
      2009-11-19
  • [Presentation] Donepezil markedly suppresses ventricular dysfunction and improves neurohumoral states on top of losartan in rats with extensive myocardial infarction.2009

    • Author(s)
      李梅花
    • Organizer
      American Heart Association Scientific sessions 2009
    • Place of Presentation
      Orlando, USA.
    • Year and Date
      2009-11-18
  • [Presentation] カラーインドシアニングリーン蛍光血管撮影装置を用いた術中グラフト評価2009

    • Author(s)
      武島智隆
    • Organizer
      第35回日本体外循環技術医学会大会
    • Place of Presentation
      大阪府大阪国際交流センター
    • Year and Date
      2009-10-10
  • [Presentation] Color ICG Angiography systemを用いた術中グラフト評価2009

    • Author(s)
      武島智隆
    • Organizer
      第19回日本臨床工学会
    • Place of Presentation
      徳島県アスティ徳島
    • Year and Date
      2009-05-09
  • [Presentation] Preliminary experience for the assessment of the intraoperative competitive flows with real color CCD camera system.2009

    • Author(s)
      半田武巳
    • Organizer
      58th ESCVS Annual Congress
    • Place of Presentation
      Warsaw, Poland.
    • Year and Date
      2009-05-01
  • [Presentation] Real color CCD Camera system ; New device for intraoperative graft assessment in CABG.2009

    • Author(s)
      半田武巳
    • Organizer
      58th ESCVS Annual Congress
    • Place of Presentation
      Warsaw, Poland.
    • Year and Date
      2009-05-01
  • [Presentation] Real Color CCD camera systemを使用したグラフト血流競合の術中評価2009

    • Author(s)
      半田武巳
    • Organizer
      第109回日本外科学会定期学術集会
    • Place of Presentation
      福岡県福岡国際会議場
    • Year and Date
      2009-04-03
  • [Presentation] Visual assessment for competitive graft flow using Real Color CCD camera system.2009

    • Author(s)
      半田武巳
    • Organizer
      第73回日本循環器学会総会・学術集会
    • Place of Presentation
      大阪府,大阪国際会議場
    • Year and Date
      2009-03-22
  • [Presentation] Donepezil, an acetylcholinesterase inhibitor against Alzheimer's dementia, prevents remodeling in volume-overload heart failure mice : Local and central effect of donepezil.2009

    • Author(s)
      半田武巳
    • Organizer
      第73回日本循環器学会総会・学術集会
    • Place of Presentation
      大阪府,大阪国際会議場
    • Year and Date
      2009-03-21
  • [Presentation] Anatomical study of breast lymphatics through sentinel lymphnode biopsy using a camera to capture color and near-infrared fluoroescence of indocyanine green.2008

    • Author(s)
      杉本健樹
    • Organizer
      The 26th Congress of the International Association for Breast Cancer Research.
    • Place of Presentation
      Kurashiki, Japan.
    • Year and Date
      20080922-20080924
  • [Presentation] New ultrahigh sensitive CCD camera for capturing of color and nearinfrared images during ICG angiography in CABG.2008

    • Author(s)
      半田武巳
    • Organizer
      18th World Society of Cardio-Thorasic Surgeons
    • Place of Presentation
      Kos Island, Greece.
    • Year and Date
      20080430-20080503
  • [Presentation] Cardiomyocytes produces acethylcholine in response to muscarinic receptor stimulation : A possible mechanism for amplification of cardioprotective effects of cardiac vagal nerve.2008

    • Author(s)
      柿沼由彦
    • Organizer
      American Heart Association Scientific sessions 2008
    • Place of Presentation
      New Orleans USA.
    • Year and Date
      2008-11-12
  • [Presentation] HIF-1alphaにより制御される新規因子は,ミトコンドリア転写因子を介してその機能を抑制し,細胞を低酸素から保護する2008

    • Author(s)
      柿沼由彦
    • Organizer
      第9回Neurocardiology Workshop
    • Place of Presentation
      東京都 東京ステーションコンファレンス
    • Year and Date
      2008-07-26
  • [Presentation] アセチルコリンエステラーゼ阻害薬とアンジオテンシンII受容体拮抗薬の併用投与による心筋梗塞後重症心不全ラットの心機能.心臓リモデリングの改善作用2008

    • Author(s)
      李梅花
    • Organizer
      第9回Neurocardiology Workshop
    • Place of Presentation
      東京都東京ステーションコンファレンス
    • Year and Date
      2008-07-26
  • [Presentation] 当教室で作成したカラーICG蛍光血管撮影装置(CIFI)の有効性-基礎から臨床へ2008

    • Author(s)
      半田武巳
    • Organizer
      第108回日本外科学会定期学術集会
    • Place of Presentation
      長崎県長崎ブリックホール
    • Year and Date
      2008-05-17
  • [Presentation] Sentinel lymph node biopsy for breast cancer using a new camera system for simultaneous capturing color and near-infrared fluorescence of indocyanine green.2008

    • Author(s)
      杉本健樹
    • Organizer
      EUROPEAN BREAST CANCER CONFERENCE
    • Place of Presentation
      Berlin, Germany.
    • Year and Date
      2008-04-17
  • [Book] アルツハイマー病に用いられるドネペジルの抗心不全作用2010

    • Author(s)
      佐藤隆幸
    • Total Pages
      496-498
    • Publisher
      科学評論社循環器内科
  • [Book] 脊髄電気刺激療法(XV.血圧コントロールシステムとしての脊髄電気刺激療法)(森本昌宏編著)2008

    • Author(s)
      牛田享宏, 山崎文靖, 横山武志, 佐藤隆幸
    • Total Pages
      213-220
    • Publisher
      克誠堂

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Published: 2012-01-26   Modified: 2016-04-21  

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