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2010 Fiscal Year Final Research Report

Activation of endogenous Schwann cells to promote remyelination in injured spinal cord

Research Project

  • PDF
Project/Area Number 20300190
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Rehabilitation science/Welfare engineering
Research InstitutionResearch Institute, National Rehabilitation Center for Persons with Disabilities

Principal Investigator

OGATA Toru  Research Institute, National Rehabilitation Center for Persons with Disabilities, 運動機能系障害研究部, 部長 (00392192)

Project Period (FY) 2008 – 2010
Keywordsシュワン細胞 / 髄鞘形成 / 細胞内シグナル
Research Abstract

To promote remyelination in injured spinal cord, we focused on Schwann cell and its functional modulation. The hypothesis that Schwann cell migration from dorsal roots is enhanced by exercises was not confirmed by rat spinal cord injury model. To develop other methods for functional modulation, we identified the function of Hes gene in downstream of growth factors, and also established in vivo evaluation model for functional modulation. These findings are supposed to contribute for developing therapeutic approaches using Schwann cells.

  • Research Products

    (7 results)

All 2011 2010 2009 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (5 results) Remarks (1 results)

  • [Journal Article] Hesl functions downstream of growth factors to maintain oligodendrocyte linage cells in the early progenitor stage2011

    • Author(s)
      Ogata T, Ueno T, Hoshikawa S, Ito J, Okazaki R, Hayakawa K, Morioka K, Yamamoto S, Nakamura K, Tanaka S, Akai M
    • Journal Title

      Neuroscience 176

      Pages: 132-41

    • Peer Reviewed
  • [Presentation] Molecular and Electrophysiological approaches for functional recovery in patients with injured spinal cord2010

    • Author(s)
      緒方徹
    • Organizer
      2nd International Symposium on Rehabilitation Research
    • Place of Presentation
      ソウル(韓国)
    • Year and Date
      2010-09-09
  • [Presentation] Molecular Link between bFGF signals and bHLH transcription factors in regulating proliferation and maturation of oligodendrocyte progenitor cells2009

    • Author(s)
      Toru Ogata, Takaaki Ueno, Kozo Nakamura, Masami Akai
    • Organizer
      第39回北米神経科学学会
    • Place of Presentation
      ワシントンDC(米国)
    • Year and Date
      2009-11-15
  • [Presentation] 脊髄損傷におけるグリア前駆細胞の活性化と組織修復2009

    • Author(s)
      緒方徹、伊藤順一、上野高明、星川慎弥、中村耕三、赤居正美
    • Organizer
      第24回日整会基礎学会
    • Place of Presentation
      横浜
    • Year and Date
      2009-11-05
  • [Presentation] 抗アポトーシス遺伝子導入シュワン細胞のラット脊髄損傷モデルへの移植およびその新しい組織学的評価法の確立2009

    • Author(s)
      星川慎弥、伊藤順一、上野高明、田中栄、中村耕三、緒方徹
    • Organizer
      第24回日整会基礎学会
    • Place of Presentation
      横浜
    • Year and Date
      2009-11-05
  • [Presentation] 脊髄損傷治療におけるHesファミリー分子の役割2009

    • Author(s)
      緒方徹、上野高明、伊藤順一、中村耕三、田中栄、赤居正美
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-16
  • [Remarks] ホームページ等

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Published: 2012-01-26   Modified: 2016-04-21  

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