2010 Fiscal Year Final Research Report
Does the habitual physical activity prevent arteriosclerosis related with MTHFR gene variation?
| Project/Area Number |
20300231
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | National Institute of Health and Nutrition |
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Principal Investigator |
MIYACHI Motohiko National Institute of Health and Nutrition, 運動ガイドラインプロジェクト, リーダー (60229870)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 習慣的身体活動 / ホモシステイン / 動脈硬化 / 遺伝子多型 / MTHFR |
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| Research Abstract |
The purpose of the cross-sectional study was to examine the associations among MTHFR 677C→T polymorphism, plasma homocysteine (Hcy) concentration, arterial stiffness, and lifestyle (eating habit, fitness, and physical activity).
(1) Arterial stiffness and plasma homocysteine in participants with MTHFR677TT genotype were significantly higher than those with CC and TT genotypes.
(2) However, there were significant interactions between time spent in light PA (p=0.003), vigorous PA (p=0.001), or inactivity (p=0.004) and MTHFR genotype. In only the TT genotype, shorter time spent in light PA was associated with higher plasma Hcy than a longer time spent in light PA (11.5±3.3nmol/mL vs.8.5±3.3nmol/mL, p<0.001), and longer time spent in vigorous PA and inactivity were associated with higher plasma Hcy (11.8±3.3nmol/mL vs 8.4±3.2nmol/mL, 11.6±3.3nmol/mL vs.8.4±3.3nmol/mL, respectively, p<0.001).
(3) Plasma Hcy was significantly different between ≧200 (7.6±0.2nmol/mL) and <200μg/day (8.3±0.3nmol/mL) folate intake groups (p=0.003).
(4) The plasma homocysteine level was higher in the TT genotype of MTHFR C677T polymorphism compared with CC and CT genotype individuals. MTHFR C677T polymorphism showed no effect on carotid beta-stiffness, but there was a significant interaction effect between fitness and MTHFR C677T polymorphism on carotid beta-stiffness (P=0.0017). In the Low-Fit subjects, carotid beta-stiffness was significantly higher in individuals with the TT genotype than the CC and CT genotypes. However, there were no such differences in High-Fit subjects.
These results imply that CVD risk factors are affected by both genetic and environmental factors. However, further investigations using the larger sample size or longitudinal design will be needed to confirm these findings.
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[Journal Article] Associations among objectively measured physical activity, fasting plasma homocysteine concentration, and MTHFR C677T genotype.2011
Author(s)
Murakami H, Iemitsu M, Sanada K, Gando Y, Ohmori Y, Kawakami R, Sasaki S, Tabata I, Miyachi M.
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Journal Title
Eur J Appl Physiol. [Epub ahead of print] PubMed PMID : 21451940.
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