2010 Fiscal Year Final Research Report
Studies on the effects of prenatal exposure to bisphenol A in mouse brain, with special reference to neuronal migration and epigenetic alteratio ns
| Project/Area Number |
20310036
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
FUSHIKI Shinji 京都府立医科大学, 医学研究科, 教授 (80150572)
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| Co-Investigator(Kenkyū-buntansha) |
ITOH Kyoko 京都府立医科大学, 医学研究科, 准教授 (80243301)
YAOI Takeshi 京都府立医科大学, 医学研究科, 助教 (40311914)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 内分泌かく乱物質 / ビスフェノールA / マウス / 神経細胞移動 / エピジェネティックス |
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| Research Abstract |
We demonstrated that prenatal and lactational exposure to bisphenol A(BPA) affected fetal brain development, resulting in disturbed murine behavior accompanied with disrupted neurotransmitter system, including monoamines, in the postnatal development period and in adult mice. We also demonstrated that epigenetic alterations in promoter-associated CpG islands might underlie some of the effects on brain development after exposure to BPA.
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