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2010 Fiscal Year Self-evaluation Report

Study of cell polarity control in yeast

Research Project

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Project/Area Number 20380063
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied biochemistry
Research InstitutionHiroshima University

Principal Investigator

HIRATA Dai  Hiroshima University, 大学院・先端物質科学研究科, 教授 (30243603)

Project Period (FY) 2008 – 2011
Keywords情報伝達 / 細胞極性 / 細胞周期 / チェックポイント
Research Abstract

すべての真核細胞は、固有の細胞形態を有し、それは細胞の機能と密接に関係している。細胞形態を決定する重要な因子が細胞極性である。一方、チェックポイント機構は、生命維持にとって重大な異常が生じた際、その異常を解消するまで自身の細胞増殖を停止させる、生命維持にとって必須な機構である。近年、チェックポイント機構の異常が細胞癌化の一要因であることが示され、本機構の理解が、細胞癌化を解明するための中心課題になっている。そこで、本研究では、ヒトのモデル細胞である酵母をつかって、細胞極性と細胞周期との連携制御機構について解析し、その知見を、医薬探索系開発のための基盤研究へと展開する。

  • Research Products

    (11 results)

All 2011 2010 2009 2008 Other

All Journal Article (5 results) Presentation (5 results) Remarks (1 results)

  • [Journal Article] Calcineurin ensures a linkage between DNA replication checkpoint and microtubule-dependent polarized growth.2011

    • Author(s)
      Kazunori Kume, Takayuki Koyano, Muneyoshi Kanai, Takashi Toda, Dai Hirata
    • Journal Title

      Nature Cell Biology 13(3)

      Pages: 234-242

  • [Journal Article] Fission yeast Germinal Center (GC) kinase Ppk11 interacts with Pmo25 and plays an auxiliary role in concert with the morphogenesis Orb6 network (MOR) in cell morphogenesis.2010

    • Author(s)
      Testuya Goshima, Kazunori Kume, Takayuki Koyano, Yoshikazu Ohya, Takashi Toda, Dai Hirata
    • Journal Title

      J.Biol.Chem 285(45)

      Pages: 35196-35205

  • [Journal Article] The mitosis-to-interphase transition is coordinated by crosstalk between the SIN and MOR pathways in Shizosaccharomyces pombe.2010

    • Author(s)
      Samriddha Ray, Kazunori Kume, Sneha Gupta, Wanzhong Ge, Mohan Balasubramanian, Dai Hirata, Dannel McCollum
    • Journal Title

      J.Cell Biol 190(5)

      Pages: 793-805

  • [Journal Article] Search for kinases related to transition of growth polarity in fission yeast.2010

    • Author(s)
      Takayuki Koyano, Kazunori Kume, Manabu Konishi, Takashi Toda, Dai Hirata
    • Journal Title

      Biosci.Biotechnol.Biochem 74(5)

      Pages: 1129-1133

  • [Journal Article] Identification of Tupl and Cyc8 mutations defective in the responses to osmotic stress.2008

    • Author(s)
      Yoshifumi Kobayashi, Tomomi Inai, Masaki Mizunuma, Ichitaro Okada, Atsunori Shitamukai, Dai Hirata, Tokichi Miyakawa
    • Journal Title

      Biochemical and Biophysical Research Communications 368(1)

      Pages: 50-55

  • [Presentation] The signaling pathway linking DNA replication to cell polarization2011

    • Author(s)
      Kazunori Kume, Dai Hirata
    • Organizer
      The 6th UK-Japan Cell Cycle Workshop
    • Place of Presentation
      Windermere UK.
    • Year and Date
      20110410-20110414
  • [Presentation] The Ca2+-signaling pathways is involved in the replicative lifespan in budding yeast2010

    • Author(s)
      Ryohei Tsubakiyama, Masaki Mizunuma, Kazunori Kume, Tokichi Miyakawa, Dai Hirata
    • Organizer
      2010 CSHL Meeting on Molecular Genetics of Aging
    • Place of Presentation
      New York USA.
    • Year and Date
      20100928-20101002
  • [Presentation] Search for kinases related to the transition of growth polarity in fission yeast2010

    • Author(s)
      Takayuki Koyano, Kazunori Kume, Dai Hirata
    • Organizer
      The 2010 Yeast Genetics and Moleculra Biology Meeting
    • Place of Presentation
      Vancouver Canada
    • Year and Date
      20100727-20100801
  • [Presentation] Analysis of yeast lifespan mediated by the Ca2+-signaling pathways2009

    • Author(s)
      Ryohei Tsubakiyama, Masaki Mizunuma, Kazunori Kume, Tokichi Miyakawa, Dai Hirata
    • Organizer
      49th Annual Meeting of the American Society for Cell Biology
    • Place of Presentation
      California (San Diego) USA
    • Year and Date
      20091205-20091209
  • [Presentation] Growth polarity control through regulation of microtubule plus-end tracking proteins by checkpoint kinase2009

    • Author(s)
      Dai Hirata
    • Organizer
      The 5th International Fission Yeast Meeting
    • Place of Presentation
      Tokyo Japan
    • Year and Date
      20091026-20091031
  • [Remarks] 久米一規、五島徹也、平田大、分裂酵母の2つのHippo関連経路のクロストーク、実験医学、Vol.29,445-448(2011)

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Published: 2012-02-13   Modified: 2016-04-21  

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