2011 Fiscal Year Final Research Report
Basic and applied research on cell polarity control yeast
| Project/Area Number |
20380063
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied biochemistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
HIRATA Dai 広島大学, 大学院・先端物質科学研究科, 教授 (30243603)
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| Co-Investigator(Renkei-kenkyūsha) |
MIZUNUMA Masaki 広島大学, 大学院・先端物質科学研究科, 准教授 (10343295)
KUME Kazunori 広島大学, 大学院・先端物質科学研究科, 助教 (80452613)
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| Project Period (FY) |
2008 – 2011
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| Keywords | 情報伝達 / 細胞極性 / チェックポイント |
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| Research Abstract |
In this study, we analyzed the coordinated regulation between cell polarity and the cellcycle in yeast. We have identified a novel molecule in the MOR(Morphogenesis Orb6 Network) pathway that is important for establishment/ maintenance of cell polarity in fission yeast, and showed that the mitosis-to-interphase transition is coordinated by crosstalk between the SIN(Septation Initiation Network) and MOR pathways. Further, we found a new CCT(Cds1-Calcineurin-TIPs) pathway, in which calcineurin ensures a link between the DNA replication checkpoint and microtubule-dependent polarized growth in fission yeast. As all the molecules in the CCT pathway are conserved ubiquitously, it is hoped that the similar mechanism is operational in human beings and new cancer therapeutics would be developed based upon this finding.
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