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2011 Fiscal Year Final Research Report

Basic and applied research on cell polarity control yeast

Research Project

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Project/Area Number 20380063
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied biochemistry
Research InstitutionHiroshima University

Principal Investigator

HIRATA Dai  広島大学, 大学院・先端物質科学研究科, 教授 (30243603)

Co-Investigator(Renkei-kenkyūsha) MIZUNUMA Masaki  広島大学, 大学院・先端物質科学研究科, 准教授 (10343295)
KUME Kazunori  広島大学, 大学院・先端物質科学研究科, 助教 (80452613)
Project Period (FY) 2008 – 2011
Keywords情報伝達 / 細胞極性 / チェックポイント
Research Abstract

In this study, we analyzed the coordinated regulation between cell polarity and the cellcycle in yeast. We have identified a novel molecule in the MOR(Morphogenesis Orb6 Network) pathway that is important for establishment/ maintenance of cell polarity in fission yeast, and showed that the mitosis-to-interphase transition is coordinated by crosstalk between the SIN(Septation Initiation Network) and MOR pathways. Further, we found a new CCT(Cds1-Calcineurin-TIPs) pathway, in which calcineurin ensures a link between the DNA replication checkpoint and microtubule-dependent polarized growth in fission yeast. As all the molecules in the CCT pathway are conserved ubiquitously, it is hoped that the similar mechanism is operational in human beings and new cancer therapeutics would be developed based upon this finding.

  • Research Products

    (15 results)

All 2012 2011 2010 2009 2008 Other

All Journal Article (10 results) (of which Peer Reviewed: 9 results) Presentation (3 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Calcineurin ensures a link between DNA replication checkpoint and microtubule-dependent polarized growth2011

    • Author(s)
      Kume Kazunori, Koyano Takayuki, Kanai Muneyoshi, Toda Takashi, andHirata Dai
    • Journal Title

      Nature Cell Biology

      Volume: 13 Pages: 234-242

    • Peer Reviewed
  • [Journal Article] Systematic localization study on novel proteins encoded by meiotically up-regulated ORFs in fission yeast2011

    • Author(s)
      Ikebe Chio, Konishi Manabu, Hirata Dai, Matsuoka Takahiro, and Toda Takashi
    • Journal Title

      Biosci. Biotechnol. Biochem

      Volume: 75 Pages: 2364-2370

    • Peer Reviewed
  • [Journal Article] Implication of Ca2+ in the regulation of replicative life span of budding yeast2011

    • Author(s)
      Tsubakiyama Ryohei, Mizunuma Masaki, Gengyo Anri, Yamamoto Josuke, Kume Kazunori, Miyakawa Tokichi, and Hirata Dai
    • Journal Title

      J. Biol. Chem

      Volume: 286 Pages: 28681-28687

    • Peer Reviewed
  • [Journal Article] 出芽酵母の寿命研究の現状と展望2011

    • Author(s)
      水沼正樹, 平田大
    • Journal Title

      日本醸造協会誌(日本醸造学会)

      Volume: 30 Pages: 794-800

    • Peer Reviewed
  • [Journal Article] DNA複製と細胞極性をつなぐ経路癌細胞の異常な形を理解するヒント2011

    • Author(s)
      久米一規, 平田大
    • Journal Title

      細胞工学(秀潤社)

      Volume: 29 Pages: 854-855

    • Peer Reviewed
  • [Journal Article] 分裂酵母の2つのHippo関連経路のクロストーク2011

    • Author(s)
      久米一規, 五島徹也, 平田大
    • Journal Title

      実験医学(羊土社)

      Volume: 29 Pages: 445-448

  • [Journal Article] Fission yeast Germinal Center(GC) kinase Ppk11 interacts with Pmo25 and plays an auxiliary role in concert with the morphogenesis Orb6 network(MOR) in cell morphogenesis2010

    • Author(s)
      Goshima Tetsuya, Kume Kazunori, Koyano, Takayuki, Ohya Yoshikazu, Toda Takashi, and Hirata Dai
    • Journal Title

      J. Biol. Chem

      Volume: 285 Pages: 35196-35205

    • Peer Reviewed
  • [Journal Article] The mitosis-to-interphase transition is coordinated by crosstalk between the SIN and MOR pathways in Shizosaccharo myces pombe2010

    • Author(s)
      Ray Samriddha, Kume Kazunori, Gupta Sneha, Ge Wanzhong, Balasubramanian Mohan, Hirata Dai, and McCollum Dannel
    • Journal Title

      J. Cell Biol

      Volume: 190 Pages: 793-805

    • Peer Reviewed
  • [Journal Article] Search for kinases related to transition of growth polarity in fission yeast2010

    • Author(s)
      Koyano Takayuki, Kume Kazunori, Konishi Manabu, Toda Takashi, and Hirata Dai
    • Journal Title

      Biosci. Biotechnol. Biochem

      Volume: 74 Pages: 1129-1133

    • Peer Reviewed
  • [Journal Article] Identification of Tup1 and Cyc8 mutationsdefectivein the responses to osmotic stress2008

    • Author(s)
      Kobayashi Yoshifumi, Inai Tomomi, Mizunuma Masaki, Okada Ichitaro, Shitamukai Atsunori, Hirata Dai, and Miyakawa Tokichi
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 368 Pages: 50-55

    • Peer Reviewed
  • [Presentation] The signaling pathway linking DNA replication to cell polarization2011

    • Author(s)
      Kume Kazunori, and Hirata Dai
    • Organizer
      The 6th International Fission Yeast Meeting
    • Place of Presentation
      Boston U. S. A.
    • Year and Date
      20110625-30
  • [Presentation] The signaling pathway linking DNA replication to cell polarization2011

    • Author(s)
      Kume Kazunori, and Hirata Dai
    • Organizer
      The 6th UK-Japan Cell Cycle Workshop
    • Place of Presentation
      Ambleside UK
    • Year and Date
      20110410-14
  • [Presentation] otubule plus-end tracking proteins by checkpoint kinase2009

    • Author(s)
      Kume Kazunori, and Hirata Dai
    • Organizer
      The 5th International Fission Yeast Meeting
    • Place of Presentation
      Tokyo Japan
    • Year and Date
      20091026-31
  • [Remarks]

    • URL

      http://www.hiroshima-u.ac.jp/adsm/bio/s

  • [Patent(Industrial Property Rights)] カルシニューリン活性を抑制する物質のスクリーニング方法2012

    • Inventor(s)
      平田大、水沼正樹、久米一規
    • Industrial Property Rights Holder
      広島大学
    • Industrial Property Number
      特許、特願2012-046380
    • Filing Date
      2012-03-02

URL: 

Published: 2013-07-31  

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