2010 Fiscal Year Final Research Report
Studies on mechanisms of action of sterol metabolism regulating proteins and their regulation by functional food components
| Project/Area Number |
20380073
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Tohoku University |
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Principal Investigator |
IKEDA Ikuo Tohoku University, 大学院・農学研究科, 教授 (40136544)
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| Project Period (FY) |
2008 – 2010
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| Keywords | ABCG5 / ABCG8 / 植物ステロール / コレステロール / ラット / 吸収 / 胆汁 |
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| Research Abstract |
We compared lymphatic absorption and biliary excretion of plant sterols in normal rats and rats having a mutation in ATP-binding cassette transporter (ABC) G5 and depositing plant sterols in their body. Although the mutation rats deposited plant sterols in the body, any significant differences were not observed in both parameters. These observations suggest that the plant sterol excretion ability of ABCG5/ABCG8 in rats is poor and the deposition of plant sterols in the body of the mutation rats is caused by small reduction of plant sterol excretion. We showed that dietary sesamin increased expression of hepatic ABCG5 and ABCG8 mRNA in rats. Dietary sesamin increased biliary excretion of cholesterol in rats. It is thought that increased excretion of biliary cholesterol is caused by increased expression of ABCG5/ABCG8. Our results also suggest that increased expression of ABCG5/ABCG8 is caused by the reduction of insulin secretion by sesamin. However, energy metabolism was not influenced by dietary sesamin.
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