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2010 Fiscal Year Final Research Report

Analysis of the toxicological effects of phthalate esters on testes by administration, culture and transplantation methods

Research Project

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Project/Area Number 20380153
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied animal science
Research InstitutionThe University of Tokyo

Principal Investigator

KUROHMARU Masamichi  東京大学, 大学院・農学生命科学研究科, 教授 (00148636)

Co-Investigator(Kenkyū-buntansha) KANAI Yoshiakira  東京大学, 大学院・農学生命科学研究科, 准教授 (30260326)
OHSAKO Seiichiro  東京大学, 大学院・医学(系)研究科, 准教授 (00274837)
MAEDA Seishi  兵庫医科大学, 医学部, 准教授 (10309445)
TSUNEKAWA Naoki  東京大学, 大学院・農学生命科学研究科, 助教 (50431838)
Project Period (FY) 2008 – 2010
KeywordsDi(n-butyl) phthalate / Di-iso-butyl phthalate / 精細胞 / アポトーシス / テストステロン濃度 / ステロイドホルモン合成酵素 / エストロゲン / エストロゲンレセプター
Research Abstract

Phthalate esters, widely used as a plasticizer in the manufacturing process of consumer products, are known to affect testes toxicologically. In the present study, di(n-butyl) phthalate(DBP) and di-iso-butyl phthalate(DiBP) which belong to phthalate esters, are used as materials, and the mechanism of their toxicological effects on testes are investigated by some different methods. As a result, DBP acts like an estrogen, and induces spermatogenic cell apoptosis, probably by activating estrogen receptors. On the other hand, DiBP induces spermatogenic cell apoptosis, probably independent of estrogen-mediated activity.

  • Research Products

    (9 results)

All 2010 2009 2008 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (4 results)

  • [Journal Article] Induction of spermatogenic cell apoptosis in prepubertal rat testes irrespective of testicular steroidogenesis : A possible estrogenic effect of di(n-butyl) phthalate2010

    • Author(s)
      Alam, M. S., Ohsako, S., Matsuwaki, T., Zhu, X. B., Tsunekawa, N., Kanai, Y., Sone, H., Tohyama, C. and Kurohmaru, M.
    • Journal Title

      Reproduction

      Volume: Vol.139 Pages: 427-437

    • Peer Reviewed
  • [Journal Article] Di(n-butyl) phthalate induce vimentin filaments disruption in rat Sertoli cells : A possible relation with spermatogenic cell apoptosis2010

    • Author(s)
      Alam, M. S., Ohsako, S., Tay, T. W., Tsunekawa, N., Kanai, Y. and Kurohmaru, M.
    • Journal Title

      Anat. Histol. Embryol

      Volume: Vol.39 Pages: 186-193

    • Peer Reviewed
  • [Journal Article] A new preparation protocol for measurement of testicular sperm production2008

    • Author(s)
      Choi, E. K., Tsunekawa, N., Kanai, Y. and Kurohmaru, M.
    • Journal Title

      J. Reprod. Dev.

      Volume: Vol.54, No.1 Pages: 90-93

    • Peer Reviewed
  • [Journal Article] Single administration of di(n-butyl) phthalate delays spermatogenesis in prepubertal rats

    • Author(s)
      Alam, M. S., Andriana, B. B., Tay, T. W., Tsunekawa, N., Kanai, Y. and Kurohmaru, M.
    • Journal Title

      Tissue & Cell

      Volume: Vol.42, No.2 Pages: 129-135

    • Peer Reviewed
  • [Journal Article] Effects of di-iso-butyl phthalate on testes of prepubertal rats and mice

    • Author(s)
      Zhu, X. B., Tay, T. W., Andriana, B. B., Alam, M. S., Choi, E. K., Tsunekawa, N., Kanai, Y. and Kurohmaru, M.
    • Journal Title

      Okajimas Folia Anat. Jpn.

      Volume: Vol.86, No.4 Pages: 129-136

    • Peer Reviewed
  • [Presentation] Di(n-butyl) phthalate(DBP) induces spermatogenic cell apoptosis via estrogen receptor in prepubertal rat testes2009

    • Author(s)
      Mohammad Shah Alam,大迫誠一郎,祝暁波,恒川直樹,金井克晃,九郎丸正道
    • Organizer
      第147回日本獣医学会
    • Place of Presentation
      宇都宮
    • Year and Date
      20090000
  • [Presentation] Induction of spermatogeni cell apoptosis in prepubertal rat testes : an estrogeniceffect of di(n-butyl) phthalate and its relationship with testicular steroidogenesis2009

    • Author(s)
      Alam, M. S., Ohsako, S., Tsunekawa, N. K anai, Y., Tohyama, C., Kurohmaru, M.
    • Organizer
      The 3^<rd. Congress of the Asian Association of Veterinary Anatomists
    • Place of Presentation
      Korea
    • Year and Date
      20090000
  • [Presentation] Induction of spermatogenic cell apoptosis in prepubertal rat testes irrespective of testicular steroidogenesis : a possible estrogenic effect of di(n-butyl) phthalate2009

    • Author(s)
      Alam, M. S., Ohsako, S., Matsuwaki, T., Tsunekawa, N., Kanai, Y., Kurohmaru, M.
    • Organizer
      21^<st> Century Advances in the Molecular Toxicology of Environmental Chemicals and Pathogenesis of Disease
    • Place of Presentation
      Tokyo
    • Year and Date
      20090000
  • [Presentation] Di-iso-butyl phthalate(DIBP)の精巣毒性における特異性の検討2008

    • Author(s)
      祝暁波,大迫誠一郎, Mohammad Shah Alam,恒川直樹,金井克晃,遠山千春,九郎丸正道
    • Organizer
      第146回日本獣医学会
    • Place of Presentation
      宮崎
    • Year and Date
      20080000

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Published: 2013-07-31  

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