2010 Fiscal Year Final Research Report
Development of a novel therapy for canine atopic dermatitis with chimera IgG of anti-canine IgE antibody
| Project/Area Number |
20380172
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Clinical veterinary science
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| Research Institution | Gifu University |
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Principal Investigator |
MAEDA Sadatoshi Gifu University, 応用生物科学部, 教授 (50377694)
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| Co-Investigator(Kenkyū-buntansha) |
MIZUNO Takuya 山口大学, 農学部, 准教授 (90398826)
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| Research Collaborator |
TSOHIHIRO Tsukui 日本全薬工業株式会社, 主任研究員
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| Project Period (FY) |
2008 – 2010
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| Keywords | アトピー性皮膚炎 / 動物モデル / イヌ / IgE |
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| Research Abstract |
We tried to produce anti-canine IgE antibodies that could inhibit a binding of IgE to mast cells in order to develop a novel therapy for canine atopic dermatitis. Ten clones of the antibodies were generated by immunization of recombinant protein of the mast cell binding sites of IgE. The present results indicated that the antibodies could not inhibit a binding IgE to mast cells and also an allergen-mediated degranulation.
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