2010 Fiscal Year Final Research Report
Organic synthesis using cationic species under non-acidic conditions
| Project/Area Number |
20390004
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2008 – 2010
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| Keywords | 合成化学 |
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| Research Abstract |
Efficient deprotection of acetal-type protective groups(MOM-, MEM-, SEM-, and BOM-ether) of hydroxyl function and one-pot transformation of MOM-ethers to other acetal-type protective groups have been developed. Introduction of some nucleophiles to the anomeric position of 2-deoxysugars via cationic salt intermediates has been succeeded. Nucleophilic substitution of carbon nucleopohiles to cationic salt intermediate has been developed by studying the kind of pyridine-type base for forming salt. Efficient preparation method of crowded ethers, which are hard to be synthesized by previous methods, has been developed by the reaction of the salts, from MOM-ethers, and organocuprate reagents.
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