2010 Fiscal Year Final Research Report
Preparation of new chiral building blocks and their practical use in the enantioselective total synthesis of bioactive polycyclic natural products
| Project/Area Number |
20390006
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Waseda University |
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Principal Investigator |
NAKADA Masahisa Waseda University, 理工学術院, 教授 (50198131)
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| Co-Investigator(Kenkyū-buntansha) |
NOGUCHI Naoyoshi 早稲田大学, 理工学術院, 助手 (70454048)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 合成化学 / 全合成 |
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| Research Abstract |
Preparation of new chiral building blocks has advantage in the enantioselective total synthesis of naturally occurring important organic compounds (natural products) possessing diverse structures. In this research project, preparation methods of chiral building blocks via the catalysis with enzymes or chiral catalysts have been developed and they have been successfully applied to the enantioselective total synthesis of natural products including first syntheses. The chiral building blocks as well as their preparation methods will be used in the total synthesis of other natural products.
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