2010 Fiscal Year Final Research Report
A Comprehensive Study on the Drug-Drug Interactions in Drug Metabolizing Enzyme CYP
| Project/Area Number |
20390011
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Osaka University |
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Principal Investigator |
UNO Tadayuki Osaka University, 大学院・薬学研究科, 教授 (00183020)
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| Co-Investigator(Kenkyū-buntansha) |
AOYAMA Hiroshi 大阪大学, 大学院・薬学研究科, 准教授 (60291910)
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| Project Period (FY) |
2008 – 2010
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| Keywords | シトクロムP450 / 薬物代謝 / 一塩基多型 / 共鳴ラマン分光 / X線結晶構造解析 |
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| Research Abstract |
Cytochrome P450 (CYP) plays a key role in human drug metabolism, and drug-drug interactions in the substrate binding pocket of CYPs often induce unexpected adverse effects of drugs. In this study, drug binding and metabolizing properties of CYP were examined comprehensively, aiming at revealing a set of drugs susceptible to drug-drug interactions and effects of SNPs on the interactions. We could reveal that drug orientation in the substrate binding pocket can be detected spectroscopically, and that the active-site structure of CYPs is affected by the binding of two drugs simultaneously.
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