2010 Fiscal Year Final Research Report
Research on aging-related diseases and functional alterations of glycans during aging
| Project/Area Number |
20390031
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Tokyo Metropolitan Institute of Gerontology |
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Principal Investigator |
ENDO Tamao Tokyo Metropolitan Institute of Gerontology, 東京都健康長寿医療センター研究所, 研究部長 (30168827)
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| Co-Investigator(Renkei-kenkyūsha) |
YOKO Sakurai 地独東京都健康長寿医療センター, 東京都健康長寿医療センター研究所, シニアスタッフ (50344065)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 老化 / 糖鎖 / アルツハイマー |
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| Research Abstract |
We aimed to clarify the relation between aging-related diseases and the glycan functions by researching the aging-associated glycan alterations and its regulatory mechanisms. At first, we demonstrated that the oxidative stresses and the proteasome functions influenced the accumulation of the ectopic abnormal glycoproteins in the aging brain. Secondary, we observed that the adaptive responses to the oxidative stresses took part in a healthy long life by analyzing the oxidative stress-associated blood proteins in the long life senior citizen (centenarian). Finally, we found that the glycosyltransferase, GnT-III expression was increased in Alzheimer's brains and the secretion of β-amyloid peptides from neuronal cells was inhibited by GnT-III.
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